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    ENTH/VHS family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831043, updated on 18-Sep-2024

    Summary

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    Official Full Name
    ENTH/VHS family protein
    Primary source
    TAIR:AT5G11710
    Locus tag
    AT5G11710
    See related
    Araport:AT5G11710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T22P22.100; T22P22_100
    Summary
    EPSIN1 plays an important role in the vacuolar trafficking of soluble proteins at the trans-Golgi network via its interaction with gamma-ADR, VTI11, VSR1, and clathrin. Associated with actin filaments and with the Golgi complex. Expressed in most tissues.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (3772401..3776671)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene translocase inner membrane subunit 17-3 Neighboring gene ephrin type-B receptor Neighboring gene Glycosyl hydrolases family 31 protein Neighboring gene Core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPSIN1 Modulates the Plasma Membrane Abundance of FLAGELLIN SENSING2 for Effective Immune Responses. Collins CA, et al. Plant Physiol, 2020 Apr. PMID 32094305, Free PMC Article
    2. EPSIN1 and MTV1 define functionally overlapping but molecularly distinct trans-Golgi network subdomains in Arabidopsis. Heinze L, et al. Proc Natl Acad Sci U S A, 2020 Oct 13. PMID 32989160, Free PMC Article
    3. Arabidopsis EPSIN1 plays an important role in vacuolar trafficking of soluble cargo proteins in plant cells via interactions with clathrin, AP-1, VTI11, and VSR1. Song J, et al. Plant Cell, 2006 Sep. PMID 16905657, Free PMC Article
    4. EpsinR2 interacts with clathrin, adaptor protein-3, AtVTI12, and phosphatidylinositol-3-phosphate. Implications for EpsinR2 function in protein trafficking in plant cells. Lee GJ, et al. Plant Physiol, 2007 Apr. PMID 17277094, Free PMC Article
    5. The deubiquitinating enzyme AMSH3 is required for intracellular trafficking and vacuole biogenesis in Arabidopsis thaliana. Isono E, et al. Plant Cell, 2010 Jun. PMID 20543027, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EPSIN1 and MTV1 define functionally overlapping but molecularly distinct trans-Golgi network subdomains in Arabidopsis.
      Title: EPSIN1 and MTV1 define functionally overlapping but molecularly distinct trans-Golgi network subdomains in Arabidopsis.
    2. EPSIN1 has a role in the vacuolar trafficking of soluble proteins at the trans-Golgi network via its interaction with gamma-ADR, VTI11, VSR1, and clathrin. [EPSIN1]
      Title: Arabidopsis EPSIN1 plays an important role in vacuolar trafficking of soluble cargo proteins in plant cells via interactions with clathrin, AP-1, VTI11, and VSR1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001343211.1
    NM_001343212.1
    NM_121209.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables clathrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables phospholipid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in thylakoid HDA PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ENTH/VHS family protein
    NP_001318545.1
    • ENTH/VHS family protein; FUNCTIONS IN: binding; INVOLVED IN: protein targeting to vacuole; LOCATED IN: thylakoid, actin filament, Golgi apparatus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Epsin, N-terminal (InterPro:IPR001026), Epsin-like, N-terminal (InterPro:IPR013809), ENTH/VHS (InterPro:IPR008942); BEST Arabidopsis thaliana protein match is: ENTH/VHS family protein (TAIR:AT2G43160.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      3772401..3776671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343211.1 → NP_001318545.1  ENTH/VHS family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WLJ9, Q8VY07, Q9LYF9
      UniProtKB/TrEMBL
      A0A5S9Y3D3, A0A654G0G8
      Conserved Domains (1) summary
      cd03571
      Location:28 → 144
      ENTH; Epsin N-Terminal Homology (ENTH) domain family

    2. NM_001343212.1 → NP_001331892.1  ENTH/VHS family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WLJ9, Q8VY07, Q9LYF9
      UniProtKB/TrEMBL
      A0A5S9Y3D3, A0A654G0G8
      Conserved Domains (1) summary
      cd03571
      Location:28 → 144
      ENTH; Epsin N-Terminal Homology (ENTH) domain family

    3. NM_121209.6 → NP_196732.2  ENTH/VHS family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196732.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WLJ9, Q8VY07, Q9LYF9
      UniProtKB/TrEMBL
      A0A5S9Y3D3, A0A654G0G8
      Conserved Domains (1) summary
      cd03571
      Location:28 → 144
      ENTH; Epsin N-Terminal Homology (ENTH) domain family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VY07.1

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