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    NPR4 NPR1-like protein 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827710, updated on 18-Sep-2024

    Summary

    Official Symbol
    NPR4
    Official Full Name
    NPR1-like protein 4
    Primary source
    TAIR:AT4G19660
    Locus tag
    AT4G19660
    See related
    Araport:AT4G19660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATNPR4; NPR1-like protein 4; T16H5.20; T16H5_20
    Summary
    Encodes NPR4, a ankyrin repeat BTB/POZ domain-containing protein with 36% sequence identity with NPR1. Mutants are more susceptible to the bacterial pathogen Pseudomonas syringe pv. tomato DC3000 and to the fungal pathogen Erysiphe cichoracearum, but do not differ markedly from wild type in interaction with virulent and avirulent strains of the oomycete Peronospora parasitica. NPR4 is required for basal defense against pathogens, and may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways. NPR3 and NPR4 are receptors for the immune signal salicylic acid.
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    Genomic context

    See NPR4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (10696266..10698811, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Ras-related small GTP-binding family protein Neighboring gene TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein Neighboring gene Mitochondrial transcription termination factor family protein Neighboring gene RING/U-box superfamily protein Neighboring gene iron regulated transporter 2

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    NM_001341366.1
    NM_118086.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables salicylic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables salicylic acid binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of jasmonic acid mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of jasmonic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of salicylic acid mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of salicylic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of systemic acquired resistance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to salicylic acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within systemic acquired resistance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in systemic acquired resistance, salicylic acid mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    NPR1-like protein 4
    NP_193701.2
    • NPR1-like protein 4 (NPR4); CONTAINS InterPro DOMAIN/s: BTB/POZ (InterPro:IPR013069), NPR1/NIM1 like, C-terminal (InterPro:IPR021094), BTB/POZ fold (InterPro:IPR011333), Ankyrin repeat-containing domain (InterPro:IPR020683), BTB/POZ-like (InterPro:IPR000210), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: NPR1-like protein 3 (TAIR:AT5G45110.1); Has 1751 Blast hits to 1617 proteins in 183 species: Archae - 0; Bacteria - 140; Metazoa - 493; Fungi - 63; Plants - 647; Viruses - 2; Other Eukaryotes - 406 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10696266..10698811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118086.3NP_193701.2  NPR1-like protein 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81848, Q5ICL9
      UniProtKB/TrEMBL
      A0A178UZK3
      Conserved Domains (7) summary
      pfam11900
      Location:215258
      DUF3420; Domain of unknown function (DUF3420)
      smart00225
      Location:55179
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd00204
      Location:260352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12313
      Location:357551
      NPR1_like_C; NPR1/NIM1 like defence protein C terminal
      pfam13857
      Location:302355
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:284313
      ANK; ANK repeat [structural motif]
      cl02518
      Location:42133
      BTB; BTB/POZ domain
    2. NM_001341366.1NP_001328027.1  NPR1-like protein 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3C8, A0A654FQW9
      Conserved Domains (7) summary
      pfam11900
      Location:215258
      DUF3420; Domain of unknown function (DUF3420)
      smart00225
      Location:55179
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd00204
      Location:260352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12313
      Location:357578
      NPR1_like_C; NPR1/NIM1 like defence protein C terminal
      pfam13857
      Location:302355
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:284313
      ANK; ANK repeat [structural motif]
      cl02518
      Location:42133
      BTB; BTB/POZ domain