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    ecm2 extracellular matrix protein 2, female organ and adipocyte specific [ Danio rerio (zebrafish) ]

    Gene ID: 558224, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ecm2provided by ZNC
    Official Full Name
    extracellular matrix protein 2, female organ and adipocyte specificprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050208-651
    See related
    Ensembl:ENSDARG00000071549 AllianceGenome:ZFIN:ZDB-GENE-050208-651
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-42i9.2
    Summary
    Predicted to enable collagen V binding activity and heparin binding activity. Predicted to be involved in extracellular matrix organization and positive regulation of cell-substrate adhesion. Predicted to be active in extracellular matrix. Is expressed in apical ectodermal ridge pectoral fin bud; fin fold pectoral fin bud; median fin fold; pectoral fin; and pharyngeal arch. Orthologous to human ECM2 (extracellular matrix protein 2). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ecm2 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (10490612..10502611, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (10460930..10472975, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene osteomodulin Neighboring gene asporin (LRR class 1) Neighboring gene inositol 1,3,4,5,6-pentakisphosphate 2-kinase Neighboring gene si:dkey-42i9.4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Kolb J, et al. Nat Commun, 2023 Oct 26. PMID 37884489, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables collagen V binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell-substrate adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    extracellular matrix protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      10490612..10502611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_681415.7 → XP_686507.3  extracellular matrix protein 2

      UniProtKB/TrEMBL
      A0A8N7UV16, F1R2S9
      Related
      ENSDARP00000116963.2, ENSDART00000136961.3
      Conserved Domains (5) summary
      cd00116
      Location:437 → 703
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:377 → 400
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00093
      Location:89 → 143
      VWC; von Willebrand factor type C domain
      pfam12799
      Location:375 → 413
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:375 → 437
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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