Kcna5 potassium voltage-gated channel subfamily A member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcna5provided by RGD
Official Full Name: potassium voltage-gated channel subfamily A member 5provided by RGD
Primary source: RGD:2953
See related: Ensembl:ENSRNOG00000019719 AllianceGenome:RGD:2953
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kv1; Kv1.5
Summary: Enables delayed rectifier potassium channel activity; outward rectifier potassium channel activity; and signaling receptor binding activity. Involved in several processes, including metal ion homeostasis; positive regulation of G1/S transition of mitotic cell cycle; and potassium ion export across plasma membrane. Located in several cellular components, including Z disc; intercalated disc; and intracellular canaliculus. Is integral component of plasma membrane. Part of voltage-gated potassium channel complex. Used to study pulmonary hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in familial atrial fibrillation and pulmonary hypertension. Orthologous to human KCNA5 (potassium voltage-gated channel subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (161040853..161044311, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (159354689..159358173, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (159077195..159079003, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression of Kv1.5 and 4-aminopyridine (Kv channel special inhibitor)-sensitive Kv current were correlated with the inhibition of miR-206 in PA rings of IUGR - CH rats and cultured IUGR PASMC s exposed to hypoxia. Thus, miR-206 may be a trigger for induction of exaggerated CH-pulmonary artery hypertension of IUGR via Kv1.5.
Title: Increased Expression of MicroRNA-206 Inhibits Potassium Voltage-Gated Channel Subfamily A Member 5 in Pulmonary Arterial Smooth Muscle Cells and Is Related to Exaggerated Pulmonary Artery Hypertension Following Intrauterine Growth Retardation in Rats.
Ang II selectively stimulates degradation of KV1.5 channels to reduce functional KV1.5 channel surface abundance in mesenteric artery myocytes
Title: Angiotensin II reduces the surface abundance of K(V) 1.5 channels in arterial myocytes to stimulate vasoconstriction.
Ang II upregulates the expression of Kv1.5, SAP97 and TGF-beta1 in neonatal rat atrial myocytes.
Title: Angiotensin II upregulates Kv1.5 expression through ROS-dependent transforming growth factor-beta1 and extracellular signal-regulated kinase 1/2 signalings in neonatal rat atrial myocytes.
AMPK selectively inhibits Kv1.5 in pulmonary arterial myocytes
Title: AMP-activated protein kinase inhibits Kv 1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation.
This study demonstrates for the first time an altered gene and protein expression of NFATc2 and KV1.5 in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia. Upregulation of NFATc2 with concomitant downregulation of KV1.5 channels may contribute to abnormal vascular remodeling.
Title: Imbalance of NFATc2 and KV1.5 Expression in Rat Pulmonary Vasculature of Nitrofen-Induced Congenital Diaphragmatic Hernia.
H2S downregulates Ang II-induced atrial Kv1.5 expression by attenuating Nox4-related ROS-triggered P-Smad2/3 and P-ERK 1/2 activation during atrial fibrillation
Title: H(2)S inhibits angiotensin II-induced atrial Kv1.5 upregulation by attenuating Nox4-mediated ROS generation during atrial fibrillation.
Data indicate that intravascular pressure-induced membrane depolarization selectively increased voltage-dependent potassium channels K(v)1.5 surface abundance to increase K(v) currents in arterial myocytes, which would limit vasoconstriction.
Title: Intravascular pressure enhances the abundance of functional Kv1.5 channels at the surface of arterial smooth muscle cells.
KV1.5, a DPO-1-sensitive KDR channel, plays a major role in determining microvascular tone and the response to vasoconstrictors and vasodilators.
Title: Diphenyl phosphine oxide-1-sensitive K(+) channels contribute to the vascular tone and reactivity of resistance arteries from brain and skeletal muscle.
Data suggest that exercise training reverses the pathological expression of the Kv1.2, Kv1.5, and BKCa channels in aortic myocytes from spontaneously hypertensive rats.
Title: Exercise training reverses alterations in Kv and BKCa channel molecular expression in thoracic aorta smooth muscle cells from spontaneously hypertensive rats.
The inhibited expression of Kv1.5 in pulmonary artery smooth muscle cells contribute to the development of exaggerated chronic hypoxia pulmonary hypertension in intrauterine growth retardation rats during adulthood.
Title: Decreased Kv1.5 expression in intrauterine growth retardation rats with exaggerated pulmonary hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Wox39 (e-PCR)
- UniSTS:518703

Kcna5 (e-PCR), detects polymorphism
- UniSTS:463210

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-actinin binding	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables delayed rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables outward rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables outward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated potassium channel activity involved in SA node cell action potential repolarization	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during SA node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during bundle of His cell action potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of myoblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion export across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in protein complex oligomerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of atrial cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in intercalated disc	IBA Inferred from Biological aspect of Ancestor more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in intracellular canaliculus	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily A member 5

Names: Potassium (K+) channel protein alpha 5; RCK7; RK4; potassium channel, voltage gated shaker related subfamily A, member 5; potassium voltage-gated channel, shaker-related subfamily, member 5; voltage-gated potassium channel subunit Kv1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012972.2 → NP_037104.1 potassium voltage-gated channel subfamily A member 5

See identical proteins and their annotated locations for NP_037104.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P19024, Q6LEB7

UniProtKB/TrEMBL

A6ILV3

Related

ENSRNOP00000026691.1, ENSRNOT00000026691.3

Conserved Domains (4) summary

smart00225
Location:113 → 207

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:305 → 515

Ion_trans; Ion transport protein

pfam02214
Location:113 → 204

BTB_2; BTB/POZ domain

pfam07885
Location:429 → 506

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

161040853..161044311 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107114.2 → XP_038963042.1 potassium voltage-gated channel subfamily A member 5 isoform X1

Conserved Domains (2) summary

cl38908
Location:1 → 37

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:40 → 315

Ion_trans; Ion transport protein