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    SQLE squalene epoxidase [ Pan troglodytes (chimpanzee) ]

    Gene ID: 464383, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SQLEprovided by VGNC
    Official Full Name
    squalene epoxidaseprovided by VGNC
    Primary source
    VGNC:VGNC:789
    Locus tag
    CK820_G0002291
    See related
    Ensembl:ENSPTRG00000020572
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See SQLE in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 7 NC_072405.2 (135328503..135352390)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 8 NC_072406.1 (139922320..139946197)

    Chromosome 7 - NC_072405.2Genomic Context describing neighboring genes Neighboring gene magnesium transporter MRS2 homolog, mitochondrial-like Neighboring gene zinc finger protein 572 Neighboring gene WASH complex subunit 5 Neighboring gene NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables squalene monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    squalene monooxygenase
    XP_009454171.1
    XP_009454172.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072405.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      135328503..135352390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009455896.5 → XP_009454171.1  squalene monooxygenase isoform X1

      See identical proteins and their annotated locations for XP_009454171.1

      UniProtKB/TrEMBL
      A0A2I3T6Q1, A0A2J8PNQ9, A0A6D2VWZ7, H2QWP8
      Related
      ENSPTRP00000035180.3
      Conserved Domains (2) summary
      cl21454
      Location:277 → 548
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl27552
      Location:122 → 427
      FAD_binding_3; FAD binding domain

    2. XM_009455897.5 → XP_009454172.1  squalene monooxygenase isoform X2

      UniProtKB/TrEMBL
      A0A2J8PNQ7
      Related
      ENSPTRP00000084867.1
      Conserved Domains (3) summary
      COG0654
      Location:67 → 441
      UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
      pfam08491
      Location:219 → 490
      SE; Squalene epoxidase
      cl21454
      Location:68 → 117
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version

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