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    HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

    Gene ID: 8924, updated on 3-Nov-2024

    Summary

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    Official Symbol
    HERC2provided by HGNC
    Official Full Name
    HECT and RLD domain containing E3 ubiquitin protein ligase 2provided by HGNC
    Primary source
    HGNC:HGNC:4868
    See related
    Ensembl:ENSG00000128731 MIM:605837; AllianceGenome:HGNC:4868
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    jdf2; p528; MRT38; SHEP1; D15F37S1
    Summary
    This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]
    Expression
    Ubiquitous expression in brain (RPKM 8.9), ovary (RPKM 8.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HERC2 in Genome Data Viewer
    Location:
    15q13.1
    Exon count:
    98
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (28111040..28322179, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (25853561..26064943, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (28356186..28567325, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit gamma3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:27585914-27587113 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:27603646-27604146 Neighboring gene serpin family E member 4, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:27657550-27658104 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:27699000-27700199 Neighboring gene Sharpr-MPRA regulatory region 4259 Neighboring gene NANOG hESC enhancer GRCh37_chr15:27757723-27758304 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:27833083-27833211 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:27883709-27884453 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:27890620-27891400 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:27931705-27932684 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:27939287-27940486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:27947009-27947605 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:27958849-27960048 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:27996457-27996958 Neighboring gene OCA2 melanosomal transmembrane protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28115926-28116426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28142467-28142967 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:28149284-28149784 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_39258 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_39278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28228378-28228878 Neighboring gene ribosomal protein L5 pseudogene 32 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28264414-28265082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28268807-28269306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28343756-28344408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:28352349-28352910 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:28352911-28353471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28359141-28359640 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 15:28365618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:28377589-28378366 Neighboring gene MPRA-validated peak2277 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:28526505-28527006 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:28537256-28537799 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:28563777-28564427 Neighboring gene pectinesterase inhibitor 10-like Neighboring gene ribosomal protein L41 pseudogene 2 Neighboring gene HERC2 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression. Eiberg H, et al. Hum Genet, 2008 Mar. PMID 18172690
    2. Novel loss-of-function mutation in HERC2 is associated with severe developmental delay and paediatric lethality. Elpidorou M, et al. J Med Genet, 2021 May. PMID 32571899, Free PMC Article
    3. The ZZ domain of HERC2 is a receptor of arginylated substrates. Tencer AH, et al. Sci Rep, 2022 Apr 11. PMID 35411094, Free PMC Article
    4. Prognostic impact of HERC2 protein and pink-eyed dilution protein in uveal melanoma. Kashyap S, et al. Hum Cell, 2020 Oct. PMID 32686068
    5. Resolving the Insertion Sites of Polymorphic Duplications Reveals a HERC2 Haplotype under Selection. Saitou M, et al. Genome Biol Evol, 2019 Jun 1. PMID 31124564, Free PMC Article

    See all (188) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanism of orphan subunit recognition during assembly quality control.
      Title: Mechanism of orphan subunit recognition during assembly quality control.
    2. EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole.
      Title: EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole.
    3. HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway.
      Title: HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway.
    4. Common genetic variants associated with melanoma risk or naevus count in patients with wildtype MC1R melanoma.
      Title: Common genetic variants associated with melanoma risk or naevus count in patients with wildtype MC1R melanoma.
    5. HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress.
      Title: HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress.
    6. Genetic diagnosis in Sudanese and Tunisian families with syndromic intellectual disability through exome sequencing.
      Title: Genetic diagnosis in Sudanese and Tunisian families with syndromic intellectual disability through exome sequencing.
    7. Delineating the expanding phenotype of HERC2-related disorders: The impact of biallelic loss of function versus missense variation.
      Title: Delineating the expanding phenotype of HERC2-related disorders: The impact of biallelic loss of function versus missense variation.
    8. The ZZ domain of HERC2 is a receptor of arginylated substrates.
      Title: The ZZ domain of HERC2 is a receptor of arginylated substrates.
    9. Further insight into the global variability of the OCA2-HERC2 locus for human pigmentation from multiallelic markers.
      Title: Further insight into the global variability of the OCA2-HERC2 locus for human pigmentation from multiallelic markers.
    10. Blended phenotype of combination of HERC2 and AP3B2 deficiency and Angelman syndrome caused by paternal isodisomy of chromosome 15.
      Title: Blended phenotype of combination of HERC2 and AP3B2 deficiency and Angelman syndrome caused by paternal isodisomy of chromosome 15.
    Submit: New GeneRIF Correction See all GeneRIFs (59)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Developmental delay with autism spectrum disorder and gait instability
    MedGen: C3809753 OMIM: 615516 GeneReviews: Not available
    		not available
    Prader-Willi syndrome
    MedGen: C0032897 OMIM: 176270 GeneReviews: Prader-Willi Syndrome
    		not available
    SKIN/HAIR/EYE PIGMENTATION 1, BLUE/NONBLUE EYES
    MedGen: C1856895 OMIM: 227220 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
    EBI GWAS Catalog
    Digital quantification of human eye color highlights genetic association of three new loci.
    EBI GWAS Catalog
    Genetic determinants of hair, eye and skin pigmentation in Europeans.
    EBI GWAS Catalog
    Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
    EBI GWAS Catalog
    Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
    EBI GWAS Catalog
    Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations.
    EBI GWAS Catalog
    The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
    EBI GWAS Catalog
    Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene.
    EBI GWAS Catalog
    Web-based, participant-driven studies yield novel genetic associations for common traits.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with hect domain and RLD 2 (HERC2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0393, DKFZp547P028

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SUMO binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HERC2
    Names
    HECT-type E3 ubiquitin transferase HERC2
    hect domain and RCC1-like domain-containing protein 2
    hect domain and RLD 2
    probable E3 ubiquitin-protein ligase HERC2
    NP_004658.3
    XP_005268333.1
    XP_006720789.1
    XP_006720790.1
    XP_016878184.1
    XP_016878185.1
    XP_016878186.1
    XP_016878187.1
    XP_047289162.1
    XP_047289163.1
    XP_047289164.1
    XP_047289165.1
    XP_054187823.1
    XP_054187824.1
    XP_054187825.1
    XP_054187826.1
    XP_054187827.1
    XP_054187828.1
    XP_054187829.1
    XP_054187830.1
    XP_054187831.1
    XP_054187832.1
    XP_054187833.1
    XP_054235020.1
    XP_054235021.1
    XP_054235022.1
    XP_054235023.1
    XP_054235024.1
    XP_054235025.1
    XP_054235026.1
    XP_054235027.1
    XP_054235028.1
    XP_054235029.1
    XP_054235030.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016355.1 RefSeqGene

      Range
      4971..216110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004667.6 → NP_004658.3  E3 ubiquitin-protein ligase HERC2

      See identical proteins and their annotated locations for NP_004658.3

      Status: REVIEWED

      Source sequence(s)
      AC091304, AC126332, AC135329, AF071172, AI820017, AK122977, AU100235, AW897649, BC148318, BX440995, CF135750, CX784863, DA868501
      Consensus CDS
      CCDS10021.1
      UniProtKB/Swiss-Prot
      O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1
      Related
      ENSP00000261609.8, ENST00000261609.13
      Conserved Domains (10) summary
      cd08664
      Location:2765 → 2910
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      smart00119
      Location:4464 → 4790
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:4421 → 4792
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2706 → 2750
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:2460 → 2507
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:1209 → 1282
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00415
      Location:675 → 724
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam06701
      Location:1870 → 1929
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:2554 → 2631
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13540
      Location:4039 → 4069
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      28111040..28322179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006720727.4 → XP_006720790.1  E3 ubiquitin-protein ligase HERC2 isoform X4

      See identical proteins and their annotated locations for XP_006720790.1

      Conserved Domains (10) summary
      cd08664
      Location:2679 → 2824
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      smart00119
      Location:4378 → 4704
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:4335 → 4706
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2620 → 2664
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:2374 → 2421
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:1123 → 1196
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00415
      Location:589 → 638
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam06701
      Location:1784 → 1843
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:2468 → 2545
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13540
      Location:3953 → 3983
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    2. XM_006720726.4 → XP_006720789.1  E3 ubiquitin-protein ligase HERC2 isoform X1

      See identical proteins and their annotated locations for XP_006720789.1

      Conserved Domains (10) summary
      cd08664
      Location:2760 → 2905
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      smart00119
      Location:4459 → 4785
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:4416 → 4787
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2701 → 2745
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:2455 → 2502
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:1204 → 1277
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00415
      Location:675 → 724
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam06701
      Location:1865 → 1924
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:2549 → 2626
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13540
      Location:4034 → 4064
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    3. XM_005268276.6 → XP_005268333.1  E3 ubiquitin-protein ligase HERC2 isoform X3

      See identical proteins and their annotated locations for XP_005268333.1

      Conserved Domains (10) summary
      cd08664
      Location:2727 → 2872
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      smart00119
      Location:4426 → 4752
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:4383 → 4754
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2668 → 2712
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:2422 → 2469
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:1171 → 1244
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00415
      Location:637 → 686
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam06701
      Location:1832 → 1891
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:2516 → 2593
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13540
      Location:4001 → 4031
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    4. XM_017022695.1 → XP_016878184.1  E3 ubiquitin-protein ligase HERC2 isoform X3

      Conserved Domains (10) summary
      cd08664
      Location:2727 → 2872
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      smart00119
      Location:4426 → 4752
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:4383 → 4754
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2668 → 2712
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:2422 → 2469
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:1171 → 1244
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00415
      Location:637 → 686
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam06701
      Location:1832 → 1891
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:2516 → 2593
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13540
      Location:4001 → 4031
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    5. XM_047433206.1 → XP_047289162.1  E3 ubiquitin-protein ligase HERC2 isoform X2

    6. XM_017022696.2 → XP_016878185.1  E3 ubiquitin-protein ligase HERC2 isoform X3

      Conserved Domains (10) summary
      cd08664
      Location:2727 → 2872
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      smart00119
      Location:4426 → 4752
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:4383 → 4754
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2668 → 2712
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:2422 → 2469
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins
      pfam00173
      Location:1171 → 1244
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00415
      Location:637 → 686
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam06701
      Location:1832 → 1891
      MIB_HERC2; Mib_herc2
      pfam11515
      Location:2516 → 2593
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13540
      Location:4001 → 4031
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    7. XM_047433207.1 → XP_047289163.1  E3 ubiquitin-protein ligase HERC2 isoform X5

    8. XM_017022697.2 → XP_016878186.1  E3 ubiquitin-protein ligase HERC2 isoform X8

      UniProtKB/TrEMBL
      A0A0J9YVP0

    9. XM_017022698.2 → XP_016878187.1  E3 ubiquitin-protein ligase HERC2 isoform X8

      UniProtKB/TrEMBL
      A0A0J9YVP0

    10. XM_047433208.1 → XP_047289164.1  E3 ubiquitin-protein ligase HERC2 isoform X6

    11. XM_047433209.1 → XP_047289165.1  E3 ubiquitin-protein ligase HERC2 isoform X7

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_011332701.1 Reference GRCh38.p14 PATCHES

      Range
      244504..455617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331853.1 → XP_054187828.1  E3 ubiquitin-protein ligase HERC2 isoform X4

    2. XM_054331848.1 → XP_054187823.1  E3 ubiquitin-protein ligase HERC2 isoform X1

    3. XM_054331852.1 → XP_054187827.1  E3 ubiquitin-protein ligase HERC2 isoform X3

    4. XM_054331850.1 → XP_054187825.1  E3 ubiquitin-protein ligase HERC2 isoform X3

    5. XM_054331849.1 → XP_054187824.1  E3 ubiquitin-protein ligase HERC2 isoform X2

    6. XM_054331851.1 → XP_054187826.1  E3 ubiquitin-protein ligase HERC2 isoform X3

    7. XM_054331854.1 → XP_054187829.1  E3 ubiquitin-protein ligase HERC2 isoform X5

    8. XM_054331857.1 → XP_054187832.1  E3 ubiquitin-protein ligase HERC2 isoform X8

    9. XM_054331858.1 → XP_054187833.1  E3 ubiquitin-protein ligase HERC2 isoform X8

    10. XM_054331855.1 → XP_054187830.1  E3 ubiquitin-protein ligase HERC2 isoform X6

    11. XM_054331856.1 → XP_054187831.1  E3 ubiquitin-protein ligase HERC2 isoform X7

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187660.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      244504..569403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      25853561..26064943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379050.1 → XP_054235025.1  E3 ubiquitin-protein ligase HERC2 isoform X4

    2. XM_054379045.1 → XP_054235020.1  E3 ubiquitin-protein ligase HERC2 isoform X1

    3. XM_054379049.1 → XP_054235024.1  E3 ubiquitin-protein ligase HERC2 isoform X3

    4. XM_054379047.1 → XP_054235022.1  E3 ubiquitin-protein ligase HERC2 isoform X3

    5. XM_054379046.1 → XP_054235021.1  E3 ubiquitin-protein ligase HERC2 isoform X2

    6. XM_054379048.1 → XP_054235023.1  E3 ubiquitin-protein ligase HERC2 isoform X3

    7. XM_054379051.1 → XP_054235026.1  E3 ubiquitin-protein ligase HERC2 isoform X5

    8. XM_054379054.1 → XP_054235029.1  E3 ubiquitin-protein ligase HERC2 isoform X8

    9. XM_054379055.1 → XP_054235030.1  E3 ubiquitin-protein ligase HERC2 isoform X8

    10. XM_054379052.1 → XP_054235027.1  E3 ubiquitin-protein ligase HERC2 isoform X6

    11. XM_054379053.1 → XP_054235028.1  E3 ubiquitin-protein ligase HERC2 isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95714.2 GenPept UniProtKB/Swiss-Prot:O95714

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