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    mllt10 MLLT10 histone lysine methyltransferase DOT1L cofactor [ Danio rerio (zebrafish) ]

    Gene ID: 492342, updated on 17-Sep-2024

    Summary

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    Official Symbol
    mllt10provided by ZNC
    Official Full Name
    MLLT10 histone lysine methyltransferase DOT1L cofactorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-176
    See related
    Ensembl:ENSDARG00000045401 AllianceGenome:ZFIN:ZDB-GENE-041114-176
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92208; id:ibd5120; wu:fe48f12
    Summary
    Predicted to enable histone binding activity and nucleosome binding activity. Acts upstream of or within canonical Wnt signaling pathway and intestinal epithelial structure maintenance. Predicted to be active in nucleus. Is expressed in brain; hindbrain; intestine; and midbrain. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See mllt10 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (17142784..17216066)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (17000874..17071645)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, alpha a Neighboring gene uncharacterized LOC137489228 Neighboring gene SKI/DACH domain containing 1 Neighboring gene COMM domain containing 3 Neighboring gene bmi1 polycomb ring finger oncogene 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. scaRNAs regulate splicing and vertebrate heart development. Patil P, et al. Biochim Biophys Acta, 2015 Aug. PMID 25916634
    2. The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis. Mahmoudi T, et al. PLoS Biol, 2010 Nov 16. PMID 21103407, Free PMC Article
    3. Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes. England SJ, et al. Front Cell Dev Biol, 2017. PMID 28271061, Free PMC Article
    4. The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Fellous A, et al. Gene, 2019 Mar 1. PMID 30458291
    5. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intestinal epithelial structure maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein AF-10
    Names
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      17142784..17216066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353906.3 → XP_017209395.2  protein AF-10 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YVP0, F8W451
      Conserved Domains (2) summary
      cd15574
      Location:50 → 97
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:148 → 273
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    2. XM_017353907.3 → XP_017209396.2  protein AF-10 isoform X3

      UniProtKB/TrEMBL
      A0A8M6Z452, F8W451
      Conserved Domains (2) summary
      cd15574
      Location:50 → 97
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:148 → 273
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    3. XM_017353909.3 → XP_017209398.2  protein AF-10 isoform X5

      UniProtKB/TrEMBL
      A0A8M6YY56, F8W451
      Conserved Domains (2) summary
      cd15574
      Location:50 → 97
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:148 → 273
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    4. XM_017353908.3 → XP_017209397.2  protein AF-10 isoform X4

      UniProtKB/TrEMBL
      A0A8M6YWA9, F8W451
      Conserved Domains (2) summary
      cd15574
      Location:50 → 97
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:148 → 273
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    5. XM_068217183.1 → XP_068073284.1  protein AF-10 isoform X6

    6. XM_068217182.1 → XP_068073283.1  protein AF-10 isoform X2

    7. XM_017353910.3 → XP_017209399.2  protein AF-10 isoform X7

      UniProtKB/TrEMBL
      A0A8M6Z4S2, F8W451
      Related
      ENSDARP00000156939.1, ENSDART00000192259.1
      Conserved Domains (2) summary
      cd15574
      Location:50 → 97
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:148 → 274
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    8. XM_021470301.2 → XP_021325976.1  protein AF-10 isoform X8

      UniProtKB/TrEMBL
      A0A8M9PUD9, F8W451
      Conserved Domains (2) summary
      cd15574
      Location:50 → 97
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:148 → 273
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    9. XM_017353911.3 → XP_017209400.2  protein AF-10 isoform X11

      UniProtKB/TrEMBL
      A0A8M6YVP4, F8W451
      Conserved Domains (2) summary
      cd15574
      Location:50 → 97
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:148 → 269
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    10. XM_009297359.4 → XP_009295634.2  protein AF-10 isoform X9

      UniProtKB/TrEMBL
      A0A8M3AP65, F8W451
      Related
      ENSDARP00000108632.3, ENSDART00000121821.3
      Conserved Domains (2) summary
      cd15574
      Location:50 → 97
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:104 → 231
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    11. XM_009297362.4 → XP_009295637.2  protein AF-10 isoform X12

      UniProtKB/TrEMBL
      A0A8M3AZ26, F8W451
      Conserved Domains (2) summary
      cd15574
      Location:50 → 97
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:104 → 232
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    12. XM_017353912.3 → XP_017209401.2  protein AF-10 isoform X15

      UniProtKB/TrEMBL
      A0A8M6Z457
      Related
      ENSDARP00000144221.1, ENSDART00000177272.2
      Conserved Domains (2) summary
      cd15574
      Location:50 → 97
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:148 → 273
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    13. XM_068217185.1 → XP_068073286.1  protein AF-10 isoform X10

      Related
      ENSDARP00000123992.1, ENSDART00000149744.2

    14. XM_068217186.1 → XP_068073287.1  protein AF-10 isoform X13

    15. XM_068217187.1 → XP_068073288.1  protein AF-10 isoform X14

      Related
      ENSDARP00000124588.1, ENSDART00000149134.3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001007308.1: Suppressed sequence

      Description
      NM_001007308.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: MLLT10 (GeneID:8028).
    Nucleotide Protein Strain
    Heading Accession and Version

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