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    rexo1 REX1, RNA exonuclease 1 homolog [ Danio rerio (zebrafish) ]

    Gene ID: 564551, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rexo1provided by ZNC
    Official Full Name
    REX1, RNA exonuclease 1 homologprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1650
    See related
    Ensembl:ENSDARG00000026986 AllianceGenome:ZFIN:ZDB-GENE-030131-1650
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb77b11; wu:fb77b11; si:dkey-45m5.5
    Summary
    Predicted to enable exonuclease activity. Predicted to be involved in rRNA 3'-end processing. Predicted to be active in nucleus. Orthologous to several human genes including REXO1 (RNA exonuclease 1 homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rexo1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (20455134..20471546)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (20423049..20439461)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene MOB kinase activator 3A Neighboring gene MAPK interacting serine/threonine kinase 2b Neighboring gene diencephalon/mesencephalon homeobox 2 Neighboring gene casein kinase 1, gamma 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Defining the Pluripotent Marker Genes for Identification of Teleost Fish Cell Pluripotency During Reprogramming. Li H, et al. Front Genet, 2022. PMID 35222539, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA exonuclease 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126416.1 → NP_001119888.1  RNA exonuclease 1 homolog

      Status: PROVISIONAL

      Source sequence(s)
      BX511253
      UniProtKB/TrEMBL
      A0A8M1NJD4, B0S6F3
      Related
      ENSDARP00000074070.4, ENSDART00000079618.6
      Conserved Domains (3) summary
      cd06145
      Location:1047 → 1195
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      COG0847
      Location:1060 → 1196
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      pfam15870
      Location:785 → 948
      EloA-BP1; ElonginA binding-protein 1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      20455134..20471546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166869.5 → XP_005166926.1  RNA exonuclease 1 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8M2BEW2
      Conserved Domains (2) summary
      cd06145
      Location:1047 → 1187
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      pfam15870
      Location:785 → 948
      EloA-BP1; ElonginA binding-protein 1
    Nucleotide Protein Strain
    Heading Accession and Version

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