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    ZNF845 zinc finger protein 845 [ Homo sapiens (human) ]

    Gene ID: 91664, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF845provided by HGNC
    Official Full Name
    zinc finger protein 845provided by HGNC
    Primary source
    HGNC:HGNC:25112
    See related
    Ensembl:ENSG00000213799 AllianceGenome:HGNC:25112
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 2.2), thyroid (RPKM 2.2) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF845 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53333749..53356906)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56413246..56436414)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53837002..53860159)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987270 Neighboring gene family with sequence similarity 90 member A28, pseudogene Neighboring gene vomeronasal 1 receptor 6, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53836118-53836982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15065 Neighboring gene putative zinc finger protein 137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53872557-53873058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53873059-53873558 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:53877455-53878025 Neighboring gene zinc finger protein 525 Neighboring gene ZNF765-ZNF761 readthrough Neighboring gene ribosomal protein L39 pseudogene 35 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11009 Neighboring gene zinc finger protein 765 Neighboring gene putative zinc finger protein 137

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    2. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Siddaway R, et al. Mol Cell Proteomics, 2022 Oct. PMID 36089195, Free PMC Article
    3. The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers. Oravcová M, et al. Elife, 2022 Nov 14. PMID 36373674, Free PMC Article
    4. PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα. Ramberger E, et al. iScience, 2021 Jun 25. PMID 34189442, Free PMC Article
    5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 845

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321522.2 → NP_001308451.1  zinc finger protein 845

      Status: VALIDATED

      Source sequence(s)
      AC010467
      Consensus CDS
      CCDS46170.1
      UniProtKB/Swiss-Prot
      Q96IR2
      Conserved Domains (4) summary
      COG5048
      Location:381 → 813
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:693 → 713
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:873 → 898
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001321523.2 → NP_001308452.1  zinc finger protein 845

      Status: VALIDATED

      Source sequence(s)
      AC010467
      Consensus CDS
      CCDS46170.1
      UniProtKB/Swiss-Prot
      Q96IR2
      Conserved Domains (4) summary
      COG5048
      Location:381 → 813
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:693 → 713
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:873 → 898
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001321524.2 → NP_001308453.1  zinc finger protein 845

      Status: VALIDATED

      Source sequence(s)
      AC010467
      Consensus CDS
      CCDS46170.1
      UniProtKB/Swiss-Prot
      Q96IR2
      Related
      ENSP00000470005.1, ENST00000595091.6
      Conserved Domains (4) summary
      COG5048
      Location:381 → 813
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:693 → 713
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:873 → 898
      zf-H2C2_2; Zinc-finger double domain

    4. NM_138374.3 → NP_612383.1  zinc finger protein 845

      See identical proteins and their annotated locations for NP_612383.1

      Status: VALIDATED

      Source sequence(s)
      AC010467, DC400704
      Consensus CDS
      CCDS46170.1
      UniProtKB/Swiss-Prot
      Q96IR2
      Related
      ENSP00000388311.1, ENST00000458035.3
      Conserved Domains (4) summary
      COG5048
      Location:381 → 813
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:693 → 713
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:873 → 898
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      53333749..53356906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439677.1 → XP_047295633.1  zinc finger protein 845 isoform X1

      UniProtKB/Swiss-Prot
      Q96IR2
      Conserved Domains (4) summary
      COG5048
      Location:381 → 813
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:693 → 713
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:873 → 898
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      56413246..56436414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322608.1 → XP_054178583.1  zinc finger protein 845 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96IR2.3 GenPept UniProtKB/Swiss-Prot:Q96IR2

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