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    PVA12 plant VAP homolog 12 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819122, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PVA12
    Official Full Name
    plant VAP homolog 12
    Primary source
    TAIR:AT2G45140
    Locus tag
    AT2G45140
    See related
    Araport:AT2G45140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    plant VAP homolog 12; T14P1.5
    Summary
    Encodes a Plant VAMP-Associated protein that localizes to the ER and binds to the sitosterol-binding protein ORP3a. The WFDE motif in ORP3a appears to be important for this direct interaction. Mutation of this motif causes ORP3a to relocalize to the Golgi and cytosol. The interaction between PVA12 and ORP3a does not appear to be sterol-dependent.
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    Genomic context

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    See PVA12 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (18610806..18613302)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene SPX domain protein 3 Neighboring gene RING/U-box superfamily protein Neighboring gene cytidinediphosphate diacylglycerol synthase 4 Neighboring gene GRAS family transcription factor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plant Endocytosis Requires the ER Membrane-Anchored Proteins VAP27-1 and VAP27-3. Stefano G, et al. Cell Rep, 2018 May 22. PMID 29791842
    2. The targeting of the oxysterol-binding protein ORP3a to the endoplasmic reticulum relies on the plant VAP33 homolog PVA12. Saravanan RS, et al. Plant J, 2009 Jun. PMID 19207211
    3. The DC1-domain protein VACUOLELESS GAMETOPHYTES is essential for development of female and male gametophytes in Arabidopsis. D'Ippólito S, et al. Plant J, 2017 Apr. PMID 28107777
    4. Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry. Nühse TS, et al. Mol Cell Proteomics, 2003 Nov. PMID 14506206
    5. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001337116.1
    NM_130077.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein targeting IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    plant VAP homolog 12
    NP_182039.1
    • plant VAP homolog 12 (PVA12); FUNCTIONS IN: structural molecule activity; LOCATED IN: cytosol, endoplasmic reticulum, nucleus, plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: PapD-like (InterPro:IPR008962), Major sperm protein (InterPro:IPR000535), Vesicle-associated membrane protein (InterPro:IPR016763); BEST Arabidopsis thaliana protein match is: vesicle associated protein (TAIR:AT3G60600.1); Has 1106 Blast hits to 1079 proteins in 208 species: Archae - 0; Bacteria - 0; Metazoa - 441; Fungi - 140; Plants - 434; Viruses - 0; Other Eukaryotes - 91 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18610806..18613302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130077.3 → NP_182039.1  plant VAP homolog 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182039.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SHC8
      UniProtKB/TrEMBL
      A0A178W0Q8, A0A5S9X7M3
      Conserved Domains (1) summary
      pfam00635
      Location:5 → 112
      Motile_Sperm; MSP (Major sperm protein) domain

    2. NM_001337116.1 → NP_001324913.1  plant VAP homolog 12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B1Q1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SHC8.1

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