KLF2 Kruppel like factor 2 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: KLF2provided by CGNC
Official Full Name: Kruppel like factor 2provided by CGNC
Primary source: CGNC:2890
See related: Ensembl:ENSGALG00010027941
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 28

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	28	NC_052559.1 (4830902..4833231, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	28	NC_052600.1 (4393186..4395516, complement)

Chromosome 28 - NC_052559.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Concomitant expression changes in a panel of selected microRNAs regulated by Klf2 suggest importance in lung development. These microRNAs may thus represent potential clinical targets and diagnostic and prognostic tools in thyroid-dependent lung disease.
Title: Hampered Lung Maturation in Methimazole-Induced Hypothyroidism in Fetal Chicken: Morphological and Molecular Correlates to Human Fetal Development.
gKLF2 inhibits chicken adipogenesis, at least in part, through inhibition of PPARgamma and C/EBPalpha expression.
Title: Expression and functional analysis of Krüppel-like factor 2 in chicken adipose tissue.
During chicken adipocyte differentiation, the gene expression of KLF-2 was found to rapidly decrease in the early stage of preadipocyte differentiation.
Title: Characterization of the expression profiles of adipogenesis-related factors, ZNF423, KLFs and FGF10, during preadipocyte differentiation and abdominal adipose tissue development in chickens.
Exposure to low-dose trichloroethylene alters Kruppel-like factor 2 gene expression and function in the developing chick heart.
Title: Exposure to low-dose trichloroethylene alters shear stress gene expression and function in the developing chick heart.
in the embryonic cardiovascular system, KLF-2 is expressed in regions of highest shear stress, and ET-1 and NOS-3 expression is related to shear stress [KLF-2]
Title: Development-related changes in the expression of shear stress responsive genes KLF-2, ET-1, and NOS-3 in the developing cardiovascular system of chicken embryos.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: Krueppel-like factor 2

Names: Kruppel-like factor 2 (lung)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001318423.2 → NP_001305352.1 Krueppel-like factor 2

Status: PROVISIONAL

Source sequence(s)

JAENSK010000376

UniProtKB/TrEMBL

A0A8V1A6C5, E1C442

Related

ENSGALP00010041472.1, ENSGALT00010067729.1

Conserved Domains (4) summary

COG5048
Location:220 → 375

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:299 → 321

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:297 → 321

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:343 → 368

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052559.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

4830902..4833231 complement

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GenBank, FASTA, Sequence Viewer (Graphics)