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    LAP2 Cytosol aminopeptidase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829216, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LAP2
    Official Full Name
    Cytosol aminopeptidase family protein
    Primary source
    TAIR:AT4G30920
    Locus tag
    AT4G30920
    See related
    Araport:AT4G30920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtLAP2; F6I18.170; F6I18_170; leucyl aminopeptidase 2
    Summary
    Encodes LAP2, an aminopeptidase playing key roles in senescence, stress response and amino acid turnover.
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    Genomic context

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    See LAP2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (15046457..15049438, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-specific protease 24 Neighboring gene DNAse I-like superfamily protein Neighboring gene Cytosol aminopeptidase family protein Neighboring gene Ribosomal protein L21 Neighboring gene WRKY DNA-binding protein 32

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of the Arabidopsis leucine aminopeptidase 2. Waditee-Sirisattha R, et al. Plant Signal Behav, 2011 Oct. PMID 21918372, Free PMC Article
    2. The Arabidopsis aminopeptidase LAP2 regulates plant growth, leaf longevity and stress response. Waditee-Sirisattha R, et al. New Phytol, 2011 Sep. PMID 21569035
    3. Plant leucine aminopeptidases moonlight as molecular chaperones to alleviate stress-induced damage. Scranton MA, et al. J Biol Chem, 2012 May 25. PMID 22493451, Free PMC Article
    4. A multi-step peptidolytic cascade for amino acid recovery in chloroplasts. Teixeira PF, et al. Nat Chem Biol, 2017 Jan. PMID 27820795
    5. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. M17.20 (AT4G30920) is specific towards non-polar and aromatic amino acids; is dually-targeted to mitochondria and chloroplasts; in chloroplasts M17.20 plays a role in amino acid recovery as a part of a multi-step peptidolytic cascade. [M17.20]
      Title: A multi-step peptidolytic cascade for amino acid recovery in chloroplasts.
    2. This work indicates an important in planta role for AtLAP2 contributing to a further understanding of the proteases having several implications in higher plants.
      Title: Role of the Arabidopsis leucine aminopeptidase 2.
    3. LAP2 (AT4G30920) influences cell wall metabolism and components of cell growth, photosynthesis, and nitrogen metabolism. Loss of function accelerates leaf senescence and renders plants more sensitive to various stresses.
      Title: The Arabidopsis aminopeptidase LAP2 regulates plant growth, leaf longevity and stress response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_119239.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    Cytosol aminopeptidase family protein
    NP_194821.1
    • Cytosol aminopeptidase family protein; FUNCTIONS IN: manganese ion binding, metalloexopeptidase activity, aminopeptidase activity; INVOLVED IN: proteolysis, protein metabolic process; LOCATED IN: chloroplast, vacuole; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: Peptidase M17, leucyl aminopeptidase, C-terminal (InterPro:IPR000819), Peptidase M17, leucyl aminopeptidase, N-terminal (InterPro:IPR008283), Peptidase M17, leucyl aminopeptidase (InterPro:IPR011356); BEST Arabidopsis thaliana protein match is: Cytosol aminopeptidase family protein (TAIR:AT4G30910.1); Has 9817 Blast hits to 9813 proteins in 2024 species: Archae - 18; Bacteria - 5432; Metazoa - 663; Fungi - 36; Plants - 122; Viruses - 1; Other Eukaryotes - 3545 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15046457..15049438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119239.3 → NP_194821.1  Cytosol aminopeptidase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194821.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65557, Q944P7
      UniProtKB/TrEMBL
      A0A5S9XXW6, A0A654FUF0
      Conserved Domains (1) summary
      PRK00913
      Location:81 → 579
      PRK00913; multifunctional aminopeptidase A; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q944P7.2

    Gene LinkOut

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