MRH2 Armadillo/beta-catenin repeat family protein / kinesin motor family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MRH2
Official Full Name: Armadillo/beta-catenin repeat family protein / kinesin motor family protein
Primary source: TAIR:AT3G54870
Locus tag: AT3G54870
See related: Araport:AT3G54870
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: Arabidopsis thaliana KINESIN Ungrouped clade; ARK1; ARMADILLO REPEAT-CONTAINING KINESIN 1; AtKINUc; CA-ROP2 ENHANCER 1; CAE1; gene A; MORPHOGENESIS OF ROOT HAIR 2
Summary: Armadillo-repeat containing kinesin-related protein. Plays a role during transition to root-hair tip growth.Mutants have short, branched root hairs and an excess of endoplasmic microtubles. Phenotype suggests ARK1 plays a role in modulating microtubule depolymerization during root hair tip growth.
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Genomic context

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See MRH2 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 21

Sequence:: Chromosome: 3; NC_003074.8 (20330680..20336866)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Armadillo-repeat kinesin1 interacts with Arabidopsis atlastin RHD3 to move ER with plus-end of microtubules.
Title: Armadillo-repeat kinesin1 interacts with Arabidopsis atlastin RHD3 to move ER with plus-end of microtubules.
ARK1 and NEK6 function independently in microtubule dynamics and cell morphogenesis.ARK1 does not require its ARM domain to induce microtubule catastrophe.
Title: The ARM Domain of ARMADILLO-REPEAT KINESIN 1 is Not Required for Microtubule Catastrophe But Can Negatively Regulate NIMA-RELATED KINASE 6 in Arabidopsis thaliana.
ARK1 is associated with microtubule catastrophe in Arabidopsis.
Title: The microtubule plus-end tracking protein ARMADILLO-REPEAT KINESIN1 promotes microtubule catastrophe in Arabidopsis.
The causative single nucleotide polymorphism changing a splicing site in ARMADILLO REPEAT-CONTAINING KINESIN1.
Title: Rapid identification of a natural knockout allele of ARMADILLO REPEAT-CONTAINING KINESIN1 that causes root hair branching by mapping-by-sequencing.
ARK1 is a component of a signaling pathway that affects cytoskeletal organization to specify growth orientation in Arabidopsis root hairs.
Title: A class I ADP-ribosylation factor GTPase-activating protein is critical for maintaining directional root hair growth in Arabidopsis.
the plant-specific kinesin-related protein MRH2 is an important component that controls MT organization and is likely involved in the ROP2 GTPase-controlled coordination of AF and MT during polarized growth of root hairs
Title: A mutation in MRH2 kinesin enhances the root hair tip growth defect caused by constitutively activated ROP2 small GTPase in Arabidopsis.

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General gene information

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Homology

Orthologs from OrthoDB

NM_115344.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of microtubule polymerization or depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root hair cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root hair cell tip growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Armadillo/beta-catenin repeat family protein / kinesin motor family protein

NP_191047.3

MORPHOGENESIS OF ROOT HAIR 2 (MRH2); FUNCTIONS IN: microtubule binding, actin binding, microtubule motor activity; INVOLVED IN: root hair cell tip growth, root hair cell differentiation, regulation of microtubule polymerization or depolymerization; LOCATED IN: chloroplast; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: armadillo repeat kinesin 3 (TAIR:AT1G12430.1); Has 140801 Blast hits to 75642 proteins in 3085 species: Archae - 1274; Bacteria - 19600; Metazoa - 61665; Fungi - 11208; Plants - 7696; Viruses - 409; Other Eukaryotes - 38949 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

20330680..20336866

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001339702.1 → NP_001326426.1 Armadillo/beta-catenin repeat family protein / kinesin motor family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

A9CP38, F4JE41, Q9SV36

UniProtKB/TrEMBL

A0A178V659, A0A178V7N7, A0A5S9XKV4

Conserved Domains (4) summary

COG1196
Location:472 → 757

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4372
Location:647 → 869

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

cd00106
Location:121 → 439

KISc; Kinesin motor domain

sd00043
Location:804 → 829

ARM; armadillo repeat [structural motif]
NM_001339703.1 → NP_001326427.1 Armadillo/beta-catenin repeat family protein / kinesin motor family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V7N7, A0A1I9LP88
NM_115344.4 → NP_191047.3 Armadillo/beta-catenin repeat family protein / kinesin motor family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_191047.3

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V7N7

Conserved Domains (7) summary

cd00020
Location:798 → 914

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

cd00106
Location:121 → 439

KISc; Kinesin motor domain

pfam00225
Location:115 → 441

Kinesin; Kinesin motor domain

pfam07106
Location:671 → 747

TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

pfam17045
Location:436 → 752

CEP63; Centrosomal protein of 63 kDa

sd00043
Location:804 → 829

ARM; armadillo repeat [structural motif]

cl12013
Location:493 → 660

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature