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    Usp29 ubiquitin specific peptidase 29 [ Mus musculus (house mouse) ]

    Gene ID: 57775, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Usp29provided by MGI
    Official Full Name
    ubiquitin specific peptidase 29provided by MGI
    Primary source
    MGI:MGI:1888998
    See related
    Ensembl:ENSMUSG00000051527 AllianceGenome:MGI:1888998
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ocat
    Summary
    Enables cysteine-type endopeptidase activity. Involved in several processes, including positive regulation of type I interferon-mediated signaling pathway; protein K48-linked deubiquitination; and protein stabilization. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; limb bud; testis; and trunk. Orthologous to human USP29 (ubiquitin specific peptidase 29). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 4.9), whole brain E14.5 (RPKM 4.2) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Usp29 in Genome Data Viewer
    Location:
    7 A1; 7 4.04 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6733560..6970219)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6730559..6967220)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger, imprinted 1 Neighboring gene STARR-seq mESC enhancer starr_17985 Neighboring gene Peg3 opposite strand Neighboring gene paternally expressed 3 Neighboring gene Tctex1 domain containing 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17987 Neighboring gene STARR-seq mESC enhancer starr_17989 Neighboring gene microRNA 3099 Neighboring gene STARR-seq mESC enhancer starr_17990 Neighboring gene predicted gene, 53352 Neighboring gene zinc finger, imprinted 3 Neighboring gene STARR-seq mESC enhancer starr_17992 Neighboring gene zinc finger protein 264 Neighboring gene aurora kinase C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress. Wu Y, et al. Cell Death Dis, 2020 Sep 23. PMID 32968046, Free PMC Article
    2. The deubiquitinating gene Usp29 is dispensable for fertility in male mice. Huang Z, et al. Sci China Life Sci, 2019 Apr. PMID 30919279
    3. Transcriptional Truncation of the Long Coding Imprinted Gene Usp29. He H, et al. PLoS One, 2016. PMID 27327533, Free PMC Article
    4. Ocat, a paternally expressed gene closely linked and transcribed in the opposite direction to Peg3. Szeto IY, et al. Genomics, 2000 Jul 15. PMID 10903847
    5. Two evolutionarily conserved sequence elements for Peg3/Usp29 transcription. Kim JD, et al. BMC Mol Biol, 2008 Dec 10. PMID 19068137, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ubiquitin-specific protease 29 attenuates hepatic ischemia-reperfusion injury by mediating TGF-beta-activated kinase 1 deubiquitination.
      Title: Ubiquitin-specific protease 29 attenuates hepatic ischemia-reperfusion injury by mediating TGF-β-activated kinase 1 deubiquitination.
    2. Extracellular vesicles derived from melatonin-preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2.
      Title: Extracellular vesicles derived from melatonin-preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2.
    3. USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity.
      Title: USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity.
    4. USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress.
      Title: USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress.
    5. Ubiquitin-specific processing protease 29 (Usp29) shows predominant expression in mouse testis. Usp29 knockout mice (Usp29(-/-)) have normal fertility and show no detectable difference in the testis/body weight ratio, testicular and epididymal histology as well as epididymal sperm count from the wild-type littermates.
      Title: The deubiquitinating gene Usp29 is dispensable for fertility in male mice.
    6. The mutants with abrogation of the two paternally expressed genes, Peg3 and Usp29, showed a significant decrease in growth rates for both males and females, while the mutants with biallelic expression of Peg3 and Usp29 resulted in an increased growth rate of female mice only
      Title: Allele and dosage specificity of the Peg3 imprinted domain.
    7. the transcription of Usp29 may be involved in DNA methylation setting of Zfp264 promoter in a sex-specific manner.
      Title: Transcriptional Truncation of the Long Coding Imprinted Gene Usp29.
    8. Conserved Sequence Element 2 (YY1 binding sites),functions as an activator for Peg3 transcription, while Conserved Sequence Element 1 acts as a repressor for the transcription of both Peg3 and Usp29.
      Title: Two evolutionarily conserved sequence elements for Peg3/Usp29 transcription.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of type I interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 29
    Names
    ASL1/Usp29 fusion
    deubiquitinating enzyme 29
    ossification center-associated transcript
    ubiquitin thioesterase 29
    ubiquitin thiolesterase 29
    ubiquitin-specific-processing protease 29
    NP_001277923.1
    NP_001347430.1
    NP_001347431.1
    NP_001407092.1
    NP_001407093.1
    NP_067298.2
    XP_011248964.1
    XP_017177905.1
    XP_017177906.1
    XP_030098699.1
    XP_036009191.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290994.1 → NP_001277923.1  ubiquitin carboxyl-terminal hydrolase 29

      See identical proteins and their annotated locations for NP_001277923.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AC149277, AC157657
      Consensus CDS
      CCDS20784.1
      UniProtKB/Swiss-Prot
      C6EQG1, Q9ES63
      Related
      ENSMUSP00000143769.3, ENSMUST00000200535.6
      Conserved Domains (3) summary
      cd13312
      Location:4 → 109
      PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
      pfam00443
      Location:290 → 540
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl02553
      Location:763 → 823
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    2. NM_001360501.2 → NP_001347430.1  ubiquitin carboxyl-terminal hydrolase 29

      Status: VALIDATED

      Source sequence(s)
      AC149277, AC157657
      Consensus CDS
      CCDS20784.1
      UniProtKB/Swiss-Prot
      C6EQG1, Q9ES63
      Conserved Domains (3) summary
      cd13312
      Location:4 → 109
      PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
      pfam00443
      Location:290 → 540
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl02553
      Location:763 → 823
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    3. NM_001360502.2 → NP_001347431.1  ubiquitin carboxyl-terminal hydrolase 29

      Status: VALIDATED

      Source sequence(s)
      AC149277, AC157657
      Consensus CDS
      CCDS20784.1
      UniProtKB/Swiss-Prot
      C6EQG1, Q9ES63
      Conserved Domains (3) summary
      cd13312
      Location:4 → 109
      PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
      pfam00443
      Location:290 → 540
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl02553
      Location:763 → 823
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    4. NM_001420163.1 → NP_001407092.1  ubiquitin carboxyl-terminal hydrolase 29

      Status: VALIDATED

      Source sequence(s)
      AC149277, AC157657
      UniProtKB/Swiss-Prot
      C6EQG1, Q9ES63

    5. NM_001420164.1 → NP_001407093.1  ubiquitin carboxyl-terminal hydrolase 29

      Status: VALIDATED

      Source sequence(s)
      AC149277, AC157657
      UniProtKB/Swiss-Prot
      C6EQG1, Q9ES63

    6. NM_021323.4 → NP_067298.2  ubiquitin carboxyl-terminal hydrolase 29

      See identical proteins and their annotated locations for NP_067298.2

      Status: VALIDATED

      Source sequence(s)
      AC149277, AC157657
      Consensus CDS
      CCDS20784.1
      UniProtKB/Swiss-Prot
      C6EQG1, Q9ES63
      Conserved Domains (3) summary
      cd13312
      Location:4 → 109
      PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
      pfam00443
      Location:290 → 540
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl02553
      Location:763 → 823
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    RNA

    1. NR_153505.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149277, AC157657

    2. NR_153506.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149277, AC157657

    3. NR_153507.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157657
      Related
      ENSMUST00000207899.2

    4. NR_153590.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 3' end compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
      Source sequence(s)
      AC157657, BC063090
      Related
      ENSMUST00000208662.2

    5. NR_185143.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149277, AC157657

    6. NR_185144.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149277, AC157657

    7. NR_185145.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149277, AC157657

    8. NR_185146.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149277, AC157657

    9. NR_185147.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157657

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      6733560..6970219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250662.3 → XP_011248964.1  ubiquitin carboxyl-terminal hydrolase 29 isoform X1

      Conserved Domains (3) summary
      COG5207
      Location:297 → 830
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd13312
      Location:11 → 116
      PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
      pfam00443
      Location:297 → 547
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. XM_030242839.2 → XP_030098699.1  ubiquitin carboxyl-terminal hydrolase 29 isoform X1

      Conserved Domains (3) summary
      COG5207
      Location:297 → 830
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd13312
      Location:11 → 116
      PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
      pfam00443
      Location:297 → 547
      UCH; Ubiquitin carboxyl-terminal hydrolase

    3. XM_017322416.2 → XP_017177905.1  ubiquitin carboxyl-terminal hydrolase 29 isoform X1

      Conserved Domains (3) summary
      COG5207
      Location:297 → 830
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd13312
      Location:11 → 116
      PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
      pfam00443
      Location:297 → 547
      UCH; Ubiquitin carboxyl-terminal hydrolase

    4. XM_017322417.2 → XP_017177906.1  ubiquitin carboxyl-terminal hydrolase 29 isoform X1

      Conserved Domains (3) summary
      COG5207
      Location:297 → 830
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd13312
      Location:11 → 116
      PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
      pfam00443
      Location:297 → 547
      UCH; Ubiquitin carboxyl-terminal hydrolase

    5. XM_036153298.1 → XP_036009191.1  ubiquitin carboxyl-terminal hydrolase 29 isoform X1

      Related
      ENSMUSP00000143267.3, ENSMUST00000198068.3
      Conserved Domains (3) summary
      COG5207
      Location:297 → 830
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd13312
      Location:11 → 116
      PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
      pfam00443
      Location:297 → 547
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ES63.2 GenPept UniProtKB/Swiss-Prot:Q9ES63

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