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    pdk1 pyruvate dehydrogenase kinase, isozyme 1 [ Danio rerio (zebrafish) ]

    Gene ID: 555840, updated on 12-Sep-2024

    Summary

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    Official Symbol
    pdk1provided by ZNC
    Official Full Name
    pyruvate dehydrogenase kinase, isozyme 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-091204-402
    See related
    Ensembl:ENSDARG00000013128 AllianceGenome:ZFIN:ZDB-GENE-091204-402
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:zfos-979f1.3
    Summary
    Predicted to enable pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in protein phosphorylation and regulation of glucose metabolic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in brain. Orthologous to human PDK1 (pyruvate dehydrogenase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 9
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (3129787..3149943, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (3125345..3144028, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:ch211-173m16.2 Neighboring gene protein phosphatase 1 regulatory subunit 9A-like A Neighboring gene finTRIM family, member 52, pseudogene Neighboring gene dynein, cytoplasmic 1, intermediate chain 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. Sips PY, et al. PLoS One, 2018. PMID 29879736, Free PMC Article
    2. Brain Transcriptome Analysis of a Protein-Truncating Mutation in Sortilin-Related Receptor 1 Associated With Early-Onset Familial Alzheimer's Disease Indicates Early Effects on Mitochondrial and Ribosome Function. Barthelson K, et al. J Alzheimers Dis, 2021. PMID 33386808
    3. Accelerated loss of hypoxia response in zebrafish with familial Alzheimer's disease-like mutation of presenilin 1. Newman M, et al. Hum Mol Genet, 2020 Aug 11. PMID 32588886, Free PMC Article
    4. Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish. Cai X, et al. J Biol Chem, 2018 Oct 5. PMID 30126845, Free PMC Article
    5. The tumor suppressor gene lkb1 is essential for glucose homeostasis during zebrafish early development. Kuang X, et al. FEBS Lett, 2016 Jul. PMID 27264935

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial; pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial
    XP_683576.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      3129787..3149943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_678484.7 → XP_683576.2  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial

      UniProtKB/TrEMBL
      A0A8N7UUX2, E7F3U3
      Related
      ENSDARP00000022009.6, ENSDART00000020861.7
      Conserved Domains (3) summary
      smart00387
      Location:239 → 359
      HATPase_c; Histidine kinase-like ATPases
      COG0642
      Location:229 → 358
      BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
      pfam10436
      Location:25 → 189
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
    Nucleotide Protein
    Heading Accession and Version

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