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    mgat4b alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B [ Danio rerio (zebrafish) ]

    Gene ID: 431727, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mgat4bprovided by ZNC
    Official Full Name
    alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040704-19
    See related
    Ensembl:ENSDARG00000004115 AllianceGenome:ZFIN:ZDB-GENE-040704-19
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92425; wu:fc25g12; mgat4bQ9UQ53
    Summary
    Predicted to enable alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human MGAT4B (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mgat4b in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (16483926..16754249, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (16178273..16448596, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene mastermind-like transcriptional coactivator 1 Neighboring gene calnexin Neighboring gene sequestosome 1 Neighboring gene MRN complex interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Profiling DNA methylation patterns of zebrafish liver associated with parental high dietary arachidonic acid. Adam AC, et al. PLoS One, 2019. PMID 31398226, Free PMC Article
    2. Calnexin is required for zebrafish posterior lateral line development. Hung IC, et al. Int J Dev Biol, 2013. PMID 23873374
    3. Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma. Zheng W, et al. PLoS One, 2014. PMID 24633177, Free PMC Article
    4. High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Varshney GK, et al. Genome Res, 2015 Jul. PMID 26048245, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi stack IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
    Names
    N-acetylglucosaminyltransferase IVb
    N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb
    UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb
    glcNAc-T IVb
    gnT-IVb
    mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
    NP_001002180.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002180.1 → NP_001002180.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

      See identical proteins and their annotated locations for NP_001002180.1

      Status: PROVISIONAL

      Source sequence(s)
      BC074045
      UniProtKB/Swiss-Prot
      Q6GMK0
      Related
      ENSDARP00000000748.9, ENSDART00000001159.11
      Conserved Domains (1) summary
      pfam04666
      Location:109 → 386
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      16483926..16754249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GMK0.1 GenPept UniProtKB/Swiss-Prot:Q6GMK0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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