BUB3.1 Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BUB3.1
Official Full Name: Transducin/WD40 repeat-like superfamily protein
Primary source: TAIR:AT3G19590
Locus tag: AT3G19590
See related: Araport:AT3G19590
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BUB (BUDDING UNINHIBITED BY BENZYMIDAZOL) 3.1; BUB (BUDDING UNINHIBITED BY BENZYMIDAZOL) 3.1
Summary: Encodes a protein that may have a role in the spindle assembly checkpoint.
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Genomic context

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See BUB3.1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 9

Sequence:: Chromosome: 3; NC_003074.8 (6805622..6808593)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

role in phragmoplast microtubule reorganization during cytokinesis
Title: Role of the BUB3 protein in phragmoplast microtubule reorganization during cytokinesis.
In Arabidosis, there is high similarity of Bub3.1 and Bub3.2 sequences at the nucleotide level but Bub3.1 and not Bub3.2 showed increased expression during mitosis. Bub3.1 appeared to be essential during embryogenesis. [Bub3.1]
Title: The Arabidopsis checkpoint protein Bub3.1 is essential for gametophyte development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_112849.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in phragmoplast	IDA Inferred from Direct Assay more info	PubMed
located_in spindle microtubule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Transducin/WD40 repeat-like superfamily protein

NP_566644.1

BUB (BUDDING UNINHIBITED BY BENZYMIDAZOL) 3.1 (BUB3.1); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781), G-protein beta WD-40 repeat, region (InterPro:IPR020472); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT1G49910.1); Has 7284 Blast hits to 5351 proteins in 449 species: Archae - 14; Bacteria - 1710; Metazoa - 2206; Fungi - 1743; Plants - 568; Viruses - 0; Other Eukaryotes - 1043 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

6805622..6808593

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_112849.5 → NP_566644.1 Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566644.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LJN8

UniProtKB/TrEMBL

A0A178VA46, A0A5S9XDQ3

Conserved Domains (2) summary

sd00039
Location:20 → 56

7WD40; WD40 repeat [structural motif]

cl29593
Location:17 → 303

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...