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    GRIK1 geminivirus rep interacting kinase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823660, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GRIK1
    Official Full Name
    geminivirus rep interacting kinase 1
    Primary source
    TAIR:AT3G45240
    Locus tag
    AT3G45240
    See related
    Araport:AT3G45240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSNAK2; F18N11.1; geminivirus rep interacting kinase 1
    Summary
    Encodes a geminivirus Rep interacting kinase (GRIK; GRIK1/AT3G45240, GRIK2/AT5G60550). GRIKs are SnRK1 (SNF1-related kinases) activating kinases. Both GRIKs specifically bind to the SnRK1 catalytic subunit and phosphorylate the equivalent threonine residue in its activation loop in vitro.
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    Genomic context

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    See GRIK1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Sequence:
    Chromosome: 3; NC_003074.8 (16570478..16573762, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Serine protease inhibitor (SERPIN) family protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene ECA1 gametogenesis related family protein Neighboring gene ECA1 gametogenesis related family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A geminivirus replication protein interacts with a protein kinase and a motor protein that display different expression patterns during plant development and infection. Kong LJ, et al. Plant Cell, 2002 Aug. PMID 12172024, Free PMC Article
    2. Cross-phosphorylation between Arabidopsis thaliana sucrose nonfermenting 1-related protein kinase 1 (AtSnRK1) and its activating kinase (AtSnAK) determines their catalytic activities. Crozet P, et al. J Biol Chem, 2010 Apr 16. PMID 20164192, Free PMC Article
    3. AKIN10, a representative Arabidopsis SNF1-related protein kinase 1 (SnRK1), phosphorylates and downregulates plant HMG-CoA reductase. Robertlee J, et al. FEBS Lett, 2017 Apr. PMID 28263378
    4. Arabidopsis protein kinases GRIK1 and GRIK2 specifically activate SnRK1 by phosphorylating its activation loop. Shen W, et al. Plant Physiol, 2009 Jun. PMID 19339507, Free PMC Article
    5. Geminivirus infection up-regulates the expression of two Arabidopsis protein kinases related to yeast SNF1- and mammalian AMPK-activating kinases. Shen W, et al. Plant Physiol, 2006 Dec. PMID 17041027, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that AKIN10 phosphorylates and inactivates HMGR; AKIN10 phosphorylates not only conserved Ser577 in active site but also other site/sites in noncatalytic domain of HMGR; inactivation of HMGR by AKIN10 requires interaction of AKIN10 with GRIK1. (AKIN10 = SnRK1 protein kinase; HMGR = hydroxymethylglutaryl-CoA-reductase; GRIK1 = geminivirus Rep-interacting kinase 1)
      Title: AKIN10, a representative Arabidopsis SNF1-related protein kinase 1 (SnRK1), phosphorylates and downregulates plant HMG-CoA reductase.
    2. GRIKs are SnRK1 activating kinases.
      Title: Arabidopsis protein kinases GRIK1 and GRIK2 specifically activate SnRK1 by phosphorylating its activation loop.
    3. Geminivirus Rep-interacting kinase 1, GRIK1 and GRIK2, interact with the geminivirus replication protein AL1 function by mediating one or more processes during early plant development and geminivirus infection by activating SNF1-related kinases. [GRIK1]
      Title: Geminivirus infection up-regulates the expression of two Arabidopsis protein kinases related to yeast SNF1- and mammalian AMPK-activating kinases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Miscellaneous features

    • Loc: c16573166-16573089 AT3G45240.uORF1
    NM_001203084.1
    NM_114393.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to virus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    geminivirus rep interacting kinase 1
    NP_001030811.1
    • geminivirus rep interacting kinase 1 (GRIK1); CONTAINS InterPro DOMAIN/s: Calcium/calmodulin-dependent protein kinase kinase (InterPro:IPR020657), Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: geminivirus rep interacting kinase 2 (TAIR:AT5G60550.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001190013.1
    • geminivirus rep interacting kinase 1 (GRIK1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Calcium/calmodulin-dependent protein kinase kinase (InterPro:IPR020657), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: geminivirus rep interacting kinase 2 (TAIR:AT5G60550.1).
    NP_566876.3
    • geminivirus rep interacting kinase 1 (GRIK1); CONTAINS InterPro DOMAIN/s: Calcium/calmodulin-dependent protein kinase kinase (InterPro:IPR020657), Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: geminivirus rep interacting kinase 2 (TAIR:AT5G60550.1); Has 117743 Blast hits to 115793 proteins in 4740 species: Archae - 114; Bacteria - 14389; Metazoa - 44129; Fungi - 12221; Plants - 26959; Viruses - 496; Other Eukaryotes - 19435 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      16570478..16573762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001035734.2 → NP_001030811.1  geminivirus rep interacting kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030811.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93V58, Q9M1T5
      UniProtKB/TrEMBL
      A0A178VP91, A0A5S9XIT7
      Conserved Domains (2) summary
      smart00220
      Location:108 → 369
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14008
      Location:114 → 369
      STKc_LKB1_CaMKK; Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins

    2. NM_114393.4 → NP_566876.3  geminivirus rep interacting kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566876.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93V58, Q9M1T5
      UniProtKB/TrEMBL
      A0A178VP91, A0A5S9XIT7
      Conserved Domains (2) summary
      smart00220
      Location:108 → 369
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14008
      Location:114 → 369
      STKc_LKB1_CaMKK; Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins

    3. NM_001203084.1 → NP_001190013.1  geminivirus rep interacting kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190013.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VP91, A0A5S9XIT7, F4J5I5
      Conserved Domains (2) summary
      smart00220
      Location:108 → 366
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14008
      Location:114 → 366
      STKc_LKB1_CaMKK; Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93V58.1

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