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    HEXA hexosaminidase subunit alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 504468, updated on 4-Oct-2024

    Summary

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    Gene symbol
    HEXA
    Gene description
    hexosaminidase subunit alpha
    See related
    BGD:BT20145; Ensembl:ENSBTAG00000012981
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See HEXA in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (19262091..19296240, complement)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene poly(ADP-ribose) polymerase family member 6 Neighboring gene uncharacterized LOC132346341 Neighboring gene CUGBP Elav-like family member 6 Neighboring gene uncharacterized LOC132346342 Neighboring gene uncharacterized LOC132346340 Neighboring gene transmembrane protein 202

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a 320-kb region containing the HEXA gene on bovine chromosome 10 and analysis of its association with BSE susceptibility. Juling K, et al. Anim Genet, 2008 Aug. PMID 18513278
    2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SNPs in the HEXA region on chromosome 10 have a protective effect against Bovine spongiform encephalopathy.
      Title: Characterization of a 320-kb region containing the HEXA gene on bovine chromosome 10 and analysis of its association with BSE susceptibility.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables beta-N-acetylhexosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ganglioside catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glycosaminoglycan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-hexosaminidase subunit alpha
    Names
    N-acetyl-beta-glucosaminidase subunit alpha
    beta-N-acetylhexosaminidase subunit alpha
    hexosaminidase A (alpha polypeptide)
    hexosaminidase subunit A
    NP_001068632.1
    XP_005211327.1
    XP_024853091.1
    XP_059746239.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075164.2 → NP_001068632.1  beta-hexosaminidase subunit alpha precursor

      See identical proteins and their annotated locations for NP_001068632.1

      Status: PROVISIONAL

      Source sequence(s)
      BT026152
      UniProtKB/Swiss-Prot
      Q0V8R6
      UniProtKB/TrEMBL
      A0AAA9SXA6
      Related
      ENSBTAP00000017261.3, ENSBTAT00000017261.5
      Conserved Domains (2) summary
      cd06562
      Location:167 → 511
      GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...
      pfam14845
      Location:23 → 145
      Glycohydro_20b2; beta-acetyl hexosaminidase like

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      19262091..19296240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005211270.5 → XP_005211327.1  beta-hexosaminidase subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0AAA9SXA6, A0AAA9TTL5
      Related
      ENSBTAP00000100704.1, ENSBTAT00000101913.1
      Conserved Domains (2) summary
      cd06562
      Location:167 → 509
      GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...
      pfam14845
      Location:23 → 145
      Glycohydro_20b2; beta-acetyl hexosaminidase like

    2. XM_024997323.2 → XP_024853091.1  beta-hexosaminidase subunit alpha isoform X2

      Conserved Domains (1) summary
      cd06562
      Location:1 → 319
      GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...

    3. XM_059890256.1 → XP_059746239.1  beta-hexosaminidase subunit alpha isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0V8R6.1 GenPept UniProtKB/Swiss-Prot:Q0V8R6

    Gene LinkOut

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