GGT4 gamma-glutamyl transpeptidase 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GGT4
Official Full Name: gamma-glutamyl transpeptidase 4
Primary source: TAIR:AT4G29210
Locus tag: AT4G29210
See related: Araport:AT4G29210
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F17A13.30; F17A13_30; gamma-glutamyl transpeptidase 3; gamma-glutamyl transpeptidase 4; GGT3
Summary: The gene encodes a gamma-glutamyltransferase (AKA gamma-glutamyl transpeptidase, EC 2.3.2.2) that is located in the vacuole and is most active in roots. The encoded enzyme is involved in the initial degradation of glutathione conjugates in this cell compartment. It is also induced by xenobiotics and contributes to xenobiotics metabolism. Note that conflicting nomenclature exists in the literature: At4g29210 is named as GGT3 in Plant J. 2007 Mar 49(5):878-88; At4g29210 is named as GGT4 and At1g69820 as GGT3 in Plant Physiol. 2007 Aug 144(4):1715-32.
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Genomic context

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See GGT4 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 4

Sequence:: Chromosome: 4; NC_003075.7 (14400920..14403519)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study identifies gamma-glutamyl transpeptidase 4 (At4g29210, GGT4) as the first step of vacuolar degradation of glutathione conjugates [GGT4]
Title: gamma-Glutamyl transpeptidase GGT4 initiates vacuolar degradation of glutathione S-conjugates in Arabidopsis.
This study identifies gamma-glutamyltransferase 3 as catalyzing the obligate initial step in glutathione conjugate metabolism, and suggests that it has an important role in protecting plants from some xenobiotic chemicals.
Title: Glutathione conjugates in the vacuole are degraded by gamma-glutamyl transpeptidase GGT3 in Arabidopsis.

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

NM_119065.3

Supported by ESTs:

NM_202907.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables glutathione gamma-glutamylcysteinyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione hydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables leukotriene C4 gamma-glutamyl transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glutathione catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within xenobiotic metabolic process	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in vacuole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gamma-glutamyl transpeptidase 4

NP_194650.1

gamma-glutamyl transpeptidase 4 (GGT4); CONTAINS InterPro DOMAIN/s: Gamma-glutamyltranspeptidase (InterPro:IPR000101); BEST Arabidopsis thaliana protein match is: gamma-glutamyl transpeptidase 1 (TAIR:AT4G39640.2); Has 9173 Blast hits to 9142 proteins in 1473 species: Archae - 86; Bacteria - 4214; Metazoa - 707; Fungi - 305; Plants - 112; Viruses - 1; Other Eukaryotes - 3748 (source: NCBI BLink).

NP_974636.1

gamma-glutamyl transpeptidase 4 (GGT4); CONTAINS InterPro DOMAIN/s: Gamma-glutamyltranspeptidase (InterPro:IPR000101); BEST Arabidopsis thaliana protein match is: gamma-glutamyl transpeptidase 1 (TAIR:AT4G39640.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

14400920..14403519

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_202907.2 → NP_974636.1 gamma-glutamyl transpeptidase 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974636.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9M0G0

Conserved Domains (1) summary

cl19223
Location:1 → 497

G_glu_transpept; Gamma-glutamyltranspeptidase
NM_119065.3 → NP_194650.1 gamma-glutamyl transpeptidase 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194650.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4JMW7, Q9M0G0

UniProtKB/TrEMBL

A0A178UZT3, A0A7G2F4N3

Conserved Domains (1) summary

cl19223
Location:1 → 637

G_glu_transpept; Gamma-glutamyltranspeptidase