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    IDH1 isocitrate dehydrogenase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829679, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IDH1
    Official Full Name
    isocitrate dehydrogenase 1
    Primary source
    TAIR:AT4G35260
    Locus tag
    AT4G35260
    See related
    Araport:AT4G35260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F23E12.180; F23E12_180; IDH-I; isocitrate dehydrogenase 1; isocitrate dehydrogenase I; NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 1
    Summary
    Encodes a regulatory subunit of the mitochondrially-localized NAD+- dependent isocitrate dehydrogenase.
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    Genomic context

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    See IDH1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (16774142..16776371, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase subunit beta, putative (DUF630 and DUF632) Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene Plant regulator RWP-RK family protein Neighboring gene C2H2-like zinc finger protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NAD-dependent isocitrate dehydrogenase mutants of Arabidopsis suggest the enzyme is not limiting for nitrogen assimilation. Lemaitre T, et al. Plant Physiol, 2007 Jul. PMID 17468208, Free PMC Article
    2. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article
    3. Analysis of the Arabidopsis mitochondrial proteome. Millar AH, et al. Plant Physiol, 2001 Dec. PMID 11743115, Free PMC Article
    4. Proximity labeling of protein complexes and cell-type-specific organellar proteomes in Arabidopsis enabled by TurboID. Mair A, et al. Elife, 2019 Sep 19. PMID 31535972, Free PMC Article
    5. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Leaf IDH activity reduced by 60% in mutant
      Title: NAD-dependent isocitrate dehydrogenase mutants of Arabidopsis suggest the enzyme is not limiting for nitrogen assimilation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119692.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    contributes_to isocitrate dehydrogenase (NAD+) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within isocitrate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tricarboxylic acid cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    isocitrate dehydrogenase 1
    NP_195252.1
    • isocitrate dehydrogenase 1 (IDH1); CONTAINS InterPro DOMAIN/s: Isocitrate/isopropylmalate dehydrogenase (InterPro:IPR001804), Isocitrate dehydrogenase NAD-dependent, mitochondrial (InterPro:IPR004434); BEST Arabidopsis thaliana protein match is: isocitrate dehydrogenase subunit 2 (TAIR:AT2G17130.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16774142..16776371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119692.3 → NP_195252.1  isocitrate dehydrogenase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195252.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65501, P94015, Q7DM90, Q8LFC0
      UniProtKB/TrEMBL
      A0A178UVS2, A0A5S9XZ68
      Conserved Domains (1) summary
      PLN00123
      Location:8 → 367
      PLN00123; isocitrate dehydrogenase (NAD+)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LFC0.2

    Gene LinkOut

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