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    kcnj12b potassium inwardly rectifying channel subfamily J member 12b [ Danio rerio (zebrafish) ]

    Gene ID: 795702, updated on 14-Nov-2024

    Summary

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    Official Symbol
    kcnj12bprovided by ZNC
    Official Full Name
    potassium inwardly rectifying channel subfamily J member 12bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-091118-79
    See related
    Ensembl:ENSDARG00000062618 AllianceGenome:ZFIN:ZDB-GENE-091118-79
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-23l10.2
    Summary
    Enables inward rectifier potassium channel activity. Acts upstream of or within potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in brain; head; and heart. Orthologous to human KCNJ12 (potassium inwardly rectifying channel subfamily J member 12). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See kcnj12b in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (16446589..16459293)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (16296816..16308393)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene gap junction protein gamma 1 Neighboring gene elongation factor Tu GTP binding domain containing 2 Neighboring gene myosin-9 Neighboring gene EPS8 signaling adaptor L1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcript expression of inward rectifier potassium channels of Kir2 subfamily in Arctic marine and freshwater fish species. Hassinen M, et al. J Comp Physiol B, 2019 Dec. PMID 31679058
    2. Inward rectifier potassium current (I K1) and Kir2 composition of the zebrafish (Danio rerio) heart. Hassinen M, et al. Pflugers Arch, 2015 Dec. PMID 25991088
    3. Evolution of inwardly rectifying potassium channels and their gene expression in zebrafish embryos. Silic MR, et al. Dev Dyn, 2022 Apr. PMID 34558132, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inward rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-sensitive inward rectifier potassium channel 12
    Names
    Kir2.2b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      16446589..16459293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001335914.9 → XP_001335950.1  ATP-sensitive inward rectifier potassium channel 12

      See identical proteins and their annotated locations for XP_001335950.1

      UniProtKB/TrEMBL
      A0A8M1Q751, E7F807, F6PAH0
      Related
      ENSDARP00000085200.3, ENSDART00000090767.3
      Conserved Domains (2) summary
      pfam01007
      Location:48 → 367
      IRK; Inward rectifier potassium channel
      pfam08466
      Location:2 → 47
      IRK_N; Inward rectifier potassium channel N-terminal

    2. XM_005163848.5 → XP_005163905.1  ATP-sensitive inward rectifier potassium channel 12

      See identical proteins and their annotated locations for XP_005163905.1

      UniProtKB/TrEMBL
      A0A8M1Q751, E7F807, F6PAH0
      Related
      ENSDARP00000116442.1, ENSDART00000141467.2
      Conserved Domains (2) summary
      pfam01007
      Location:48 → 367
      IRK; Inward rectifier potassium channel
      pfam08466
      Location:2 → 47
      IRK_N; Inward rectifier potassium channel N-terminal

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394525.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      85351..92816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471377.2 → XP_021327052.1  ATP-sensitive inward rectifier potassium channel 12

      UniProtKB/TrEMBL
      A0A8M1Q751, E7F807, F6PAH0
      Conserved Domains (2) summary
      pfam01007
      Location:48 → 367
      IRK; Inward rectifier potassium channel
      pfam08466
      Location:2 → 47
      IRK_N; Inward rectifier potassium channel N-terminal
    Nucleotide Protein
    Heading Accession and Version

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