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    G6PD6 glucose-6-phosphate dehydrogenase 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834076, updated on 18-Sep-2024

    Summary

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    Official Symbol
    G6PD6
    Official Full Name
    glucose-6-phosphate dehydrogenase 6
    Primary source
    TAIR:AT5G40760
    Locus tag
    AT5G40760
    See related
    Araport:AT5G40760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    glucose-6-phosphate dehydrogenase 6; K1B16.1; K1B16_1
    Summary
    Encodes a cytosolic glucose-6-phosphate dehydrogenase that is insensitive to reduction by DTT and whose mRNA is expressed ubiquitously.
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    Genomic context

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    See G6PD6 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    17
    Sequence:
    Chromosome: 5; NC_003076.8 (16310663..16314811)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene HAUS augmin-like complex subunit Neighboring gene FBD / Leucine Rich Repeat domains containing protein Neighboring gene prohibitin 3 Neighboring gene lysine histidine transporter 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase isoform genes in suspension-cultured Arabidopsis thaliana cells. Yin Y, et al. Z Naturforsch C J Biosci, 2008 Sep-Oct. PMID 19040112
    2. Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in Arabidopsis. Dal Santo S, et al. Plant Cell, 2012 Aug. PMID 22885737, Free PMC Article
    3. Functional analyses of cytosolic glucose-6-phosphate dehydrogenases and their contribution to seed oil accumulation in Arabidopsis. Wakao S, et al. Plant Physiol, 2008 Jan. PMID 17993547, Free PMC Article
    4. Genome-wide analysis of glucose-6-phosphate dehydrogenases in Arabidopsis. Wakao S, et al. Plant J, 2005 Jan. PMID 15634201
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of G6PD6 alters the cellular redox state and renders plants more sensitive to high salt stress.
      Title: Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in Arabidopsis.
    2. Compared to the reduction of almost all isoform genes of G6PDH in inorganic phosphate-starved cultures, the reduction of 6PGDH genes was less severe.
      Title: Expression of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase isoform genes in suspension-cultured Arabidopsis thaliana cells.
    3. results suggest that loss of cytosolic G6PDH activity affects the metabolism of developing seeds by increasing carbon substrates for synthesis of storage compounds rather than by decreasing the NADPH supply specifically for fatty acid synthesis
      Title: Functional analyses of cytosolic glucose-6-phosphate dehydrogenases and their contribution to seed oil accumulation in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001344352.1
    NM_123441.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pentose-phosphate shunt, oxidative branch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glucose-6-phosphate dehydrogenase 6
    NP_198892.1
    • glucose-6-phosphate dehydrogenase 6 (G6PD6); CONTAINS InterPro DOMAIN/s: Glucose-6-phosphate dehydrogenase, C-terminal (InterPro:IPR022675), Glucose-6-phosphate dehydrogenase, active site (InterPro:IPR019796), NAD(P)-binding domain (InterPro:IPR016040), Glucose-6-phosphate dehydrogenase (InterPro:IPR001282), Glucose-6-phosphate dehydrogenase, NAD-binding (InterPro:IPR022674); BEST Arabidopsis thaliana protein match is: glucose-6-phosphate dehydrogenase 5 (TAIR:AT3G27300.3); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16310663..16314811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123441.3 → NP_198892.1  glucose-6-phosphate dehydrogenase 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198892.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FJI5, Q9SUJ9
      UniProtKB/TrEMBL
      A0A178UA94, A0A384LPG4, A0A5S9YAV9, Q0WSL0
      Conserved Domains (1) summary
      PLN02539
      Location:15 → 508
      PLN02539; glucose-6-phosphate 1-dehydrogenase

    2. NM_001344352.1 → NP_001330361.1  glucose-6-phosphate dehydrogenase 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FJI5, Q9SUJ9
      UniProtKB/TrEMBL
      A0A178UA94, A0A384LPG4, A0A5S9YAV9, Q0WSL0
      Conserved Domains (1) summary
      PLN02539
      Location:15 → 508
      PLN02539; glucose-6-phosphate 1-dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FJI5.1

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