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    DOT2 SART-1 family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831541, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DOT2
    Official Full Name
    SART-1 family
    Primary source
    TAIR:AT5G16780
    Locus tag
    AT5G16780
    See related
    Araport:AT5G16780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DEFECTIVELY ORGANIZED TRIBUTARIES 2; DEFECTIVELY ORGANIZED TRIBUTARIES 2; F5E19.120; F5E19_120; MDF; MERISTEM-DEFECTIVE
    Summary
    Encodes a protein belonging to SART-1 family. The gene is expressed in the basal region of the developing embryo during heart stage. Phenotypic analyses of dot2 mutants suggest that this protein plays a role in root, shoot, and flower development. dot2 mutants are dwarved plants that display an aberrant spurred leaf venation pattern and fail to flower. In the roots DOT2 appears to be require for normal meristem organization and maintenance and the proper expression of PIN and PLT genes.
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    Genomic context

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    See DOT2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Sequence:
    Chromosome: 5; NC_003076.8 (5515707..5522261, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Transducin family protein / WD-40 repeat family protein Neighboring gene Inositol 1,3,4-trisphosphate 5/6-kinase family protein Neighboring gene myb domain protein 9 Neighboring gene Tho complex subunit 7/Mft1p Neighboring gene Acyl-CoA N-acyltransferases (NAT) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MDF is a conserved splicing factor and modulates cell division and stress response in Arabidopsis. de Luxán-Hernández C, et al. Life Sci Alliance, 2023 Jan. PMID 36265897, Free PMC Article
    2. MERISTEM-DEFECTIVE, an RS domain protein, is required for the correct meristem patterning and function in Arabidopsis. Casson SA, et al. Plant J, 2009 Mar. PMID 19000164
    3. Vein patterning screens and the defectively organized tributaries mutants in Arabidopsis thaliana. Petricka JJ, et al. Plant J, 2008 Oct. PMID 18643975
    4. Interactomics of Qa-SNARE in Arabidopsis thaliana. Fujiwara M, et al. Plant Cell Physiol, 2014 Apr. PMID 24556609
    5. Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions. Pendle AF, et al. Mol Biol Cell, 2005 Jan. PMID 15496452, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MDF is a conserved splicing factor and modulates cell division and stress response in Arabidopsis.
      Title: MDF is a conserved splicing factor and modulates cell division and stress response in Arabidopsis.
    2. MERISTEM-DEFECTIVE regulates PIN and meristem transcription factor gene expression, and establishes the correct auxin distribution, meristem pattern and function.
      Title: MERISTEM-DEFECTIVE, an RS domain protein, is required for the correct meristem patterning and function in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001343464.1
    NM_121684.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cotyledon vascular tissue pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf vascular tissue pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem or xylem histogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-embryonic root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within shoot system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SART-1 family
    NP_001318573.1
    • DEFECTIVELY ORGANIZED TRIBUTARIES 2 (DOT2); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: in 9 processes; LOCATED IN: nucleolus, nucleus; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: SART-1 protein (InterPro:IPR005011); BEST Arabidopsis thaliana protein match is: SART-1 family (TAIR:AT3G14700.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5515707..5522261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343465.1 → NP_001330040.1  SART-1 family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHM8, Q9ASS0, Q9LFE0
      UniProtKB/TrEMBL
      A0A178UP47, A0A5S9Y5F3, A0A654G2B7
      Conserved Domains (2) summary
      TIGR01622
      Location:38 → 148
      SF-CC1; splicing factor, CC1-like family
      pfam03343
      Location:171 → 727
      SART-1; SART-1 family

    2. NM_001343464.1 → NP_001318573.1  SART-1 family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHM8, Q9ASS0, Q9LFE0
      UniProtKB/TrEMBL
      A0A178UP47, A0A5S9Y5F3, A0A654G2B7
      Conserved Domains (2) summary
      TIGR01622
      Location:38 → 148
      SF-CC1; splicing factor, CC1-like family
      pfam03343
      Location:171 → 727
      SART-1; SART-1 family

    3. NM_121684.4 → NP_197180.1  SART-1 family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197180.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHM8, Q9ASS0, Q9LFE0
      UniProtKB/TrEMBL
      A0A178UP47, A0A5S9Y5F3, A0A654G2B7
      Conserved Domains (2) summary
      TIGR01622
      Location:38 → 148
      SF-CC1; splicing factor, CC1-like family
      pfam03343
      Location:171 → 727
      SART-1; SART-1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LFE0.1

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