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    ATG6 AUTOPHAGY 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825344, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATG6
    Official Full Name
    AUTOPHAGY 6
    Primary source
    TAIR:AT3G61710
    Locus tag
    AT3G61710
    See related
    Araport:AT3G61710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATATG6; AtBECLIN1; AUTOPHAGY 6; BECLIN1; F21F14.6
    Summary
    Encodes autophagy protein 6 (ATG6), required for pollen germination and plant development.
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    Genomic context

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    See ATG6 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (22839232..22842446, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene helicase with zinc finger protein Neighboring gene tRNA-Gly Neighboring gene Ca2+dependent plant phosphoribosyltransferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis BECLIN1-induced autophagy mediates reprogramming in tapetal programmed cell death by altering the gross cellular homeostasis. Singh SP, et al. Plant Physiol Biochem, 2024 Mar. PMID 38503186
    2. Autophagy protein 6 (ATG6) is required for pollen germination in Arabidopsis thaliana. Harrison-Lowe NJ, et al. Autophagy, 2008 Apr. PMID 18227644
    3. Arabidopsis AtBECLIN 1/AtAtg6/AtVps30 is essential for pollen germination and plant development. Qin G, et al. Cell Res, 2007 Mar. PMID 17339883
    4. An Arabidopsis homolog of yeast ATG6/VPS30 is essential for pollen germination. Fujiki Y, et al. Plant Physiol, 2007 Mar. PMID 17259285, Free PMC Article
    5. Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase. Li F, et al. Nat Commun, 2018 Mar 28. PMID 29593293, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis BECLIN1-induced autophagy mediates reprogramming in tapetal programmed cell death by altering the gross cellular homeostasis.
      Title: Arabidopsis BECLIN1-induced autophagy mediates reprogramming in tapetal programmed cell death by altering the gross cellular homeostasis.
    2. Beclin1 restricts viral infection through suppression and also likely autophagic degradation of the viral RdRp
      Title: Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase.
    3. the Arabidopsis ATG6 homolog is an essential gene required for pollen germination and plant development.
      Title: Autophagy protein 6 (ATG6) is required for pollen germination in Arabidopsis thaliana.
    4. Arabidopsis Atg6/Vps30 functions not only in autophagy, but also plays a pivotal role in pollen germination.
      Title: An Arabidopsis homolog of yeast ATG6/VPS30 is essential for pollen germination.
    5. AtBECLIN 1 is required for normal plant development; genes related to autophagy, VPS and the glycosylphosphatidylinositol anchor system, were affected by the deficiency of AtBECLIN 1.
      Title: Arabidopsis AtBECLIN 1/AtAtg6/AtVps30 is essential for pollen germination and plant development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001035837.1
    NM_001340123.1
    NM_116036.4
    NM_202746.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AUTOPHAGY 6
    NP_001030914.1
    • BECLIN1 (BECLIN1); CONTAINS InterPro DOMAIN/s: Autophagy-related protein 6 (InterPro:IPR007243); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_567116.1
    • AUTOPHAGY 6 (ATG6); CONTAINS InterPro DOMAIN/s: Autophagy-related protein 6 (InterPro:IPR007243); Has 1006 Blast hits to 978 proteins in 347 species: Archae - 9; Bacteria - 233; Metazoa - 313; Fungi - 165; Plants - 83; Viruses - 12; Other Eukaryotes - 191 (source: NCBI BLink).
    NP_974475.1
    • BECLIN1 (BECLIN1); CONTAINS InterPro DOMAIN/s: Autophagy-related protein 6 (InterPro:IPR007243); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      22839232..22842446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116036.4 → NP_567116.1  AUTOPHAGY 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567116.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MRV3, F4JFF7, Q94BW8, Q9M367
      UniProtKB/TrEMBL
      A0A5S9XMV3, A0A654FJW7
      Conserved Domains (2) summary
      pfam04111
      Location:304 → 475
      APG6; Autophagy protein Apg6
      pfam17675
      Location:170 → 298
      APG6_N; Apg6 coiled-coil region

    2. NM_001340123.1 → NP_001327722.1  AUTOPHAGY 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LT68
      Conserved Domains (2) summary
      pfam04111
      Location:304 → 437
      APG6; Autophagy protein Apg6
      pfam17675
      Location:170 → 298
      APG6_N; Apg6 coiled-coil region

    3. NM_202746.2 → NP_974475.1  AUTOPHAGY 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974475.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M367
      Conserved Domains (2) summary
      pfam04111
      Location:304 → 363
      APG6; Autophagy protein Apg6
      pfam17675
      Location:170 → 298
      APG6_N; Apg6 coiled-coil region

    4. NM_001035837.1 → NP_001030914.1  AUTOPHAGY 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030914.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M367
      Conserved Domains (1) summary
      pfam04111
      Location:102 → 295
      APG6; Autophagy protein Apg6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M367.2

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