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    SQLE squalene epoxidase [ Canis lupus familiaris (dog) ]

    Gene ID: 608021, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SQLEprovided by VGNC
    Official Full Name
    squalene epoxidaseprovided by VGNC
    Primary source
    VGNC:VGNC:46786
    See related
    Ensembl:ENSCAFG00845012036
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See SQLE in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 13 NC_051817.1 (23335721..23359940)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 13 NC_006595.4 (22958181..22982327)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 13 NC_049234.1 (23408709..23432884)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 13 NC_049273.1 (23056318..23080692)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 13 NC_049754.1 (23165695..23189887)

    Chromosome 13 - NC_051817.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102156610 Neighboring gene zinc finger protein 572 Neighboring gene WASH complex subunit 5 Neighboring gene NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase Neighboring gene uncharacterized LOC111098547

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables squalene monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    squalene monooxygenase
    XP_005627990.1
    XP_005627991.1
    XP_038349159.1
    XP_038349160.1
    XP_038411425.1
    XP_038411426.1
    XP_038475324.1
    XP_038475325.1
    XP_038540932.1
    XP_038540933.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051817.1 Reference ROS_Cfam_1.0

      Range
      23335721..23359940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038685005.1 → XP_038540933.1  squalene monooxygenase

      UniProtKB/TrEMBL
      A0A8C0K1C6, A0A8C0MWQ3, A0A8C0SV77, A0A8I3NFI4
      Related
      ENSCAFP00845016852.1, ENSCAFT00845021443.1
      Conserved Domains (2) summary
      PRK07045
      Location:121 → 426
      PRK07045; putative monooxygenase; Reviewed
      cl21454
      Location:276 → 547
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_038685004.1 → XP_038540932.1  squalene monooxygenase

      UniProtKB/TrEMBL
      A0A8C0K1C6, A0A8C0MWQ3, A0A8C0SV77, A0A8I3NFI4
      Conserved Domains (2) summary
      PRK07045
      Location:121 → 426
      PRK07045; putative monooxygenase; Reviewed
      cl21454
      Location:276 → 547
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049273.1 Alternate UMICH_Zoey_3.1

      Range
      23056318..23080692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038493232.1 → XP_038349160.1  squalene monooxygenase

      Conserved Domains (2) summary
      PRK07045
      Location:121 → 426
      PRK07045; putative monooxygenase; Reviewed
      cl21454
      Location:276 → 547
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_038493231.1 → XP_038349159.1  squalene monooxygenase

      Conserved Domains (2) summary
      PRK07045
      Location:121 → 426
      PRK07045; putative monooxygenase; Reviewed
      cl21454
      Location:276 → 547
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049754.1 Alternate UNSW_CanFamBas_1.0

      Range
      23165695..23189887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038619397.1 → XP_038475325.1  squalene monooxygenase

      Conserved Domains (2) summary
      PRK07045
      Location:121 → 426
      PRK07045; putative monooxygenase; Reviewed
      cl21454
      Location:276 → 547
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_038619396.1 → XP_038475324.1  squalene monooxygenase

      Conserved Domains (2) summary
      PRK07045
      Location:121 → 426
      PRK07045; putative monooxygenase; Reviewed
      cl21454
      Location:276 → 547
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049234.1 Alternate UU_Cfam_GSD_1.0

      Range
      23408709..23432884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038555498.1 → XP_038411426.1  squalene monooxygenase

      UniProtKB/TrEMBL
      A0A8C0K1C6, A0A8C0MWQ3, A0A8C0SV77, A0A8I3NFI4
      Conserved Domains (2) summary
      PRK07045
      Location:121 → 426
      PRK07045; putative monooxygenase; Reviewed
      cl21454
      Location:276 → 547
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_038555497.1 → XP_038411425.1  squalene monooxygenase

      UniProtKB/TrEMBL
      A0A8C0K1C6, A0A8C0MWQ3, A0A8C0SV77, A0A8I3NFI4
      Conserved Domains (2) summary
      PRK07045
      Location:121 → 426
      PRK07045; putative monooxygenase; Reviewed
      cl21454
      Location:276 → 547
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006595.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      22958181..22982327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005627934.4 → XP_005627991.1  squalene monooxygenase

      See identical proteins and their annotated locations for XP_005627991.1

      UniProtKB/TrEMBL
      A0A8C0K1C6, A0A8C0MWQ3, A0A8C0SV77, A0A8I3NFI4
      Conserved Domains (2) summary
      PRK07045
      Location:121 → 426
      PRK07045; putative monooxygenase; Reviewed
      cl21454
      Location:276 → 547
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_005627933.4 → XP_005627990.1  squalene monooxygenase

      See identical proteins and their annotated locations for XP_005627990.1

      UniProtKB/TrEMBL
      A0A8C0K1C6, A0A8C0MWQ3, A0A8C0SV77, A0A8I3NFI4
      Conserved Domains (2) summary
      PRK07045
      Location:121 → 426
      PRK07045; putative monooxygenase; Reviewed
      cl21454
      Location:276 → 547
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version

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