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    TYRDC L-tyrosine decarboxylase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828986, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TYRDC
    Official Full Name
    L-tyrosine decarboxylase
    Primary source
    TAIR:AT4G28680
    Locus tag
    AT4G28680
    See related
    Araport:AT4G28680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtTYDC; L-tyrosine decarboxylase; L-TYROSINE DECARBOXYLASE 1; T5F17.130; T5F17_130; TYDC; TYRDC1
    Summary
    Encodes a stress-induced tyrosine decarboxylase (TyrDC). Recombinant (His)6-TyrDC expressed in E. coli catalyzes the conversion of L-tyrosine to tyramine. Recombinant TyrDC forms tetramers.
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    Genomic context

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    See TYRDC in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    11
    Sequence:
    Chromosome: 4; NC_003075.7 (14155064..14158869)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene photosystem II reaction center PSB28 protein Neighboring gene cysteine-rich RECEPTOR-like kinase, putative (DUF26) Neighboring gene uncharacterized protein Neighboring gene ammonium transporter 1;4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene expression and characterization of a stress-induced tyrosine decarboxylase from Arabidopsis thaliana. Lehmann T, et al. FEBS Lett, 2009 Jun 18. PMID 19450582
    2. Role of aromatic aldehyde synthase in wounding/herbivory response and flower scent production in different Arabidopsis ecotypes. Gutensohn M, et al. Plant J, 2011 May. PMID 21284755
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TYDC knock-out mutants are deficient in tyramine synthesis.
      Title: Role of aromatic aldehyde synthase in wounding/herbivory response and flower scent production in different Arabidopsis ecotypes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001084992.1
    NM_119010.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables aromatic-L-amino-acid decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyrosine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tyrosine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within tyramine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    L-tyrosine decarboxylase
    NP_001078461.1
    • L-tyrosine decarboxylase (TYRDC); CONTAINS InterPro DOMAIN/s: Aromatic-L-amino-acid decarboxylase (InterPro:IPR010977), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Pyridoxal phosphate-dependent decarboxylase (InterPro:IPR002129), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate (PLP)-dependent transferases superfamily protein (TAIR:AT2G20340.1); Has 8315 Blast hits to 6320 proteins in 1946 species: Archae - 163; Bacteria - 2600; Metazoa - 2483; Fungi - 771; Plants - 335; Viruses - 8; Other Eukaryotes - 1955 (source: NCBI BLink).
    NP_001190861.1
    • L-tyrosine decarboxylase (TYRDC); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aromatic-L-amino-acid decarboxylase (InterPro:IPR010977), Pyridoxal phosphate-dependent decarboxylase (InterPro:IPR002129), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate (PLP)-dependent transferases superfamily protein (TAIR:AT2G20340.1).
    NP_001190862.1
    • L-tyrosine decarboxylase (TYRDC); CONTAINS InterPro DOMAIN/s: Aromatic-L-amino-acid decarboxylase (InterPro:IPR010977), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Pyridoxal phosphate-dependent decarboxylase (InterPro:IPR002129), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate (PLP)-dependent transferases superfamily protein (TAIR:AT2G20340.1).
    NP_194597.1
    • L-tyrosine decarboxylase (TYRDC); CONTAINS InterPro DOMAIN/s: Aromatic-L-amino-acid decarboxylase (InterPro:IPR010977), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Pyridoxal phosphate-dependent decarboxylase (InterPro:IPR002129), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate (PLP)-dependent transferases superfamily protein (TAIR:AT2G20340.1); Has 8292 Blast hits to 6272 proteins in 1930 species: Archae - 160; Bacteria - 2569; Metazoa - 2508; Fungi - 762; Plants - 340; Viruses - 8; Other Eukaryotes - 1945 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      14155064..14158869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341927.1 → NP_001329473.1  L-tyrosine decarboxylase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B7T4, A0A5S9XX47, A0A654FU52
      Conserved Domains (1) summary
      PLN02590
      Location:2 → 566
      PLN02590; probable tyrosine decarboxylase

    2. NM_001341929.1 → NP_001329472.1  L-tyrosine decarboxylase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B7T5
      Conserved Domains (1) summary
      cl18945
      Location:2 → 388
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    3. NM_001203933.2 → NP_001190862.1  L-tyrosine decarboxylase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190862.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FU52, F4JM08
      Conserved Domains (1) summary
      PLN02590
      Location:2 → 538
      PLN02590; probable tyrosine decarboxylase

    4. NM_001341928.1 → NP_001329474.1  L-tyrosine decarboxylase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B7T7

    5. NM_001203932.1 → NP_001190861.1  L-tyrosine decarboxylase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190861.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FU52, F4JM09
      Conserved Domains (1) summary
      PLN02590
      Location:7 → 547
      PLN02590; probable tyrosine decarboxylase

    6. NM_001084992.1 → NP_001078461.1  L-tyrosine decarboxylase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078461.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FU52, A8MQJ1
      Conserved Domains (1) summary
      PLN02590
      Location:7 → 547
      PLN02590; probable tyrosine decarboxylase

    7. NM_119010.3 → NP_194597.1  L-tyrosine decarboxylase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194597.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M0G4
      UniProtKB/TrEMBL
      A0A654FU52
      Conserved Domains (1) summary
      PLN02590
      Location:7 → 545
      PLN02590; probable tyrosine decarboxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M0G4.1

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