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    DA1 DA1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838510, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DA1
    Official Full Name
    DA1
    Primary source
    TAIR:AT1G19270
    Locus tag
    AT1G19270
    See related
    Araport:AT1G19270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DA (large in Chinese) 1; T29M8.14; T29M8_14
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    Genomic context

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    See DA1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (6662417..6666032)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene flavin-dependent monooxygenase 1 Neighboring gene TTF-type zinc finger protein with HAT dimerization domain-containing protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of final seed and organ size by the DA1 gene family in Arabidopsis thaliana. Li Y, et al. Genes Dev, 2008 May 15. PMID 18483219, Free PMC Article
    2. Modulation of receptor-like transmembrane kinase 1 nuclear localization by DA1 peptidases in Arabidopsis. Gu B, et al. Proc Natl Acad Sci U S A, 2022 Oct 4. PMID 36161927, Free PMC Article
    3. Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis. Dong H, et al. Genes Dev, 2017 Jan 15. PMID 28167503, Free PMC Article
    4. Forever Young: The Role of Ubiquitin Receptor DA1 and E3 Ligase BIG BROTHER in Controlling Leaf Growth and Development. Vanhaeren H, et al. Plant Physiol, 2017 Feb. PMID 28003326, Free PMC Article
    5. The ubiquitin receptor DA1 regulates seed and organ size by modulating the stability of the ubiquitin-specific protease UBP15/SOD2 in Arabidopsis. Du L, et al. Plant Cell, 2014 Feb. PMID 24585836, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The trxG protein ULT1 regulates Arabidopsis organ size by interacting with TCP14/15 to antagonize the LIM peptidase DA1 for H3K4me3 on target genes.
      Title: The trxG protein ULT1 regulates Arabidopsis organ size by interacting with TCP14/15 to antagonize the LIM peptidase DA1 for H3K4me3 on target genes.
    2. The integrated LIM-peptidase domain of the CSA1-CHS3/DAR4 paired immune receptor detects changes in DA1 peptidase inhibitors in Arabidopsis.
      Title: The integrated LIM-peptidase domain of the CSA1-CHS3/DAR4 paired immune receptor detects changes in DA1 peptidase inhibitors in Arabidopsis.
    3. Modulation of receptor-like transmembrane kinase 1 nuclear localization by DA1 peptidases in Arabidopsis.
      Title: Modulation of receptor-like transmembrane kinase 1 nuclear localization by DA1 peptidases in Arabidopsis.
    4. DA1 role in controlling leaf growth and senescence
      Title: Forever Young: The Role of Ubiquitin Receptor DA1 and E3 Ligase BIG BROTHER in Controlling Leaf Growth and Development.
    5. DA1 peptidase activity regulates the duration of cell proliferation and the transition to endoreduplication and differentiation during organ formation in plants by coordinating the destabilization of regulatory proteins.
      Title: Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis.
    6. DA1, DAR1, and DAR2 physically interact with the transcription factors TCP14 and TCP15, which repress endoreduplication.
      Title: The ubiquitin receptors DA1, DAR1, and DAR2 redundantly regulate endoreduplication by modulating the stability of TCP14/15 in Arabidopsis.
    7. Genetic analyses show that DA2 functions synergistically with DA1 to regulate seed size, but does so independently of EOD1. Further results reveal that DA2 interacts physically with DA1 in vitro and in vivo.
      Title: The ubiquitin receptor DA1 interacts with the E3 ubiquitin ligase DA2 to regulate seed and organ size in Arabidopsis.
    8. Genetic analyses indicate that UBP15 functions antagonistically in a common pathway with DA1 to influence seed size, but does so independently of DA2 and EOD1.
      Title: The ubiquitin receptor DA1 regulates seed and organ size by modulating the stability of the ubiquitin-specific protease UBP15/SOD2 in Arabidopsis.
    9. Overexpression of a da1-1 cDNA dramatically increases seed and organ size of wild-type plants.
      Title: Control of final seed and organ size by the DA1 gene family in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001332389.1
    NM_101785.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within multidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant ovule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA endoreduplication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of seed growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DA1
    NP_173361.1
    • DA1 (DA1); CONTAINS InterPro DOMAIN/s: Zinc finger, LIM-type (InterPro:IPR001781), Ubiquitin interacting motif (InterPro:IPR003903), Protein of unknown function DUF3633 (InterPro:IPR022087); BEST Arabidopsis thaliana protein match is: LIM domain-containing protein (TAIR:AT4G36860.1); Has 3538 Blast hits to 2617 proteins in 167 species: Archae - 0; Bacteria - 18; Metazoa - 3009; Fungi - 63; Plants - 177; Viruses - 0; Other Eukaryotes - 271 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6662417..6666032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101785.4 → NP_173361.1  DA1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173361.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P0C7Q8, Q9LM99
      UniProtKB/TrEMBL
      A0A178WC71, A0A5S9V5C0
      Conserved Domains (3) summary
      cd09396
      Location:172 → 224
      LIM_DA1; The Lim domain of DA1
      PTZ00482
      Location:29 → 132
      PTZ00482; membrane-attack complex/perforin (MACPF) Superfamily; Provisional
      pfam12315
      Location:321 → 527
      DA1-like; Protein DA1

    2. NM_001332389.1 → NP_001320535.1  DA1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P0C7Q8, Q9LM99
      UniProtKB/TrEMBL
      A0A178WC71, A0A5S9V5C0
      Conserved Domains (3) summary
      cd09396
      Location:172 → 224
      LIM_DA1; The Lim domain of DA1
      PTZ00482
      Location:29 → 132
      PTZ00482; membrane-attack complex/perforin (MACPF) Superfamily; Provisional
      pfam12315
      Location:321 → 527
      DA1-like; Protein DA1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C7Q8.1

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