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    FRA8 Exostosin family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817357, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FRA8
    Official Full Name
    Exostosin family protein
    Primary source
    TAIR:AT2G28110
    Locus tag
    AT2G28110
    See related
    Araport:AT2G28110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F24D13.10; F24D13_10; FRAGILE FIBER 8; IRREGULAR XYLEM 7; IRX7
    Summary
    Homolog to AT5G22940, a member of glycosyltransferase family 47 that is involved in secondary cell wall biosynthesis. It exhibits high sequence similarity to tobacco (Nicotiana plumbaginifolia) pectin glucuronyltransferase. Protein has a domain that shares significant similarity with the pfam03016 domain. It is expressed specifically in developing vessels and fiber cells, and FRA8 is targeted to Golgi. Mutants have irregular xylem formation, reduced cellulose levels and plants are smaller than normal siblings.
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    Genomic context

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    See FRA8 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (11977865..11980003, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene ncRNA Neighboring gene alpha-L-fucosidase 1 Neighboring gene replication factor-A carboxy-terminal domain protein Neighboring gene Major facilitator superfamily protein Neighboring gene actin protein 2/3 complex subunit-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Irregular xylem 7 (IRX7) is required for anchoring seed coat mucilage in Arabidopsis. Hu R, et al. Plant Mol Biol, 2016 Sep. PMID 27333892
    2. Arabidopsis fragile fiber8, which encodes a putative glucuronyltransferase, is essential for normal secondary wall synthesis. Zhong R, et al. Plant Cell, 2005 Dec. PMID 16272433, Free PMC Article
    3. The Arabidopsis irregular xylem8 mutant is deficient in glucuronoxylan and homogalacturonan, which are essential for secondary cell wall integrity. Persson S, et al. Plant Cell, 2007 Jan. PMID 17237350, Free PMC Article
    4. Comparison of five xylan synthesis mutants reveals new insight into the mechanisms of xylan synthesis. Brown DM, et al. Plant J, 2007 Dec. PMID 17944810
    5. Identification of novel genes in Arabidopsis involved in secondary cell wall formation using expression profiling and reverse genetics. Brown DM, et al. Plant Cell, 2005 Aug. PMID 15980264, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_179782.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glucuronosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucuronoxylan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glucuronoxylan biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type secondary cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Exostosin family protein
    NP_850113.2
    • FRAGILE FIBER 8 (FRA8); CONTAINS InterPro DOMAIN/s: Exostosin-like (InterPro:IPR004263); BEST Arabidopsis thaliana protein match is: FRA8 homolog (TAIR:AT5G22940.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11977865..11980003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179782.4 → NP_850113.2  Exostosin family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850113.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RXC5, Q9ZUV3
      UniProtKB/TrEMBL
      A0A5S9X221, W8Q712
      Conserved Domains (1) summary
      pfam03016
      Location:94 → 391
      Exostosin; Exostosin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZUV3.1

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