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    Zdhhc18 zinc finger, DHHC domain containing 18 [ Mus musculus (house mouse) ]

    Gene ID: 503610, updated on 11-Nov-2024

    Summary

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    Official Symbol
    Zdhhc18provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 18provided by MGI
    Primary source
    MGI:MGI:3527792
    See related
    Ensembl:ENSMUSG00000037553 AllianceGenome:MGI:3527792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DHHC-18
    Summary
    Enables palmitoyltransferase activity. Acts upstream of or within protein localization. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC18 (zinc finger DHHC-type palmitoyltransferase 18). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen adult (RPKM 53.1), thymus adult (RPKM 41.2) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zdhhc18 in Genome Data Viewer
    Location:
    4 D2.3; 4 66.25 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133331969..133360801, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133604554..133633490, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11639 Neighboring gene predicted gene, 42324 Neighboring gene stratifin Neighboring gene STARR-positive B cell enhancer ABC_E2717 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133181580-133181767 Neighboring gene predicted gene 13213 Neighboring gene STARR-positive B cell enhancer ABC_E3523 Neighboring gene STARR-seq mESC enhancer starr_11644 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class V Neighboring gene STARR-positive B cell enhancer ABC_E3524

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation. Shi C, et al. EMBO J, 2022 Jun 1. PMID 35438208, Free PMC Article
    2. SAGE2Splice: unmapped SAGE tags reveal novel splice junctions. Kuo BY, et al. PLoS Comput Biol, 2006 Apr. PMID 16683015, Free PMC Article
    3. Identification of PSD-95 palmitoylating enzymes. Fukata M, et al. Neuron, 2004 Dec 16. PMID 15603741
    4. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
    5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation.
      Title: ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cGAS/STING signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cGAS/STING signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC18
    Names
    DHHC domain-containing cysteine-rich protein 18
    zinc finger DHHC domain-containing protein 18
    NP_001017968.2
    XP_006539081.1
    XP_006539083.1
    XP_006539084.1
    XP_006539085.1
    XP_011248601.1
    XP_017175794.1
    XP_036020116.1
    XP_036020117.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017968.2 → NP_001017968.2  palmitoyltransferase ZDHHC18

      See identical proteins and their annotated locations for NP_001017968.2

      Status: VALIDATED

      Source sequence(s)
      AL627228, AY668950, BX537327, CJ049628
      Consensus CDS
      CCDS38906.1
      UniProtKB/Swiss-Prot
      A2A9F0, Q5Y5T2
      Related
      ENSMUSP00000081260.5, ENSMUST00000084238.5
      Conserved Domains (1) summary
      pfam01529
      Location:183 → 306
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      133331969..133360801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320305.3 → XP_017175794.1  palmitoyltransferase ZDHHC18 isoform X3

      Conserved Domains (1) summary
      pfam01529
      Location:183 → 306
      DHHC; DHHC palmitoyltransferase

    2. XM_006539018.2 → XP_006539081.1  palmitoyltransferase ZDHHC18 isoform X1

      Conserved Domains (1) summary
      pfam01529
      Location:183 → 306
      DHHC; DHHC palmitoyltransferase

    3. XM_011250299.3 → XP_011248601.1  palmitoyltransferase ZDHHC18 isoform X5

      See identical proteins and their annotated locations for XP_011248601.1

      Conserved Domains (1) summary
      pfam01529
      Location:183 → 306
      DHHC; DHHC palmitoyltransferase

    4. XM_036164223.1 → XP_036020116.1  palmitoyltransferase ZDHHC18 isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:183 → 268
      DHHC; DHHC palmitoyltransferase

    5. XM_036164224.1 → XP_036020117.1  palmitoyltransferase ZDHHC18 isoform X6

      Conserved Domains (1) summary
      cl19890
      Location:100 → 265
      DHHC; DHHC palmitoyltransferase

    6. XM_006539022.3 → XP_006539085.1  palmitoyltransferase ZDHHC18 isoform X5

      See identical proteins and their annotated locations for XP_006539085.1

      Conserved Domains (1) summary
      pfam01529
      Location:183 → 306
      DHHC; DHHC palmitoyltransferase

    7. XM_006539021.3 → XP_006539084.1  palmitoyltransferase ZDHHC18 isoform X4

      See identical proteins and their annotated locations for XP_006539084.1

      Conserved Domains (1) summary
      pfam01529
      Location:183 → 306
      DHHC; DHHC palmitoyltransferase

    8. XM_006539020.3 → XP_006539083.1  palmitoyltransferase ZDHHC18 isoform X4

      See identical proteins and their annotated locations for XP_006539083.1

      Conserved Domains (1) summary
      pfam01529
      Location:183 → 306
      DHHC; DHHC palmitoyltransferase

    RNA

    1. XR_390767.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5Y5T2.4 GenPept UniProtKB/Swiss-Prot:Q5Y5T2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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