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    Alkal1 ALK and LTK ligand 1 [ Mus musculus (house mouse) ]

    Gene ID: 620393, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Alkal1provided by MGI
    Official Full Name
    ALK and LTK ligand 1provided by MGI
    Primary source
    MGI:MGI:3645495
    See related
    Ensembl:ENSMUSG00000087247 AllianceGenome:MGI:3645495
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Augbeta; Fam150a; EG620393
    Summary
    Predicted to enable protein tyrosine kinase activator activity and signaling receptor binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of MAPK cascade; and positive regulation of neuron projection development. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Orthologous to human ALKAL1 (ALK and LTK ligand 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in stomach adult (RPKM 1.8), lung adult (RPKM 1.1) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Alkal1 in Genome Data Viewer
    Location:
    1 A1; 1 1.89 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (6429555..6464955)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (6359331..6394731)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4732440D04 gene Neighboring gene RB1-inducible coiled-coil 1 Neighboring gene STARR-seq mESC enhancer starr_00078 Neighboring gene STARR-seq mESC enhancer starr_00079 Neighboring gene STARR-seq mESC enhancer starr_00080 Neighboring gene STARR-positive B cell enhancer ABC_E8980 Neighboring gene STARR-seq mESC enhancer starr_00081 Neighboring gene STARR-seq mESC enhancer starr_00082 Neighboring gene uncharacterized protein C9orf40 homolog pseudogene Neighboring gene motile sperm domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00083 Neighboring gene STARR-seq mESC enhancer starr_00085 Neighboring gene STARR-seq mESC enhancer starr_00086 Neighboring gene calmodulin regulated spectrin-associated protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00087 Neighboring gene suppression of tumorigenicity 18 Neighboring gene STARR-seq mESC enhancer starr_00089

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A hypothalamic pathway for Augmentor α-controlled body weight regulation. Ahmed M, et al. Proc Natl Acad Sci U S A, 2022 Apr 19. PMID 35412887, Free PMC Article
    2. MerTK(+) macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activation. Wu N, et al. Sci Adv, 2024 Oct 4. PMID 39365866, Free PMC Article
    3. Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome. Zhang H, et al. Proc Natl Acad Sci U S A, 2014 Nov 4. PMID 25331893, Free PMC Article
    4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MerTK[+] macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activation.
      Title: MerTK(+) macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytokine activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables receptor signaling protein tyrosine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor signaling protein tyrosine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor signaling protein tyrosine kinase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERK5 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERK5 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ERK5 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ALK and LTK ligand 1
    Names
    AUG-beta
    augmentor beta
    family with sequence similarity 150, member A
    protein FAM150A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195732.1 → NP_001182661.1  ALK and LTK ligand 1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      AC139064, AK087278
      Consensus CDS
      CCDS56620.1
      UniProtKB/Swiss-Prot
      J3QPP8
      Related
      ENSMUSP00000137420.2, ENSMUST00000133144.4
      Conserved Domains (1) summary
      pfam15129
      Location:58 → 126
      FAM150; FAM150 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      6429555..6464955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    J3QPP8.1 GenPept UniProtKB/Swiss-Prot:J3QPP8

    Gene LinkOut

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