ING4 inhibitor of growth family member 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ING4provided by HGNC
Official Full Name: inhibitor of growth family member 4provided by HGNC
Primary source: HGNC:HGNC:19423
See related: Ensembl:ENSG00000111653 MIM:608524; AllianceGenome:HGNC:19423
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: my036; p29ING4
Summary: This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in thyroid (RPKM 15.7), endometrium (RPKM 14.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12p13.31

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (6650301..6663119, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (6660668..6673486, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (6759467..6772285, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibitor of Growth 4 (ING4) Plays a Tumor-repressing Role in Oral Squamous Cell Carcinoma via Nuclear Factor Kappa-B (NF-kB)/DNA Methyltransferase 1 (DNMT1) Axis-mediated Regulation of Aldehyde Dehydrogenase 1A2 (ALDH1A2).
Title: Inhibitor of Growth 4 (ING4) Plays a Tumor-repressing Role in Oral Squamous Cell Carcinoma via Nuclear Factor Kappa-B (NF-kB)/DNA Methyltransferase 1 (DNMT1) Axis-mediated Regulation of Aldehyde Dehydrogenase 1A2 (ALDH1A2).
ING4 Expression Landscape and Association With Clinicopathologic Characteristics in Breast Cancer.
Title: ING4 Expression Landscape and Association With Clinicopathologic Characteristics in Breast Cancer.
ING3 and ING4 immunoexpression and their relation to the development of benign odontogenic lesions.
Title: ING3 and ING4 immunoexpression and their relation to the development of benign odontogenic lesions.
[Expression levels of MMP-14, ING4 and HIF-1alpha in 60 patients with oral squamous cell carcinoma and their clinical significance].
Title: [Expression levels of MMP-14, ING4 and HIF-1α in 60 patients with oral squamous cell carcinoma and their clinical significance].
Macromolecular Crowding Increases the Affinity of the PHD of ING4 for the Histone H3K4me3 Mark.
Title: Macromolecular Crowding Increases the Affinity of the PHD of ING4 for the Histone H3K4me3 Mark.
Inhibitor of Growth 4 (ING4) is a positive regulator of rRNA synthesis.
Title: Inhibitor of Growth 4 (ING4) is a positive regulator of rRNA synthesis.
Low ING4 expression is associated with cell proliferation and migration of renal cell carcinoma .
Title: Inhibitor of growth 4 inhibits cell proliferation, migration, and induces apoptosis of renal cell carcinoma cells.
Found antibodies binding to p29ING4.
Title: Autoantibodies against P29ING4 are associated with complex regional pain syndrome.
differential expression profile revealed the potential role of ING4 in prostate cancer pathogenesis possibly through modulation of key genes, pathways and biological networks that are central drivers of the disease.
Title: Identification of the inhibitor of growth protein 4 (ING4) as a potential target in prostate cancer therapy.
These findings suggest that ING4 may inhibit hypoxia-induced EMT via decreasing HIF-1alpha and snail in HK2 cells, indicating the potential of ING4 as a therapeutic target for renal fibrosis.
Title: Inhibitor of growth 4 (ING4) inhibits hypoxia-induced EMT by decreasing HIF-1α and snail in HK2 cells.

Submit: New GeneRIF Correction See all GeneRIFs (82)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ING4_9672 (e-PCR)
- UniSTS:468482

G19629 (e-PCR)
- UniSTS:59160

A001T24 (e-PCR)
- UniSTS:59161

SHGC-83169 (e-PCR)
- UniSTS:95777

D12S2141 (e-PCR)
- UniSTS:50997

RH11183 (e-PCR)
- UniSTS:66445

WI-19753 (e-PCR)
- UniSTS:66995

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
contributes_to histone H3K14 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to histone H4K12 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
NOT contributes_to histone H4K16 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to histone H4K5 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to histone H4K8 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication-dependent chromatin disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein acetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_negative_effect regulation of cell cycle G2/M phase transition	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
part_of histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament cytoskeleton	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inhibitor of growth protein 4

Names: brain my036 protein; candidate tumor suppressor p33 ING1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047151.1 RefSeqGene

Range

5031..17849

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001127582.2 → NP_001121054.1 inhibitor of growth protein 4 isoform 9

See identical proteins and their annotated locations for NP_001121054.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) represents the longest transcript and it encodes the longest protein (isoform 9). Another name for this variant is ING4_v1.

Source sequence(s)

AC135892, AF156552, AW614868, BP303219

Consensus CDS

CCDS44813.1

UniProtKB/Swiss-Prot

A4KYM4, A4KYM6, D3DUR8, Q0EF62, Q0EF63, Q4VBQ6, Q96E15, Q9H3J0, Q9UNL4

Related

ENSP00000380024.4, ENST00000396807.8

Conserved Domains (2) summary

COG5034
Location:7 → 245

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd16862
Location:11 → 104

ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)
NM_001127583.2 → NP_001121055.1 inhibitor of growth protein 4 isoform 3

See identical proteins and their annotated locations for NP_001121055.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses a different splice site in the coding region, compared to variant 9. The resulting protein (isoform 3) is shorter by 3 aa compared to isoform 9. Other names for this variant are ING4_v3 and "9 bp skip variant".

Source sequence(s)

AB197696, AC135892, AF156552, AW614868, BP303219

Consensus CDS

CCDS44814.1

UniProtKB/TrEMBL

B4DDF2

Related

ENSP00000412705.2, ENST00000412586.6

Conserved Domains (2) summary

COG5034
Location:7 → 242

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd16862
Location:11 → 104

ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)
NM_001127584.2 → NP_001121056.1 inhibitor of growth protein 4 isoform 4

See identical proteins and their annotated locations for NP_001121056.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses a different splice site in the coding region, compared to variant 9. The resulting protein (isoform 4) is shorter by 4 aa compared to isoform 9. Other names for this variant are ING4_v4 and "12 bp skip variant".

Source sequence(s)

AB197697, AC135892, AF156552, AW614868, BP303219

Consensus CDS

CCDS44815.1

UniProtKB/Swiss-Prot

Q9UNL4

Related

ENSP00000415903.2, ENST00000446105.6

Conserved Domains (2) summary

COG5034
Location:7 → 241

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd16862
Location:11 → 104

ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)
NM_001127585.2 → NP_001121057.1 inhibitor of growth protein 4 isoform 5

See identical proteins and their annotated locations for NP_001121057.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate segment in the coding region, compared to variant 9. The resulting protein (isoform 5) is shorter when it is compared to isoform 9. Another name for this variant is delta Ex2.

Source sequence(s)

AC135892, AF156552, AW614868, BP303219, EF152349

Consensus CDS

CCDS44812.1

UniProtKB/Swiss-Prot

Q9UNL4

Related

ENSP00000397343.2, ENST00000444704.5

Conserved Domains (2) summary

cd15684
Location:173 → 220

PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)

cl28919
Location:7 → 80

ING; Inhibitor of growth (ING) domain family
NM_001127586.2 → NP_001121058.1 inhibitor of growth protein 4 isoform 6

See identical proteins and their annotated locations for NP_001121058.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an alternate segment in the 3' coding region. which changes the reading frame, compared to variant 9. The resulting protein (isoform 6) is shorter and has a distinct C-terminus when it is compared to isoform 9. Another name for this variant is delta Ex6A.

Source sequence(s)

AC135892, AF156552, AW614868, BP303219, EF152351

Consensus CDS

CCDS44816.1

Related

ENSP00000414008.2, ENST00000423703.6

Conserved Domains (1) summary

pfam12998
Location:6 → 105

ING; Inhibitor of growth proteins N-terminal histone-binding
NM_016162.4 → NP_057246.2 inhibitor of growth protein 4 isoform 1

See identical proteins and their annotated locations for NP_057246.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) uses a different splice site in the coding region, compared to variant 9. The resulting protein (isoform 1) is shorter by 1 aa compared to isoform 9. Other names for this variant are ING4_v2 and "3 bp skip variant".

Source sequence(s)

AC135892, AW614868, BC095434, BP303219

Consensus CDS

CCDS8555.1

UniProtKB/Swiss-Prot

Q9UNL4

Related

ENSP00000343396.4, ENST00000341550.9

Conserved Domains (2) summary

COG5034
Location:7 → 244

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd16862
Location:11 → 104

ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

6650301..6663119 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047428931.1 → XP_047284887.1 inhibitor of growth protein 4 isoform X2
XM_011520964.3 → XP_011519266.1 inhibitor of growth protein 4 isoform X1

Conserved Domains (2) summary

cd15684
Location:172 → 219

PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)

cl28919
Location:7 → 80

ING; Inhibitor of growth (ING) domain family
XM_011520965.4 → XP_011519267.1 inhibitor of growth protein 4 isoform X3

See identical proteins and their annotated locations for XP_011519267.1

Conserved Domains (2) summary

cd15684
Location:170 → 217

PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)

cl28919
Location:1 → 77

ING; Inhibitor of growth (ING) domain family
XM_047428932.1 → XP_047284888.1 inhibitor of growth protein 4 isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

6660668..6673486 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054372181.1 → XP_054228156.1 inhibitor of growth protein 4 isoform X2
XM_054372180.1 → XP_054228155.1 inhibitor of growth protein 4 isoform X1
XM_054372182.1 → XP_054228157.1 inhibitor of growth protein 4 isoform X3
XM_054372183.1 → XP_054228158.1 inhibitor of growth protein 4 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_198287.1: Suppressed sequence

Description

NM_198287.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.