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    ZNF20 zinc finger protein 20 [ Homo sapiens (human) ]

    Gene ID: 7568, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF20provided by HGNC
    Official Full Name
    zinc finger protein 20provided by HGNC
    Primary source
    HGNC:HGNC:12992
    See related
    Ensembl:ENSG00000132010 MIM:194557; AllianceGenome:HGNC:12992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX13
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 5.4), thyroid (RPKM 2.3) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF20 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12131350..12140350, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12259602..12268602, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12242165..12251165, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger family member 788, pseudogene Neighboring gene ribosomal L24 domain containing 1 pseudogene 8 Neighboring gene RNA, 5S ribosomal pseudogene 467 Neighboring gene ZNF625-ZNF20 readthrough (NMD candidate) Neighboring gene ReSE screen-validated silencer GRCh37_chr19:12248934-12249036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10144 Neighboring gene ribosomal protein L17 pseudogene 47 Neighboring gene zinc finger protein 625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10145 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12267212-12267903

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The KOX zinc finger genes: genome wide mapping of 368 ZNF PAC clones with zinc finger gene clusters predominantly in 23 chromosomal loci are confirmed by human sequences annotated in EnsEMBL. Rousseau-Merck MF, et al. Cytogenet Genome Res, 2002. PMID 12697996
    2. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. Rousseau-Merck MF, et al. Hum Genet, 1993 Dec. PMID 8262519
    3. The zinc finger-associated SCAN box is a conserved oligomerization domain. Williams AJ, et al. Mol Cell Biol, 1999 Dec. PMID 10567577, Free PMC Article
    4. Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen HJ. New Biol, 1990 Apr. PMID 2288909
    5. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. Dart AE, et al. J Cell Biol, 2015 Nov 23. PMID 26598620, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ39241

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 20
    Names
    zinc finger protein KOX13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001203250.2 → NP_001190179.1  zinc finger protein 20 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC022415, BM142273, DB034821
      Conserved Domains (6) summary
      smart00349
      Location:4 → 44
      KRAB; krueppel associated box
      COG5048
      Location:112 → 522
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:394 → 414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:406 → 431
      zf-H2C2_2; Zinc-finger double domain

    2. NM_021143.4 → NP_066966.2  zinc finger protein 20 isoform 1

      See identical proteins and their annotated locations for NP_066966.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC022415, BC036714, BM142273, DB057678
      Consensus CDS
      CCDS45986.1
      UniProtKB/Swiss-Prot
      P17024, Q8N457, Q9UG41
      Related
      ENSP00000335437.5, ENST00000334213.10
      Conserved Domains (6) summary
      smart00349
      Location:7 → 47
      KRAB; krueppel associated box
      COG5048
      Location:115 → 525
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:397 → 417
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 46
      KRAB; KRAB box
      pfam13465
      Location:409 → 434
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      12131350..12140350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      12259602..12268602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17024.2 GenPept UniProtKB/Swiss-Prot:P17024

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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