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    LOG2 RING/U-box superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820135, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LOG2
    Official Full Name
    RING/U-box superfamily protein
    Primary source
    TAIR:AT3G09770
    Locus tag
    AT3G09770
    See related
    Araport:AT3G09770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ABA insensitive RING protein 3; AIRP3; AtAIRP3; F11F8.36; LOSS OF GDU 2
    Summary
    Encodes a ubiquitin E3 ligase LOG2 (LOSS OF GDU2). Required for GLUTAMINE DUMPER1(GDU1)-induced amino secretion.
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    Genomic context

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    See LOG2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (2996179..2998255, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene syntaxin of plants 71 Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene RING/U-box superfamily protein Neighboring gene CRINKLY4 related 1 Neighboring gene ubiquitin 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of Amino Acid Homeostasis by a Ubiquitin Ligase-Coactivator Protein Complex. Guerra D, et al. J Biol Chem, 2017 Mar 3. PMID 28100770, Free PMC Article
    2. The Arabidopsis RING E3 ubiquitin ligase AtAIRP3/LOG2 participates in positive regulation of high-salt and drought stress responses. Kim JH, et al. Plant Physiol, 2013 Jul. PMID 23696092, Free PMC Article
    3. Functional conservation between mammalian MGRN1 and plant LOG2 ubiquitin ligases. Guerra DD, et al. FEBS Lett, 2013 Nov 1. PMID 24036454, Free PMC Article
    4. The ubiquitin E3 ligase LOSS OF GDU2 is required for GLUTAMINE DUMPER1-induced amino acid secretion in Arabidopsis. Pratelli R, et al. Plant Physiol, 2012 Apr. PMID 22291198, Free PMC Article
    5. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GDU1 activates LOG2 to stimulate amino acid export, a process that could be negatively regulated by GDU1 ubiquitination and LOG2 self-ubiquitination.
      Title: Control of Amino Acid Homeostasis by a Ubiquitin Ligase-Coactivator Protein Complex.
    2. LOG2 plays dual functions in drought stress response and amino acid transport in Arabidopsis.LOG2 participates in positive regulation of high-salt stress response.
      Title: The Arabidopsis RING E3 ubiquitin ligase AtAIRP3/LOG2 participates in positive regulation of high-salt and drought stress responses.
    3. Interaction of GDU1 and the ubiquitin ligase LOG2 plays a significant role in the regulation of amino acid export from plant cells.[LOG2]
      Title: The ubiquitin E3 ligase LOSS OF GDU2 is required for GLUTAMINE DUMPER1-induced amino acid secretion in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_111812.4
    NM_180216.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid-activated signaling pathway involved in stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in abscisic acid-activated signaling pathway involved in stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular amino acid homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular amino acid homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RING/U-box superfamily protein
    NP_566356.1
    • RING/U-box superfamily protein; FUNCTIONS IN: zinc ion binding; INVOLVED IN: N-terminal protein myristoylation; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT5G03200.1); Has 9681 Blast hits to 6810 proteins in 512 species: Archae - 8; Bacteria - 442; Metazoa - 3215; Fungi - 970; Plants - 3369; Viruses - 475; Other Eukaryotes - 1202 (source: NCBI BLink).
    NP_850547.1
    • RING/U-box superfamily protein; FUNCTIONS IN: zinc ion binding; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT5G03200.1); Has 7619 Blast hits to 4715 proteins in 450 species: Archae - 8; Bacteria - 442; Metazoa - 2165; Fungi - 884; Plants - 2938; Viruses - 368; Other Eukaryotes - 814 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2996179..2998255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111812.4 → NP_566356.1  RING/U-box superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566356.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9S752
      UniProtKB/TrEMBL
      A0A178VJI4, A0A5S9XAI9
      Conserved Domains (1) summary
      cd16789
      Location:318 → 358
      mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins

    2. NM_180216.1 → NP_850547.1  RING/U-box superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850547.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4J1B3
      Conserved Domains (1) summary
      pfam13920
      Location:317 → 338
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S752.1

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