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    kcnn1a potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1a [ Danio rerio (zebrafish) ]

    Gene ID: 563352, updated on 14-Nov-2024

    Summary

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    Official Symbol
    kcnn1aprovided by ZNC
    Official Full Name
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-703
    See related
    Ensembl:ENSDARG00000091306 AllianceGenome:ZFIN:ZDB-GENE-070912-703
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:rp71-39b20.3
    Summary
    Predicted to enable calmodulin binding activity and small conductance calcium-activated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport and potassium ion transport. Predicted to be located in membrane. Predicted to be active in neuron projection; neuronal cell body; and plasma membrane. Is expressed in anterior neural tube; brain; and posterior lateral plate mesoderm. Orthologous to human KCNN1 (potassium calcium-activated channel subfamily N member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See kcnn1a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (24410490..24462288, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (24757067..24816871, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 2, group F, member 6a Neighboring gene zgc:154006 Neighboring gene uncharacterized LOC137487818 Neighboring gene si:rp71-39b20.4 Neighboring gene insulin-like 3 (Leydig cell)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Unraveling the Molecular Players at the Cholinergic Efferent Synapse of the Zebrafish Lateral Line. Carpaneto Freixas AE, et al. J Neurosci, 2021 Jan 6. PMID 33203744, Free PMC Article
    2. Atrium-specific ion channels in the zebrafish-A role of I(KACh) in atrial repolarization. Skarsfeldt MA, et al. Acta Physiol (Oxf), 2018 Jul. PMID 29412518
    3. Electrophysiological Properties of Adult Zebrafish Oligodendrocyte Progenitor Cells. Tsata V, et al. Front Cell Neurosci, 2019. PMID 31031593, Free PMC Article
    4. Phylogenetic and developmental analyses indicate complex functions of calcium-activated potassium channels in zebrafish embryonic development. Silic MR, et al. Dev Dyn, 2021 Oct. PMID 33728688, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small conductance calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small conductance calcium-activated potassium channel protein 1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128248.2 → NP_001121720.2  small conductance calcium-activated potassium channel protein 1a

      Status: VALIDATED

      Source sequence(s)
      BX530024
      UniProtKB/TrEMBL
      A0A8M2BIZ6
      Related
      ENSDARP00000032274.7, ENSDART00000033922.9

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      24410490..24462288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171236.5 → XP_005171293.1  small conductance calcium-activated potassium channel protein 1a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BIK5
      Conserved Domains (4) summary
      cl21524
      Location:758 → 846
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional
      pfam02888
      Location:724 → 799
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:436 → 543
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:631 → 710
      Ion_trans_2; Ion channel

    2. XM_068224537.1 → XP_068080638.1  small conductance calcium-activated potassium channel protein 1a isoform X2

    RNA

    1. XR_011017330.1 RNA Sequence

    2. XR_011017332.1 RNA Sequence

    3. XR_011017331.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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