WRKY19 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: WRKY19
Primary source: TAIR:AT4G12020
Locus tag: AT4G12020
See related: Araport:AT4G12020
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATWRKY19; F16J13.90; F16J13_90; MAPK/ERK KINASE KINASE 4; MAPKKK11; MEKK4; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 11
Summary: Encodes a member of the A1 subgroup of the MEKK (MAPK/ERK kinase kinase) family. MEKK is another name for Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK or MAP3K). This subgroup has four members: At4g08500 (MEKK1, also known as ARAKIN, MAP3Kb1, MAPKKK8), At4g08480 (MEKK2, also known as MAP3Kb4, MAPKKK9), At4g08470 (MEKK3, also known as MAP3Kb3, MAPKKK10) and At4g12020 (MEKK4, also known as MAP3Kb5, MAPKKK11, WRKY19). Nomenclatures for mitogen-activated protein kinases are described in Trends in Plant Science 2002,7(7):301.
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Genomic context

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Location:: chromosome: 4

Exon count:: 15

Sequence:: Chromosome: 4; NC_003075.7 (7201522..7209692)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The TIR-NB-LRR pair DSC1 and WRKY19 contributes to basal immunity of Arabidopsis to the root-knot nematode Meloidogyne incognita. [WRKY19]
Title: The TIR-NB-LRR pair DSC1 and WRKY19 contributes to basal immunity of Arabidopsis to the root-knot nematode Meloidogyne incognita.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001125496.2

Supported by ESTs:

NM_001160750.1

Supported by ESTs:

NM_001340761.1

Supported by ESTs:

NM_117272.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ADP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: protein kinase family protein

NP_001118968.1

WRKY19; FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 7 processes; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Serine/threonine-protein kinase domain (InterPro:IPR002290), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Disease resistance protein (InterPro:IPR000767), Toll-Interleukin receptor (InterPro:IPR000157), Protein kinase-like domain (InterPro:IPR011009), DNA-binding WRKY (InterPro:IPR003657), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Paired amphipathic helix (InterPro:IPR003822); BEST Arabidopsis thaliana protein match is: MAPK/ERK kinase kinase 1 (TAIR:AT4G08500.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_001154222.1

WRKY19; FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 7 processes; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Serine/threonine-protein kinase domain (InterPro:IPR002290), NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767), Protein kinase-like domain (InterPro:IPR011009), DNA-binding WRKY (InterPro:IPR003657), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Paired amphipathic helix (InterPro:IPR003822); BEST Arabidopsis thaliana protein match is: MAPK/ERK kinase kinase 1 (TAIR:AT4G08500.1); Has 161171 Blast hits to 143588 proteins in 4409 species: Archae - 136; Bacteria - 15922; Metazoa - 51225; Fungi - 11654; Plants - 60280; Viruses - 540; Other Eukaryotes - 21414 (source: NCBI BLink).

NP_192939.2

WRKY19; FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 7 processes; LOCATED IN: chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Disease resistance protein (InterPro:IPR000767), Toll-Interleukin receptor (InterPro:IPR000157), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), DNA-binding WRKY (InterPro:IPR003657), ATPase, AAA+ type, core (InterPro:IPR003593), Protein kinase, catalytic domain (InterPro:IPR000719), EGF-like (InterPro:IPR006210), Paired amphipathic helix (InterPro:IPR003822); BEST Arabidopsis thaliana protein match is: nucleoside-triphosphatases;transmembrane receptors;nucleotide binding;ATP binding (TAIR:AT4G19500.1); Has 144103 Blast hits to 127280 proteins in 3862 species: Archae - 77; Bacteria - 12337; Metazoa - 45865; Fungi - 10852; Plants - 56227; Viruses - 349; Other Eukaryotes - 18396 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

7201522..7209692

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001340762.1 → NP_001329652.1 protein kinase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B8D3, A0A654FNK5
NM_001340763.1 → NP_001329653.1 protein kinase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UVS6, A0A1P8B8D2
NM_001340764.1 → NP_001329654.1 protein kinase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UVS6, A0A1P8B8D4
NM_001340766.1 → NP_001329656.1 protein kinase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UVS6, A0A1P8B8D4
NM_001340765.1 → NP_001329655.1 protein kinase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UVS6, A0A1P8B8E0
NM_001340767.1 → NP_001329657.1 protein kinase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UVS6, B3H4T8
NM_001340760.1 → NP_001329658.1 protein kinase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B8G5, A0A654FNK5
NM_001125496.2 → NP_001118968.1 protein kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001118968.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SZ67

UniProtKB/TrEMBL

A0A654FNK5

Conserved Domains (6) summary

smart00220
Location:1626 → 1877

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00774
Location:467 → 523

WRKY; DNA binding domain

PLN03210
Location:663 → 1448

PLN03210; Resistant to P. syringae 6; Provisional

sd00033
Location:1260 → 1282

LRR_RI; leucine-rich repeat [structural motif]

pfam02671
Location:324 → 368

PAH; Paired amphipathic helix repeat

cl21453
Location:1626 → 1877

PKc_like; Protein Kinases, catalytic domain
NM_001160750.1 → NP_001154222.1 protein kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001154222.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654FNK5, F4JPV9

Conserved Domains (6) summary

smart00220
Location:1626 → 1861

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00774
Location:467 → 523

WRKY; DNA binding domain

PLN03210
Location:663 → 1448

PLN03210; Resistant to P. syringae 6; Provisional

sd00033
Location:1260 → 1282

LRR_RI; leucine-rich repeat [structural motif]

pfam02671
Location:324 → 368

PAH; Paired amphipathic helix repeat

cl21453
Location:1626 → 1861

PKc_like; Protein Kinases, catalytic domain
NM_117272.3 → NP_192939.2 protein kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_192939.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UVS6, B3H4T8

Conserved Domains (8) summary

smart00220
Location:1626 → 1790

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00774
Location:467 → 523

WRKY; DNA binding domain

PLN03210
Location:663 → 1448

PLN03210; Resistant to P. syringae 6; Provisional

sd00033
Location:1260 → 1282

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1229 → 1252

LRR_AMN1; leucine-rich repeat [structural motif]

pfam01582
Location:668 → 803

TIR; TIR domain

pfam02671
Location:324 → 368

PAH; Paired amphipathic helix repeat

cl21453
Location:1626 → 1796

PKc_like; Protein Kinases, catalytic domain
NM_001340761.1 → NP_001329659.1 protein kinase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B8F0