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    HSP93-III Clp ATPase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824048, updated on 15-Feb-2024

    Summary

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    Gene symbol
    HSP93-III
    Gene description
    Clp ATPase
    Primary source
    Araport:AT3G48870
    Locus tag
    AT3G48870
    See related
    TAIR:AT3G48870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCLPC; ATHSP93-III; ClpC2
    Summary
    Encodes a nuclear encoded protein with similarity to Clpa regulatory subunit of CLP protease complex. The protein is localized to the chloroplast stroma. May function redundantly with TIC complex in chloroplast protein import.
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    Genomic context

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    See HSP93-III in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (18122118..18126742, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene phosphate transporter 3;2 Neighboring gene coiled-coil protein Neighboring gene RNI-like superfamily protein Neighboring gene membrane-associated progesterone binding protein 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Gatekeeper Residue of ClpS1 from Arabidopsis thaliana Chloroplasts Determines its Affinity Towards Substrates of the Bacterial N-End Rule. Colombo CV, et al. Plant Cell Physiol, 2018 Mar 1. PMID 29401302
    2. Chloroplastic Hsp100 chaperones ClpC2 and ClpD interact in vitro with a transit peptide only when it is located at the N-terminus of a protein. Bruch EM, et al. BMC Plant Biol, 2012 Apr 30. PMID 22545953, Free PMC Article
    3. The amino-terminal domain of chloroplast Hsp93 is important for its membrane association and functions in vivo. Chu CC, et al. Plant Physiol, 2012 Apr. PMID 22353577, Free PMC Article
    4. Insights into the Clp/HSP100 chaperone system from chloroplasts of Arabidopsis thaliana. Rosano GL, et al. J Biol Chem, 2011 Aug 26. PMID 21737456, Free PMC Article
    5. Identification of clp genes expressed in senescing Arabidopsis leaves. Nakabayashi K, et al. Plant Cell Physiol, 1999 May. PMID 10427773

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtClpS1 allows for high-affinity binding to classical N-degrons of the bacterial N-end rule.
      Title: A Gatekeeper Residue of ClpS1 from Arabidopsis thaliana Chloroplasts Determines its Affinity Towards Substrates of the Bacterial N-End Rule.
    2. the proteolytic activity of Clp protease counteracts GBP binding to assure the appropriate content of GluTR and the adequate amino levulinic acid synthesis for chlorophyll and heme in higher plants.
      Title: Posttranslational Control of ALA Synthesis Includes GluTR Degradation by Clp Protease and Stabilization by GluTR-Binding Protein.
    3. Both AtClpC2 and AtClpD interacted with the transit peptides when they were located at the N-terminal position of a protein, but not when they were allocated to the C-terminal end or at the interior of a polypeptide. [ClpC2]
      Title: Chloroplastic Hsp100 chaperones ClpC2 and ClpD interact in vitro with a transit peptide only when it is located at the N-terminus of a protein.
    4. The association of Hsp93 with the inner envelope membrane through its amino-terminal domain is important for the functions of Hsp93 in vivo.[Hsp93]
      Title: The amino-terminal domain of chloroplast Hsp93 is important for its membrane association and functions in vivo.
    5. Data show that ClpS1 (AT1G68660) interacts with plastid ClpC1 (AT5G50920), ClpC2 (AT3G48870), but not with ClpT1 (AT4G25370) or ClpT2 (AT4G12060).
      Title: ClpS1 is a conserved substrate selector for the chloroplast Clp protease system in Arabidopsis.
    6. The interaction of Tic110, Tic40 and Hsp93 in A. thaliana chloroplast protein transport is described. [Hsp93]
      Title: In vivo studies on the roles of Tic110, Tic40 and Hsp93 during chloroplast protein import.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203106.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within protein import into chloroplast stroma ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plastid HDA PubMed 
    located_in plastid stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Clp ATPase
    NP_001190035.1
    • HSP93-III; FUNCTIONS IN: in 6 functions; INVOLVED IN: protein import into chloroplast stroma, chloroplast organization; LOCATED IN: mitochondrion, chloroplast, chloroplast stroma, Tic complex; EXPRESSED IN: guard cell; EXPRESSED DURING: seed development stages; CONTAINS InterPro DOMAIN/s: Clp ATPase, C-terminal (InterPro:IPR019489), ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA-2 (InterPro:IPR013093), ATPase, AAA+ type, core (InterPro:IPR003593), Chaperonin clpA/B (InterPro:IPR001270), Chaperonin ClpA/B, conserved site (InterPro:IPR018368), Clp, N-terminal (InterPro:IPR004176), UvrB/UvrC protein (InterPro:IPR001943); BEST Arabidopsis thaliana protein match is: CLPC homologue 1 (TAIR:AT5G50920.1).
    NP_566912.2
    • HSP93-III; FUNCTIONS IN: in 6 functions; INVOLVED IN: protein import into chloroplast stroma, chloroplast organization; LOCATED IN: in 7 components; EXPRESSED IN: guard cell, leaf; EXPRESSED DURING: seed development stages; CONTAINS InterPro DOMAIN/s: Clp ATPase, C-terminal (InterPro:IPR019489), ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA-2 (InterPro:IPR013093), ATPase, AAA+ type, core (InterPro:IPR003593), Chaperonin clpA/B (InterPro:IPR001270), Chaperonin ClpA/B, conserved site (InterPro:IPR018368), UvrB/UvrC protein (InterPro:IPR001943), Clp, N-terminal (InterPro:IPR004176); BEST Arabidopsis thaliana protein match is: CLPC homologue 1 (TAIR:AT5G50920.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      18122118..18126742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339385.1 → NP_001325472.1  Clp ATPase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LLC3, Q93ZM4, Q9M2Z6, Q9SXJ7
      UniProtKB/TrEMBL
      A0A178VA06, A0A5S9XJ62, A0A654FG01
      Conserved Domains (1) summary
      CHL00095
      Location:114 → 929
      clpC; Clp protease ATP binding subunit

    2. NM_114746.5 → NP_566912.2  Clp ATPase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566912.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LLC3, Q93ZM4, Q9M2Z6, Q9SXJ7
      UniProtKB/TrEMBL
      A0A178VA06, A0A5S9XJ62, A0A654FG01
      Conserved Domains (1) summary
      CHL00095
      Location:114 → 929
      clpC; Clp protease ATP binding subunit

    3. NM_001339386.1 → NP_001325473.1  Clp ATPase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LLC3, Q93ZM4, Q9M2Z6, Q9SXJ7
      UniProtKB/TrEMBL
      A0A178VA06, A0A5S9XJ62, A0A654FG01
      Conserved Domains (1) summary
      CHL00095
      Location:114 → 929
      clpC; Clp protease ATP binding subunit

    4. NM_001203106.2 → NP_001190035.1  Clp ATPase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190035.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EVS6, F4JF64
      Conserved Domains (6) summary
      cd00009
      Location:267 → 419
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      CHL00095
      Location:83 → 898
      clpC; Clp protease ATP binding subunit
      pfam02151
      Location:501 → 536
      UVR; UvrB/uvrC motif
      pfam02861
      Location:98 → 150
      Clp_N; Clp amino terminal domain, pathogenicity island component
      pfam07724
      Location:628 → 800
      AAA_2; AAA domain (Cdc48 subfamily)
      pfam10431
      Location:807 → 887
      ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SXJ7.1

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