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    RPL15 ribosomal protein L15 [ Homo sapiens (human) ]

    Gene ID: 6138, updated on 3-Nov-2024

    Summary

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    Official Symbol
    RPL15provided by HGNC
    Official Full Name
    ribosomal protein L15provided by HGNC
    Primary source
    HGNC:HGNC:10306
    See related
    Ensembl:ENSG00000174748 MIM:604174; AllianceGenome:HGNC:10306
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L15; EC45; eL15; DBA12; RPL10; RPLY10; RPYL10
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]
    Expression
    Ubiquitous expression in ovary (RPKM 335.5), thyroid (RPKM 183.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RPL15 in Genome Data Viewer
    Location:
    3p24.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (23916545..23924631)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (23921321..23929407)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (23958036..23966122)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19600 Neighboring gene UBE2E1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14144 Neighboring gene ubiquitin conjugating enzyme E2 E1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19605 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:23906443-23907202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:23924271-23924855 Neighboring gene ARF like GTPase 4A pseudogene 4 Neighboring gene NFKB inhibitor interacting Ras like 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:23958136-23959335 Neighboring gene uncharacterized LOC124909354 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:23987327-23987868 Neighboring gene Sharpr-MPRA regulatory region 12700 Neighboring gene nuclear receptor subfamily 1 group D member 2 Neighboring gene MPRA-validated peak4577 silencer

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Recurring mutations in RPL15 are linked to hydrops fetalis and treatment independence in Diamond-Blackfan anemia. Wlodarski MW, et al. Haematologica, 2018 Jun. PMID 29599205, Free PMC Article
    2. Identification of Differentially Expressed Genes through Integrated Study of Alzheimer's Disease Affected Brain Regions. Puthiyedth N, et al. PLoS One, 2016. PMID 27050411, Free PMC Article
    3. Cloning and characterization of full-length human ribosomal protein L15 cDNA which was overexpressed in esophageal cancer. Wang Q, et al. Gene, 2001 Jan 24. PMID 11223259
    4. Ribosomal Protein L15 is involved in Colon Carcinogenesis. Dong Z, et al. Int J Med Sci, 2019. PMID 31523176, Free PMC Article
    5. Circ-RPL15: a plasma circular RNA as novel oncogenic driver to promote progression of chronic lymphocytic leukemia. Wu Z, et al. Leukemia, 2020 Mar. PMID 31611623

    See all (239) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decreased expression of RPL15 and RPL18 exacerbated the calcification of valve interstitial cells during aortic valve calcification.
      Title: Decreased expression of RPL15 and RPL18 exacerbated the calcification of valve interstitial cells during aortic valve calcification.
    2. Detection of mRNAs of Ribosomal Protein L15 and E-Cadherin in Living Circulating Tumor Cells at Single Cell Resolution To Study Tumor Heterogeneity.
      Title: Detection of mRNAs of Ribosomal Protein L15 and E-Cadherin in Living Circulating Tumor Cells at Single Cell Resolution To Study Tumor Heterogeneity.
    3. Identification of Potential Biomarkers for Intervertebral Disc Degeneration Using the Genome-Wide Expression Analysis.
      Title: Identification of Potential Biomarkers for Intervertebral Disc Degeneration Using the Genome-Wide Expression Analysis.
    4. Overexpressed circ-RPL15 predicts poor survival and promotes the progression of gastric cancer via regulating miR-502-3p/OLFM4/STAT3 pathway.
      Title: Overexpressed circ-RPL15 predicts poor survival and promotes the progression of gastric cancer via regulating miR-502-3p/OLFM4/STAT3 pathway.
    5. Circ-RPL15: a plasma circular RNA as novel oncogenic driver to promote progression of chronic lymphocytic leukemia.
      Title: Circ-RPL15: a plasma circular RNA as novel oncogenic driver to promote progression of chronic lymphocytic leukemia.
    6. RPL15 is required for maintaining normal nucleolar structure. RPL15 is involved in human colon carcinogenesis.RPL15 is overexpressed in colon cancer.
      Title: Ribosomal Protein L15 is involved in Colon Carcinogenesis.
    7. This study identifies a novel subgroup of DBA with mutations in the RPL15 gene with an unexpected high rate of hydrops fetalis and spontaneous, long-lasting remission.
      Title: Recurring mutations in RPL15 are linked to hydrops fetalis and treatment independence in Diamond-Blackfan anemia.
    8. Aurora kinase inhibitor danusertib negatively regulated AURKB/p70S6K/RPL15 axis with the involvement of PI3K/Akt/mTOR, AMPK, and p38 MAPK signaling pathways, leading to the induction of apoptosis and autophagy in human leukemia cells.
      Title: Inhibition of Aurora kinases induces apoptosis and autophagy via AURKB/p70S6K/RPL15 axis in human leukemia cells.
    9. Downregulation of RPL15 is associated with tumor progression in pancreatic ductal adenocarcinoma.
      Title: Downregulation of RPL15 may predict poor survival and associate with tumor progression in pancreatic ductal adenocarcinoma.
    10. These data identify RPL15 as a new gene involved in Diamond-Blackfan anemia.
      Title: Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Diamond-Blackfan anemia 12
    MedGen: C3809888 OMIM: 615550 GeneReviews: Diamond-Blackfan Anemia
    		not available

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2014-07-16)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2014-07-16)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ26304, MGC88603

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in A band IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit HDA PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL15
    Names
    60S ribosomal protein L15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033850.2 RefSeqGene

      Range
      5588..9445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1152

    mRNA and Protein(s)

    1. NM_001253379.2 → NP_001240308.1  large ribosomal subunit protein eL15 isoform 1

      See identical proteins and their annotated locations for NP_001240308.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AC124914, AI886077, BI544251, DA037869
      Consensus CDS
      CCDS2640.1
      UniProtKB/Swiss-Prot
      P39030, P41051, P61313, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
      UniProtKB/TrEMBL
      E7EQV9
      Related
      ENSP00000483260.1, ENST00000611050.4
      Conserved Domains (1) summary
      pfam00827
      Location:2 → 191
      Ribosomal_L15e; Ribosomal L15

    2. NM_001253380.2 → NP_001240309.1  large ribosomal subunit protein eL15 isoform 1

      See identical proteins and their annotated locations for NP_001240309.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AC124914, AI886077, AY347528, DB461802
      Consensus CDS
      CCDS2640.1
      UniProtKB/Swiss-Prot
      P39030, P41051, P61313, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
      UniProtKB/TrEMBL
      E7EQV9
      Related
      ENSP00000346867.5, ENST00000354811.5
      Conserved Domains (1) summary
      pfam00827
      Location:2 → 191
      Ribosomal_L15e; Ribosomal L15

    3. NM_001253382.2 → NP_001240311.1  large ribosomal subunit protein eL15 isoform 1

      See identical proteins and their annotated locations for NP_001240311.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AC124914, AI886077, BE893727, BU178524
      Consensus CDS
      CCDS2640.1
      UniProtKB/Swiss-Prot
      P39030, P41051, P61313, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
      UniProtKB/TrEMBL
      E7EQV9
      Related
      ENSP00000493759.1, ENST00000644185.1
      Conserved Domains (1) summary
      pfam00827
      Location:2 → 191
      Ribosomal_L15e; Ribosomal L15

    4. NM_001253383.3 → NP_001240312.1  large ribosomal subunit protein eL15 isoform 1

      See identical proteins and their annotated locations for NP_001240312.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AC124914, DA205054, DC351786
      Consensus CDS
      CCDS2640.1
      UniProtKB/Swiss-Prot
      P39030, P41051, P61313, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
      UniProtKB/TrEMBL
      E7EQV9
      Related
      ENSP00000416692.1, ENST00000413699.7
      Conserved Domains (1) summary
      pfam00827
      Location:2 → 191
      Ribosomal_L15e; Ribosomal L15

    5. NM_001253384.2 → NP_001240313.1  large ribosomal subunit protein eL15 isoform 2

      See identical proteins and their annotated locations for NP_001240313.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) includes an alternate exon in the 3' UTR and coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC124914, BC081565, BI544251
      Consensus CDS
      CCDS58818.1
      UniProtKB/TrEMBL
      E7EX53
      Related
      ENSP00000398788.2, ENST00000456530.7
      Conserved Domains (1) summary
      cl02977
      Location:2 → 120
      Ribosomal_L15e; Ribosomal L15

    6. NM_002948.5 → NP_002939.2  large ribosomal subunit protein eL15 isoform 1

      See identical proteins and their annotated locations for NP_002939.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AC124914
      Consensus CDS
      CCDS2640.1
      UniProtKB/Swiss-Prot
      P39030, P41051, P61313, Q5U0C0, Q642I1, Q6IPX6, Q8WYP2, Q96C44, Q9H2E5
      UniProtKB/TrEMBL
      E7EQV9
      Related
      ENSP00000309334.5, ENST00000307839.10
      Conserved Domains (1) summary
      pfam00827
      Location:2 → 191
      Ribosomal_L15e; Ribosomal L15

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      23916545..23924631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      23921321..23929407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61313.2 GenPept UniProtKB/Swiss-Prot:P61313

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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