U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    COV1 CONTINUOUS VASCULAR RING protein (DUF502) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816531, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    COV1
    Official Full Name
    CONTINUOUS VASCULAR RING protein (DUF502)
    Primary source
    TAIR:AT2G20120
    Locus tag
    AT2G20120
    See related
    Araport:AT2G20120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CONTINUOUS VASCULAR RING; T2G17.8; T2G17_8
    Summary
    Encodes an integral membrane protein of unknown function, highly conserved between plants and bacteria; is likely to be involved in a mechanism that negatively regulates the differentiation of vascular tissue in the stem. Mutants display a dramatic increase in vascular tissue development in the stem in place of the interfascicular region that normally separates the vascular bundles.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See COV1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (8687330..8690214, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene Tesmin/TSO1-like CXC domain-containing protein Neighboring gene uncharacterized protein Neighboring gene AAA-type ATPase family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. CONTINUOUS VASCULAR RING (COV1) is a trans-Golgi network-localized membrane protein required for Golgi morphology and vacuolar protein sorting. Shirakawa M, et al. Plant Cell Physiol, 2014 Apr. PMID 24363287
    2. Isolation of COV1, a gene involved in the regulation of vascular patterning in the stem of Arabidopsis. Parker G, et al. Development, 2003 May. PMID 12668628
    3. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Parsons HT, et al. Plant Physiol, 2012 May. PMID 22430844, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the novel tans Golgi network-localized protein COV1 is required for Golgi morphology, vacuolar trafficking and myrosin cell development.
      Title: CONTINUOUS VASCULAR RING (COV1) is a trans-Golgi network-localized membrane protein required for Golgi morphology and vacuolar protein sorting.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    NM_001335662.1
    NM_127570.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in auxin-activated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within stem vascular tissue pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    CONTINUOUS VASCULAR RING protein (DUF502)
    NP_565464.2
    • CONTINUOUS VASCULAR RING (COV1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: stem vascular tissue pattern formation; LOCATED IN: integral to membrane; EXPRESSED IN: stem, root, flower, leaf; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF502 (InterPro:IPR007462); BEST Arabidopsis thaliana protein match is: like COV 1 (TAIR:AT2G20130.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      8687330..8690214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127570.5 → NP_565464.2  CONTINUOUS VASCULAR RING protein (DUF502) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565464.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8AZ44, F4IUE7, Q0WL91, Q94EH1, Q9SL69
      UniProtKB/TrEMBL
      A0A178VYU8, A0A5S9WZG8
      Conserved Domains (1) summary
      pfam04367
      Location:112 → 213
      DUF502; Protein of unknown function (DUF502)

    2. NM_001335662.1 → NP_001324133.1  CONTINUOUS VASCULAR RING protein (DUF502) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8AZ44, F4IUE7, Q0WL91, Q94EH1, Q9SL69
      UniProtKB/TrEMBL
      A0A178VYU8, A0A5S9WZG8
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools