U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    UBASH3B ubiquitin associated and SH3 domain containing B [ Homo sapiens (human) ]

    Gene ID: 84959, updated on 3-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    UBASH3Bprovided by HGNC
    Official Full Name
    ubiquitin associated and SH3 domain containing Bprovided by HGNC
    Primary source
    HGNC:HGNC:29884
    See related
    Ensembl:ENSG00000154127 MIM:609201; AllianceGenome:HGNC:29884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p70; STS1; STS-1; TULA2; TULA-2
    Summary
    This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 7.0), placenta (RPKM 6.8) and 18 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See UBASH3B in Genome Data Viewer
    Location:
    11q24.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (122655722..122814473)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (122683359..122842181)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (122526430..122685181)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 592, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:122489240-122489740 Neighboring gene Sharpr-MPRA regulatory region 14714 Neighboring gene glutamate-ammonia ligase pseudogene 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:122526335-122526836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4009 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:122541852-122542352 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:122558486-122558986 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:122615185-122616152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5669 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:122625977-122626130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:122673978-122674720 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:122675524-122676042 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:122683300-122683908 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:122683909-122684516 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:122702884-122703556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5674 Neighboring gene cytotoxic and regulatory T cell molecule Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4010 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:122791170-122791781 Neighboring gene junctional cadherin complex regulator Neighboring gene RNA, U4 small nuclear 23, pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Integrative phosphoproteome and interactome analysis of the role of Ubash3b in BCR-ABL signaling. Cutler JA, et al. Leukemia, 2020 Jan. PMID 31399640, Free PMC Article
    2. The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis. Mian AA, et al. Leukemia, 2019 Sep. PMID 30962580, Free PMC Article
    3. TULA-family proteins: Jacks of many trades and then some. Tsygankov AY. J Cell Physiol, 2018 Jan. PMID 30076707
    4. Ubiquitin Associated and SH3 Domain Containing B (UBASH3B) Gene Association with Behcet's Disease in Iranian Population. Shahriyari E, et al. Curr Eye Res, 2019 Feb. PMID 30289285
    5. Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis. Lee ST, et al. Proc Natl Acad Sci U S A, 2013 Jul 2. PMID 23784775, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression.
      Title: FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression.
    2. Ubash3b promotes TPA-mediated suppression of leukemogenesis through accelerated downregulation of PKCdelta protein.
      Title: Ubash3b promotes TPA-mediated suppression of leukemogenesis through accelerated downregulation of PKCδ protein.
    3. An unexpected 2-histidine phosphoesterase activity of suppressor of T-cell receptor signaling protein 1 contributes to the suppression of cell signaling.
      Title: An unexpected 2-histidine phosphoesterase activity of suppressor of T-cell receptor signaling protein 1 contributes to the suppression of cell signaling.
    4. These studies help define a critical role of Ubash3b in leukemia
      Title: Integrative phosphoproteome and interactome analysis of the role of Ubash3b in BCR-ABL signaling.
    5. the UBASH3B gene rs4936742 (T > C) polymorphism is associated with an increased risk of Behcet's disease, especially non-ocular BD, in Iranian population. We could not find any susceptibility role of this genetic locus for posterior uveitis in Behcet's disease.
      Title: Ubiquitin Associated and SH3 Domain Containing B (UBASH3B) Gene Association with Behcet's Disease in Iranian Population.
    6. Sts-1 is a negative regulator.
      Title: The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis.
    7. UBASH3A/STS-2/TULA exhibits substantial homology to UBASH3B/STS-1/TULA-2, but possesses only a small fraction of phosphatase activity of UBASH3B/STS-1/TULA-2, and thus, its regulatory effect may be based also on the phosphatase-independent mechanisms. Critical physiologic effects of these proteins have been demonstrated in T lymphocytes, platelets, stem cells, and other important cell types.
      Title: TULA-family proteins: Jacks of many trades and then some.
    8. Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of ZAP70.
      Title: Insights into the suppressor of T-cell receptor (TCR) signaling-1 (Sts-1)-mediated regulation of TCR signaling through the use of novel substrate-trapping Sts-1 phosphatase variants.
    9. The results show that the interaction between STS-1 and ShcA is regulated in response to EGF receptor activation.
      Title: Identification of STS-1 as a novel ShcA-binding protein.
    10. The study reveals a role of CBL in restricting myeloid proliferation of human AML1-ETOinduced leukemia, and identifies UBASH3B as a potential target for pharmaceutical intervention.
      Title: UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • KIAA1959, MGC15437

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphoprotein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen-activated tyrosine kinase receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of bone resorption IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of platelet aggregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in platelet aggregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of osteoclast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ubiquitin-associated and SH3 domain-containing protein B
    Names
    Cbl-interacting protein Sts-1
    SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate
    T-cell ubiquitin ligand 2
    cbl-interacting protein p70
    nm23-phosphorylated unknown substrate
    suppressor of T-cell receptor signaling 1
    tyrosine-protein phosphatase STS1/TULA2
    NP_001350294.1
    NP_116262.2
    XP_005271769.1
    XP_011541343.1
    XP_054226245.1
    XP_054226246.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363365.2 → NP_001350294.1  ubiquitin-associated and SH3 domain-containing protein B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP002762
      Conserved Domains (2) summary
      cd07067
      Location:351 → 563
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
      cd11936
      Location:221 → 282
      SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B

    2. NM_032873.5 → NP_116262.2  ubiquitin-associated and SH3 domain-containing protein B isoform 1

      See identical proteins and their annotated locations for NP_116262.2

      Status: VALIDATED

      Source sequence(s)
      AK075203, AP002762, BC007541, CR741636
      Consensus CDS
      CCDS31694.1
      UniProtKB/Swiss-Prot
      Q53GT5, Q53GT8, Q8NBV7, Q8TF42, Q96IG9, Q96NZ2
      Related
      ENSP00000284273.5, ENST00000284273.6
      Conserved Domains (3) summary
      cd07067
      Location:386 → 598
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
      cd11936
      Location:256 → 317
      SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
      cd14301
      Location:39 → 76
      UBA_UBS3B; UBA domain found in ubiquitin-associated and SH3 domain-containing protein B (UBS3B) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      122655722..122814473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271712.4 → XP_005271769.1  ubiquitin-associated and SH3 domain-containing protein B isoform X1

      Conserved Domains (3) summary
      cd07067
      Location:414 → 626
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
      cd11936
      Location:284 → 345
      SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
      cl21463
      Location:83 → 104
      UBA_like_SF; UBA domain-like superfamily

    2. XM_011543041.3 → XP_011541343.1  ubiquitin-associated and SH3 domain-containing protein B isoform X2

      Conserved Domains (2) summary
      cd07067
      Location:367 → 579
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
      cd11936
      Location:237 → 298
      SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      122683359..122842181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370270.1 → XP_054226245.1  ubiquitin-associated and SH3 domain-containing protein B isoform X1

    2. XM_054370271.1 → XP_054226246.1  ubiquitin-associated and SH3 domain-containing protein B isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TF42.2 GenPept UniProtKB/Swiss-Prot:Q8TF42

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools