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    EGLN2 egl-9 family hypoxia inducible factor 2 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 456049, updated on 10-Oct-2024

    Summary

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    Official Symbol
    EGLN2provided by VGNC
    Official Full Name
    egl-9 family hypoxia inducible factor 2provided by VGNC
    Primary source
    VGNC:VGNC:14743
    Locus tag
    CK820_G0030486
    See related
    Ensembl:ENSPTRG00000011010
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See EGLN2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 20 NC_072418.2 (43883197..43892230)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 19 NC_072417.1 (43883259..43892253)

    Chromosome 20 - NC_072418.2Genomic Context describing neighboring genes Neighboring gene MIA SH3 domain containing Neighboring gene RAB4B, member RAS oncogene family Neighboring gene uncharacterized LOC738644 Neighboring gene cytochrome P450 2F1-like Neighboring gene cytochrome P450 family 2 subfamily A member 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ferrous iron binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peptidyl-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prolyl hydroxylase EGLN2
    NP_001233442.1
    XP_016789548.3
    XP_016789549.3
    XP_016789550.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001246513.1 → NP_001233442.1  prolyl hydroxylase EGLN2

      See identical proteins and their annotated locations for NP_001233442.1

      Status: PROVISIONAL

      Source sequence(s)
      AK305702
      UniProtKB/TrEMBL
      G2HG38, K7BJY9
      Related
      ENSPTRP00000044177.4, ENSPTRT00000020431.6
      Conserved Domains (1) summary
      smart00702
      Location:199 → 375
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072418.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      43883197..43892230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016934059.4 → XP_016789548.3  prolyl hydroxylase EGLN2 isoform X1

      UniProtKB/TrEMBL
      G2HG38

    2. XM_016934060.4 → XP_016789549.3  prolyl hydroxylase EGLN2 isoform X1

      UniProtKB/TrEMBL
      G2HG38

    3. XM_016934061.4 → XP_016789550.3  prolyl hydroxylase EGLN2 isoform X1

      UniProtKB/TrEMBL
      G2HG38
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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