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    MC2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828614, updated on 11-Sep-2024

    Summary

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    Official Symbol
    MC2
    Primary source
    TAIR:AT4G25110
    Locus tag
    AT4G25110
    See related
    Araport:AT4G25110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtMC2; AtMCP1c; F24A6.7; MCP1c; metacaspase 1c; metacaspase 2
    Summary
    Encodes a type I metacaspase. Two Arabidopsis metacaspases, AT1G02170 (MC1) and AT4G25110 (MC2) antagonistically control programmed cell death in Arabidopsis. MC1 is a positive regulator of cell death and requires conserved caspase-like putative catalytic residues for its function. MC2 negatively regulates cell death. This function is independent of the putative catalytic residues. A third type I Arabidopsis metacaspase is MC3 (AT5g64240).
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (12887474..12890262, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene magnesium-protoporphyrin IX methyltransferase Neighboring gene Riboflavin synthase-like superfamily protein Neighboring gene Fe superoxide dismutase 1 Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene peptide met sulfoxide reductase 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis type I metacaspases control cell death. Coll NS, et al. Science, 2010 Dec 3. PMID 21097903
    2. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_001036634.1
    NM_118643.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metacaspase 2
    NP_001031711.1
    • metacaspase 2 (MC2); FUNCTIONS IN: cysteine-type endopeptidase activity; INVOLVED IN: proteolysis; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, LSD1-type (InterPro:IPR005735), Peptidase C14, caspase catalytic (InterPro:IPR011600); BEST Arabidopsis thaliana protein match is: metacaspase 1 (TAIR:AT1G02170.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_194241.3
    • metacaspase 2 (MC2); FUNCTIONS IN: cysteine-type endopeptidase activity; INVOLVED IN: proteolysis; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C14, caspase catalytic (InterPro:IPR011600), Zinc finger, LSD1-type (InterPro:IPR005735); BEST Arabidopsis thaliana protein match is: metacaspase 1 (TAIR:AT1G02170.1); Has 7673 Blast hits to 3913 proteins in 538 species: Archae - 9; Bacteria - 793; Metazoa - 961; Fungi - 920; Plants - 3202; Viruses - 585; Other Eukaryotes - 1203 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12887474..12890262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118643.5 → NP_194241.3  metacaspase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194241.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q682S4, Q7XJE5, Q9SW15
      UniProtKB/TrEMBL
      A0A178V2G1, A0A5S9XVM7
      Conserved Domains (2) summary
      TIGR01053
      Location:4 → 34
      LSD1; zinc finger domain, LSD1 subclass
      pfam00656
      Location:116 → 352
      Peptidase_C14; Caspase domain

    2. NM_001036634.1 → NP_001031711.1  metacaspase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031711.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7XJE5
      Conserved Domains (2) summary
      TIGR01053
      Location:4 → 34
      LSD1; zinc finger domain, LSD1 subclass
      pfam00656
      Location:116 → 349
      Peptidase_C14; Caspase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7XJE5.1

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