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    cdca7a cell division cycle associated 7a [ Danio rerio (zebrafish) ]

    Gene ID: 550236, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cdca7aprovided by ZNC
    Official Full Name
    cell division cycle associated 7aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-29
    See related
    Ensembl:ENSDARG00000077620 AllianceGenome:ZFIN:ZDB-GENE-050417-29
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cdca7; sb:cb590; sr:nyz142; zgc:110113
    Summary
    Acts upstream of or within regulation of hematopoietic stem cell differentiation and thymus development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; nervous system; neural tube; thymus; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 3. Orthologous to human CDCA7 (cell division cycle associated 7). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cdca7a in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (2879763..2892237, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (2873743..2886233, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911600 Neighboring gene sp3a transcription factor Neighboring gene mitogen-activated protein kinase kinase kinase 20a Neighboring gene Rap guanine nucleotide exchange factor 4a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence. Guiu J, et al. J Exp Med, 2014 Nov 17. PMID 25385755, Free PMC Article
    2. Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish. Ma D, et al. Proc Natl Acad Sci U S A, 2012 Dec 18. PMID 23213226, Free PMC Article
    3. Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome. Rajshekar S, et al. Elife, 2018 Nov 28. PMID 30484769, Free PMC Article
    4. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thymus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle-associated protein 7a
    Names
    cell division cycle associated 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017574.2 → NP_001017574.2  cell division cycle-associated protein 7a

      Status: VALIDATED

      Source sequence(s)
      BX004769
      UniProtKB/TrEMBL
      A0A8M2BES1, B0S4Y9
      Related
      ENSDARP00000117288.1, ENSDART00000140695.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      2879763..2892237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167415.5 → XP_005167472.1  cell division cycle-associated protein 7a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BET8, Q568S8
      Conserved Domains (1) summary
      pfam10497
      Location:300 → 398
      zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1
    Nucleotide Protein Strain
    Heading Accession and Version

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