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    LIN52 lin-52 DREAM MuvB core complex component [ Homo sapiens (human) ]

    Gene ID: 91750, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LIN52provided by HGNC
    Official Full Name
    lin-52 DREAM MuvB core complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:19856
    See related
    Ensembl:ENSG00000205659 AllianceGenome:HGNC:19856
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C14orf46; c14_5549
    Summary
    Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be part of DRM complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See LIN52 in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (74084956..74201493)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (68292638..68409288)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74551659..74668196)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 (inactive) Neighboring gene Sharpr-MPRA regulatory region 8014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5926 Neighboring gene Sharpr-MPRA regulatory regions 4216 and 10298 Neighboring gene ribosomal protein L41 pseudogene 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36659 Neighboring gene basal body orientation factor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74530601-74530820 Neighboring gene aldehyde dehydrogenase 6 family member A1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8725 Neighboring gene uncharacterized LOC105370563 Neighboring gene RNY4 pseudogene 21 Neighboring gene RNA, 7SL, cytoplasmic 530, pseudogene Neighboring gene small ubiquitin-related modifier 2-like Neighboring gene MPRA-validated peak2199 silencer Neighboring gene uncharacterized LOC105370564 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:74707503-74708468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:74712311-74712812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5928 Neighboring gene visual system homeobox 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Tschöp K, et al. Genes Dev, 2011 Apr 15. PMID 21498571, Free PMC Article
    2. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Litovchick L, et al. Genes Dev, 2011 Apr 15. PMID 21498570, Free PMC Article
    3. The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb. Iness AN, et al. Oncogene, 2019 Feb. PMID 30206359, Free PMC Article
    4. Structural mechanisms of DREAM complex assembly and regulation. Guiley KZ, et al. Genes Dev, 2015 May 1. PMID 25917549, Free PMC Article
    5. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. Schmit F, et al. Cell Cycle, 2007 Aug 1. PMID 17671431

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Web-based, participant-driven studies yield novel genetic associations for common traits.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DRM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    protein lin-52 homolog
    Names
    lin-52 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024674.3 → NP_001019845.2  protein lin-52 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC006349, AK023979, BC094003
      Consensus CDS
      CCDS32120.2
      UniProtKB/TrEMBL
      B3KN83
      Related
      ENSP00000451812.2, ENST00000555028.7
      Conserved Domains (1) summary
      pfam10044
      Location:14 → 107
      LIN52; Retinal tissue protein

    2. NM_001372005.1 → NP_001358934.1  protein lin-52 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC005484
      Conserved Domains (1) summary
      pfam10044
      Location:14 → 94
      LIN52; Retinal tissue protein

    3. NM_001372006.1 → NP_001358935.1  protein lin-52 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC005484, AC006349
      Conserved Domains (1) summary
      pfam10044
      Location:12 → 105
      LIN52; Retinal tissue protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      74084956..74201493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021764.2 → XP_016877253.1  protein lin-52 homolog isoform X6

      Conserved Domains (1) summary
      pfam10044
      Location:18 → 98
      LIN52; Retinal tissue protein

    2. XM_047431916.1 → XP_047287872.1  protein lin-52 homolog isoform X1

    3. XM_011537321.4 → XP_011535623.2  protein lin-52 homolog isoform X2

    4. XM_047431917.1 → XP_047287873.1  protein lin-52 homolog isoform X3

    5. XM_011537322.3 → XP_011535624.2  protein lin-52 homolog isoform X4

    6. XM_047431918.1 → XP_047287874.1  protein lin-52 homolog isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      68292638..68409288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376977.1 → XP_054232952.1  protein lin-52 homolog isoform X6

    2. XM_054376972.1 → XP_054232947.1  protein lin-52 homolog isoform X1

    3. XM_054376973.1 → XP_054232948.1  protein lin-52 homolog isoform X2

    4. XM_054376974.1 → XP_054232949.1  protein lin-52 homolog isoform X3

    5. XM_054376975.1 → XP_054232950.1  protein lin-52 homolog isoform X4

    6. XM_054376976.1 → XP_054232951.1  protein lin-52 homolog isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q52LA3.1 GenPept UniProtKB/Swiss-Prot:Q52LA3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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