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    Cation efflux family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824975, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Cation efflux family protein
    Primary source
    TAIR:AT3G58060
    Locus tag
    AT3G58060
    See related
    Araport:AT3G58060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    8
    Sequence:
    Chromosome: 3; NC_003074.8 (21497633..21499943, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tonoplast-associated calcium signaling regulates manganese homeostasis in Arabidopsis. Zhang Z, et al. Mol Plant, 2021 May 3. PMID 33676025
    2. The Arabidopsis MTP8 transporter determines the localization of manganese and iron in seeds. Chu HH, et al. Sci Rep, 2017 Sep 8. PMID 28887568, Free PMC Article
    3. The Vacuolar Manganese Transporter MTP8 Determines Tolerance to Iron Deficiency-Induced Chlorosis in Arabidopsis. Eroglu S, et al. Plant Physiol, 2016 Feb. PMID 26668333, Free PMC Article
    4. Metal Tolerance Protein 8 Mediates Manganese Homeostasis and Iron Reallocation during Seed Development and Germination. Eroglu S, et al. Plant Physiol, 2017 Jul. PMID 28461400, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tonoplast-associated calcium signaling regulates manganese homeostasis in Arabidopsis.
      Title: Tonoplast-associated calcium signaling regulates manganese homeostasis in Arabidopsis.
    2. Here the authors show that only mtp8-2 has an altered manganese distribution pattern in seeds. They also show that MTP8 can transport iron and is responsible for localization of iron to the same cells that store manganese.
      Title: The Arabidopsis MTP8 transporter determines the localization of manganese and iron in seeds.
    3. Results indicate that cell type-specific accumulation of Manganese and Iron in seeds depends on MTP8 and that this transporter plays an important role in the generation of seed metal stores as well as for metal homeostasis and germination efficiency under challenging environmental conditions. [MTP8]
      Title: Metal Tolerance Protein 8 Mediates Manganese Homeostasis and Iron Reallocation during Seed Development and Germination.
    4. METAL TOLERANCE PROTEIN8 (MTP8), a member of the Cation Diffusion Facilitator family, is a critical determinant for the tolerance to Fe deficiency-induced chlorosis.[MTP8]
      Title: The Vacuolar Manganese Transporter MTP8 Determines Tolerance to Iron Deficiency-Induced Chlorosis in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables manganese ion transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within iron ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within manganese ion transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within seed development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in root hair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cation efflux family protein
    NP_001319789.1
    • Cation efflux family protein; FUNCTIONS IN: cation transmembrane transporter activity, efflux transmembrane transporter activity; INVOLVED IN: cation transport, transmembrane transport; LOCATED IN: membrane; EXPRESSED IN: 6 plant structures; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Cation efflux protein (InterPro:IPR002524); BEST Arabidopsis thaliana protein match is: Cation efflux family protein (TAIR:AT1G79520.2); Has 4333 Blast hits to 4329 proteins in 1671 species: Archae - 143; Bacteria - 3530; Metazoa - 46; Fungi - 247; Plants - 204; Viruses - 0; Other Eukaryotes - 163 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21497633..21499943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339906.1 → NP_001319789.1  Cation efflux family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M2P2
      UniProtKB/TrEMBL
      A0A178VEZ3, A0A5S9XLU3, A0A654FIT7
      Conserved Domains (1) summary
      cl30791
      Location:123 → 402
      FieF; Divalent metal cation (Fe/Co/Zn/Cd) transporter [Inorganic ion transport and metabolism]

    2. NM_115668.3 → NP_191365.2  Cation efflux family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191365.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M2P2
      UniProtKB/TrEMBL
      A0A178VEZ3, A0A5S9XLU3, A0A654FIT7
      Conserved Domains (1) summary
      cl30791
      Location:123 → 402
      FieF; Divalent metal cation (Fe/Co/Zn/Cd) transporter [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M2P2.2

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