CaS calcium sensing receptor [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CaS
Official Full Name: calcium sensing receptor
Primary source: TAIR:AT5G23060
Locus tag: AT5G23060
See related: Araport:AT5G23060
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: calcium sensing receptor; MYJ24.5; MYJ24_5
Summary: Encodes a chloroplast-localized protein that modulates cytoplasmic Ca2+ concentration and is crucial for proper stomatal regulation in response to elevations of external Ca2+. Phosphorylation of this protein is dependent on calcium.
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Genomic context

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See CaS in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 6

Sequence:: Chromosome: 5; NC_003076.8 (7736518..7738535, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Calcium-sensing receptor (CAS) regulates transpiration and optimizes photosynthesis by playing important roles in stomatal movement and formation of photosynthetic electron transport, thereby regulating WUE and drought tolerance.
Title: Regulation of the calcium-sensing receptor in both stomatal movement and photosynthetic electron transport is crucial for water use efficiency and drought tolerance in Arabidopsis.
A mutation in CAU1 significantly increased the expression level of the calcium signaling gene CAS, and functional disruption of CAS abolished the enhanced drought tolerance and stomatal [Ca(2+)]o signaling in cau1.
Title: Arabidopsis histone methylase CAU1/PRMT5/SKB1 acts as an epigenetic suppressor of the calcium signaling gene CAS to mediate stomatal closure in response to extracellular calcium.
CAS is a chloroplast-localized protein that is crucial for proper stomatal regulation in response to elevations of external Ca(2+).
Title: A plastid protein crucial for Ca2+-regulated stomatal responses.
Arabidopsis lines revealed a significant role for calcium-sensing receptor (CaS) in plant growth and development. [calcium-sensing receptor] [CaS]
Title: Light regulation of CaS, a novel phosphoprotein in the thylakoid membrane of Arabidopsis thaliana.
results show [Ca2+]i oscillations are synchronized to extracellular Ca2+ concentration oscillations largely through Ca2+-sensing receptor CAS; CAS regulates inositol 1,4,5-trisphosphate concentration which directs release of Ca2+ from internal stores
Title: Coupling diurnal cytosolic Ca2+ oscillations to the CAS-IP3 pathway in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001343788.1

Supported by ESTs:

NM_122212.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in de-etiolation	IEA Inferred from Electronic Annotation more info
involved_in de-etiolation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stomatal closure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of stomatal closure	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast thylakoid	HDA more info	PubMed
located_in chloroplast thylakoid membrane	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plastid	HDA more info	PubMed
located_in thylakoid	HDA more info	PubMed
located_in thylakoid	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcium sensing receptor

NP_197697.1

calcium sensing receptor (CaS); INVOLVED IN: regulation of stomatal closure, cellular response to calcium ion; LOCATED IN: thylakoid, mitochondrion, chloroplast thylakoid membrane, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Rhodanese-like (InterPro:IPR001763); BEST Arabidopsis thaliana protein match is: Rhodanese/Cell cycle control phosphatase superfamily protein (TAIR:AT3G59780.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

7736518..7738535 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_122212.5 → NP_197697.1 calcium sensing receptor [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_197697.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FN48

UniProtKB/TrEMBL

A0A178UBZ3, A0A5S9Y6T9, A0A654G3C2

Conserved Domains (1) summary

cd00158
Location:225 → 339

RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
NM_001343788.1 → NP_001331124.1 calcium sensing receptor [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UBZ3, A0A1P8BCX7