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    UBC8 ubiquitin conjugating enzyme 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834173, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UBC8
    Official Full Name
    ubiquitin conjugating enzyme 8
    Primary source
    TAIR:AT5G41700
    Locus tag
    AT5G41700
    See related
    Araport:AT5G41700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA UBIQUITIN CONJUGATING ENZYME 8; ATUBC8; MBK23.24; MBK23_24; UBIQUITIN CONJUGATING ENZYME; ubiquitin conjugating enzyme 8
    Summary
    One of the polypeptides that constitute the ubiquitin-conjugating enzyme E2
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    Genomic context

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    See UBC8 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (16675582..16677525)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene Mitochondrial outer membrane translocase complex, subunit Tom7 Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene pseudo Neighboring gene F-box associated ubiquitination effector family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Homologs of the essential ubiquitin conjugating enzymes UBC1, 4, and 5 in yeast are encoded by a multigene family in Arabidopsis thaliana. Girod PA, et al. Plant J, 1993 Apr. PMID 8220461
    2. A mutation in NLA, which encodes a RING-type ubiquitin ligase, disrupts the adaptability of Arabidopsis to nitrogen limitation. Peng M, et al. Plant J, 2007 Apr. PMID 17355433
    3. Regulation of the new Arabidopsis imprinted gene AtBMI1C requires the interplay of different epigenetic mechanisms. Bratzel F, et al. Mol Plant, 2012 Jan. PMID 21914649
    4. Upregulation of an Arabidopsis RING-H2 gene, XERICO, confers drought tolerance through increased abscisic acid biosynthesis. Ko JH, et al. Plant J, 2006 Aug. PMID 16792696
    5. Suppression of Arabidopsis RING E3 ubiquitin ligase AtATL78 increases tolerance to cold stress and decreases tolerance to drought stress. Kim SJ, et al. FEBS Lett, 2013 Aug 19. PMID 23831064

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203518.1
    NM_123535.2
    NM_180783.2
    NM_180784.2
    NM_180785.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within endosperm development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin conjugating enzyme 8
    NP_001190447.1
    • ubiquitin conjugating enzyme 8 (UBC8); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 28 (TAIR:AT1G64230.2).
    NP_568595.2
    • ubiquitin conjugating enzyme 8 (UBC8); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 28 (TAIR:AT1G64230.2); Has 10671 Blast hits to 10632 proteins in 401 species: Archae - 0; Bacteria - 4; Metazoa - 4624; Fungi - 2337; Plants - 1940; Viruses - 26; Other Eukaryotes - 1740 (source: NCBI BLink).
    NP_851114.1
    • ubiquitin conjugating enzyme 8 (UBC8); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 28 (TAIR:AT1G64230.2); Has 10659 Blast hits to 10620 proteins in 402 species: Archae - 0; Bacteria - 4; Metazoa - 4622; Fungi - 2335; Plants - 1937; Viruses - 26; Other Eukaryotes - 1735 (source: NCBI BLink).
    NP_851115.1
    • ubiquitin conjugating enzyme 8 (UBC8); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 28 (TAIR:AT1G64230.2); Has 10659 Blast hits to 10620 proteins in 402 species: Archae - 0; Bacteria - 4; Metazoa - 4622; Fungi - 2335; Plants - 1937; Viruses - 26; Other Eukaryotes - 1735 (source: NCBI BLink).
    NP_851116.1
    • ubiquitin conjugating enzyme 8 (UBC8); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 10 (TAIR:AT5G53300.4); Has 10293 Blast hits to 10263 proteins in 395 species: Archae - 0; Bacteria - 4; Metazoa - 4446; Fungi - 2262; Plants - 1907; Viruses - 23; Other Eukaryotes - 1651 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16675582..16677525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203518.1 → NP_001190447.1  ubiquitin conjugating enzyme 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190447.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35131, Q3E8J2, Q3E8J3, Q42308, Q43276, Q4TZ02, Q8LE19
      UniProtKB/TrEMBL
      A0A178UE87, A0A178VAX4
      Conserved Domains (1) summary
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_180783.2 → NP_851114.1  ubiquitin conjugating enzyme 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851114.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35131, Q3E8J2, Q3E8J3, Q42308, Q43276, Q4TZ02, Q8LE19
      UniProtKB/TrEMBL
      A0A178UE87, A0A178VAX4
      Conserved Domains (1) summary
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_180785.2 → NP_851116.1  ubiquitin conjugating enzyme 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851116.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9DFD0
      Conserved Domains (2) summary
      COG5078
      Location:1 → 108
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cl00154
      Location:1 → 104
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    4. NM_123535.2 → NP_568595.2  ubiquitin conjugating enzyme 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568595.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35131
      Conserved Domains (2) summary
      COG5078
      Location:1 → 148
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cl00154
      Location:1 → 147
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    5. NM_180784.2 → NP_851115.1  ubiquitin conjugating enzyme 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851115.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35131, Q3E8J2, Q3E8J3, Q42308, Q43276, Q4TZ02, Q8LE19
      UniProtKB/TrEMBL
      A0A178UE87, A0A178VAX4
      Conserved Domains (1) summary
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35131.1

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