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    EGLN2 egl-9 family hypoxia inducible factor 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 484495, updated on 17-Aug-2024

    Summary

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    Official Symbol
    EGLN2provided by VGNC
    Official Full Name
    egl-9 family hypoxia inducible factor 2provided by VGNC
    Primary source
    VGNC:VGNC:97191
    See related
    Ensembl:ENSCAFG00845002985
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See EGLN2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (113591219..113600286, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (112395201..112404270, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (113776727..113785794, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (113150646..113159694, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (112782626..112791680, complement)

    Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 2 subfamily F member 1 Neighboring gene uncharacterized LOC119867810 Neighboring gene uncharacterized LOC119867775 Neighboring gene cytochrome P450 2F2-like Neighboring gene RAB4B, member RAS oncogene family Neighboring gene MIA SH3 domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ferrous iron binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peptidyl-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    egl nine homolog 2; prolyl hydroxylase EGLN2
    XP_005616605.1
    XP_005616606.1
    XP_005616607.1
    XP_038324014.1
    XP_038324015.1
    XP_038324016.1
    XP_038324017.1
    XP_038384755.1
    XP_038384756.1
    XP_038384757.1
    XP_038384758.1
    XP_038449026.1
    XP_038449027.1
    XP_038449028.1
    XP_038449029.1
    XP_038512842.1
    XP_038512843.1
    XP_038512844.1
    XP_038512845.1
    XP_541609.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051805.1 Reference ROS_Cfam_1.0

      Range
      113591219..113600286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038656914.1 → XP_038512842.1  prolyl hydroxylase EGLN2

      UniProtKB/TrEMBL
      A0A8C0S558, A0A8C0S593, A0A8I3MME9, A0A8I3N3U4
      Related
      ENSCAFP00845004195.1, ENSCAFT00845005277.1
      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    2. XM_038656915.1 → XP_038512843.1  prolyl hydroxylase EGLN2

      UniProtKB/TrEMBL
      A0A8C0S558, A0A8C0S593, A0A8I3MME9, A0A8I3N3U4
      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    3. XM_038656916.1 → XP_038512844.1  prolyl hydroxylase EGLN2

      UniProtKB/TrEMBL
      A0A8C0S558, A0A8C0S593, A0A8I3MME9, A0A8I3N3U4
      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    4. XM_038656917.1 → XP_038512845.1  prolyl hydroxylase EGLN2

      UniProtKB/TrEMBL
      A0A8C0S558, A0A8C0S593, A0A8I3MME9, A0A8I3N3U4
      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049261.1 Alternate UMICH_Zoey_3.1

      Range
      113150646..113159694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038468086.1 → XP_038324014.1  prolyl hydroxylase EGLN2

      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    2. XM_038468087.1 → XP_038324015.1  prolyl hydroxylase EGLN2

      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    3. XM_038468088.1 → XP_038324016.1  prolyl hydroxylase EGLN2

      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    4. XM_038468089.1 → XP_038324017.1  prolyl hydroxylase EGLN2

      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

      Range
      112782626..112791680 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038593098.1 → XP_038449026.1  prolyl hydroxylase EGLN2

      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    2. XM_038593099.1 → XP_038449027.1  prolyl hydroxylase EGLN2

      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    3. XM_038593100.1 → XP_038449028.1  prolyl hydroxylase EGLN2

      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    4. XM_038593101.1 → XP_038449029.1  prolyl hydroxylase EGLN2

      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

      Range
      113776727..113785794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038528827.1 → XP_038384755.1  prolyl hydroxylase EGLN2

      UniProtKB/TrEMBL
      A0A8C0S558, A0A8C0S593, A0A8I3MME9, A0A8I3N3U4
      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    2. XM_038528828.1 → XP_038384756.1  prolyl hydroxylase EGLN2

      UniProtKB/TrEMBL
      A0A8C0S558, A0A8C0S593, A0A8I3MME9, A0A8I3N3U4
      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    3. XM_038528829.1 → XP_038384757.1  prolyl hydroxylase EGLN2

      UniProtKB/TrEMBL
      A0A8C0S558, A0A8C0S593, A0A8I3MME9, A0A8I3N3U4
      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    4. XM_038528830.1 → XP_038384758.1  prolyl hydroxylase EGLN2

      UniProtKB/TrEMBL
      A0A8C0S558, A0A8C0S593, A0A8I3MME9, A0A8I3N3U4
      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      112395201..112404270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_541609.7 → XP_541609.1  prolyl hydroxylase EGLN2

      See identical proteins and their annotated locations for XP_541609.1

      UniProtKB/TrEMBL
      A0A8C0S558, A0A8C0S593, A0A8I3MME9, A0A8I3N3U4
      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    2. XM_005616548.4 → XP_005616605.1  prolyl hydroxylase EGLN2

      See identical proteins and their annotated locations for XP_005616605.1

      UniProtKB/TrEMBL
      A0A8C0S558, A0A8C0S593, A0A8I3MME9, A0A8I3N3U4
      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    3. XM_005616549.4 → XP_005616606.1  prolyl hydroxylase EGLN2

      See identical proteins and their annotated locations for XP_005616606.1

      UniProtKB/TrEMBL
      A0A8C0S558, A0A8C0S593, A0A8I3MME9, A0A8I3N3U4
      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    4. XM_005616550.4 → XP_005616607.1  prolyl hydroxylase EGLN2

      See identical proteins and their annotated locations for XP_005616607.1

      UniProtKB/TrEMBL
      A0A8C0S558, A0A8C0S593, A0A8I3MME9, A0A8I3N3U4
      Conserved Domains (1) summary
      smart00702
      Location:197 → 373
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    Nucleotide Protein
    Heading Accession and Version

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