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    Toll-Interleukin-Resistance (TIR) domain family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834522, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Toll-Interleukin-Resistance (TIR) domain family protein
    Primary source
    TAIR:AT5G44920
    Locus tag
    AT5G44920
    See related
    Araport:AT5G44920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtTIK; K21C13.10; K21C13_10; TIK; TIR-KASH protein
    Summary
    Encodes a KASH domain protein that localizes to the nuclear envelope and affects nuclear morphology.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (18138775..18140190)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Toll-Interleukin-Resistance (TIR) domain family protein Neighboring gene Toll-Interleukin-Resistance (TIR) domain family protein Neighboring gene ncRNA Neighboring gene Exostosin family protein Neighboring gene pseudo Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of two distinct subfamilies of SUN-domain proteins in Arabidopsis and their interactions with the novel KASH-domain protein AtTIK. Graumann K, et al. J Exp Bot, 2014 Dec. PMID 25217773
    2. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
    3. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtTIK localizes to the nuclear envelope and affects nuclear morphology. [AtTIK]
      Title: Characterization of two distinct subfamilies of SUN-domain proteins in Arabidopsis and their interactions with the novel KASH-domain protein AtTIK.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_123860.2
    NM_180800.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Toll-Interleukin-Resistance (TIR) domain family protein
    NP_199305.2
    • Toll-Interleukin-Resistance (TIR) domain family protein; FUNCTIONS IN: transmembrane receptor activity; INVOLVED IN: signal transduction, defense response, innate immune response; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Toll-Interleukin receptor (InterPro:IPR000157); BEST Arabidopsis thaliana protein match is: Toll-Interleukin-Resistance (TIR) domain family protein (TAIR:AT4G19920.1); Has 1542 Blast hits to 1488 proteins in 47 species: Archae - 0; Bacteria - 4; Metazoa - 0; Fungi - 0; Plants - 1538; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).
    NP_851131.1
    • Toll-Interleukin-Resistance (TIR) domain family protein; FUNCTIONS IN: transmembrane receptor activity; INVOLVED IN: signal transduction, defense response, innate immune response; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Toll-Interleukin receptor (InterPro:IPR000157); BEST Arabidopsis thaliana protein match is: Toll-Interleukin-Resistance (TIR) domain family protein (TAIR:AT4G19920.1); Has 1563 Blast hits to 1505 proteins in 48 species: Archae - 0; Bacteria - 4; Metazoa - 0; Fungi - 0; Plants - 1558; Viruses - 0; Other Eukaryotes - 1 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18138775..18140190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180800.2 → NP_851131.1  Toll-Interleukin-Resistance (TIR) domain family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851131.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WSX8, Q9FLA6
      UniProtKB/TrEMBL
      A0A178UA72, A0A5S9YB28
      Conserved Domains (1) summary
      smart00255
      Location:12 → 154
      TIR; Toll - interleukin 1 - resistance

    2. NM_123860.2 → NP_199305.2  Toll-Interleukin-Resistance (TIR) domain family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199305.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9YB28, F4KBQ6
      Conserved Domains (1) summary
      smart00255
      Location:12 → 131
      TIR; Toll - interleukin 1 - resistance
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WSX8.1

    Gene LinkOut

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