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    TCEAL3 transcription elongation factor A like 3 [ Homo sapiens (human) ]

    Gene ID: 85012, updated on 3-Nov-2024

    Summary

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    Official Symbol
    TCEAL3provided by HGNC
    Official Full Name
    transcription elongation factor A like 3provided by HGNC
    Primary source
    HGNC:HGNC:28247
    See related
    Ensembl:ENSG00000196507 AllianceGenome:HGNC:28247
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WEX8
    Summary
    This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 39.3), brain (RPKM 35.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TCEAL3 in Genome Data Viewer
    Location:
    Xq22.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103607963..103609927)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (102054947..102056911)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102862891..102864855)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29820 Neighboring gene long intergenic non-protein coding RNA 2589 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:102809676-102810875 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102840363-102841076 Neighboring gene transcription elongation factor A like 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29821 Neighboring gene Sharpr-MPRA regulatory region 5968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29823 Neighboring gene transcription elongation factor A like 1 Neighboring gene CNEP1R1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR. Pillutla RC, et al. Genomics, 1999 Mar 1. PMID 10051408
    2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. Winter EE, et al. BMC Evol Biol, 2005 Oct 12. PMID 16221301, Free PMC Article
    3. Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability. Silva LE, et al. J Proteome Res, 2019 Oct 4. PMID 31478661
    4. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    5. Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells. Ryu SW, et al. PLoS Biol, 2020 Jul. PMID 32687490, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterizes TCEAL1, another member of the human TCEAL gene family.
      Title: Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: TCEAL1

    Homology

    Clone Names

    • MGC15737

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription elongation factor A protein-like 3
    Names
    TCEA-like protein 3
    transcription elongation factor A (SII)-like 3
    transcription elongation factor S-II protein-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006933.2 → NP_001006934.1  transcription elongation factor A protein-like 3

      See identical proteins and their annotated locations for NP_001006934.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AF163263, BC008703
      Consensus CDS
      CCDS14511.1
      UniProtKB/Swiss-Prot
      D3DXA4, Q969E4
      Related
      ENSP00000243286.3, ENST00000243286.7
      Conserved Domains (2) summary
      pfam04538
      Location:81 → 173
      BEX; Brain expressed X-linked like family
      cl27511
      Location:2 → 104
      Na_Ca_ex; Sodium/calcium exchanger protein

    2. NM_032926.3 → NP_116315.1  transcription elongation factor A protein-like 3

      See identical proteins and their annotated locations for NP_116315.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      BC008703
      Consensus CDS
      CCDS14511.1
      UniProtKB/Swiss-Prot
      D3DXA4, Q969E4
      Related
      ENSP00000361710.5, ENST00000372627.10
      Conserved Domains (2) summary
      pfam04538
      Location:81 → 173
      BEX; Brain expressed X-linked like family
      cl27511
      Location:2 → 104
      Na_Ca_ex; Sodium/calcium exchanger protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      103607963..103609927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      102054947..102056911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q969E4.1 GenPept UniProtKB/Swiss-Prot:Q969E4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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